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Cynthia J. Tsay 《The Yale journal of biology and medicine》2013,86(2):245-254
Julius Wagner-Jauregg, a preeminent Austrian psychiatrist was awarded the Nobel
Prize in Medicine in 1927 for the development of malaria therapy for the
treatment of neurosyphilis, or general paresis of the insane. Despite being only
one of three psychiatrists to win a Nobel Prize, he has faded from public
consciousness and his name recognition pales in comparison to his contemporary
and fellow Austrian, Sigmund Freud. This paper explores his contributions to the
field of biological psychiatry and also touches upon reasons, such as the
growing bioethics movement, his controversial affiliation with the Nazi Party,
and the evolution of neurosyphilis, that explain why Wagner-Jauregg is not more
widely celebrated for his contributions to the field of psychiatry, even though
his malarial treatment could be considered the earliest triumph of biological
psychiatry over psychoanalysis. 相似文献
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观察神经梅毒的临床特点,以提高对神经梅毒的诊断与治疗水平。回顾性分析哈尔滨医科大学附属第一医院2005年1月至2010年12月收治的23例神经梅毒患者的临床资料。神经梅毒患者男17例(73.9%),女6例(26.1%),男女比约为2.8∶1;年龄27~71岁,平均年龄43.1岁。本组首发症状:麻痹性痴呆(7例)、精神异常(3例)、急性脑梗死(3例)、癫痫(2例)、脊髓病变(2例)、颅高压(2例)、周围神经损害(2例)、脑神经损害(1例)、无症状性神经梅毒(1例)。23例患者血清及脑脊液快速血浆反应素实验及梅毒螺旋体血凝试验均呈阳性反应。颅脑电子计算机断层扫描(CT)和/或磁共振成像(MRI)检查多表现为额叶、顶叶、颞叶、基底节等多发病变。本组患者经大剂量青霉素治疗后病情有显著改善20例,死亡1例,自动出院2例。神经梅毒的临床表现复杂多样,神经系统各部位均可受累,诊断依靠病史及临床表现、实验室血清及脑脊液梅毒抗体检测,误诊率高,应早期诊断,诊断后应进行规范治疗,早期治疗效果较好。 相似文献
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