Samarium iodo and terbutylate derivatives coordinated by various chiral ligands have been prepared and used in situ as new catalysts for MPV reductions of aromatic ketones. The most active catalyst is samarium terbutylate binaphtolate albeit with moderate enantioselectivity. 相似文献
The aim of this study was to examine the effect of an infection with Hymenolepis diminuta on ion transport in an isolated colon and blood picture of rats. Fifty rats were orally infected with five cysticercoids of H. diminuta. The experimental groups of rats were assigned to four groups: group I - 8 days post-infection (dpi), group II - 16 dpi, group III - 40 dpi and group IV- 60 dpi. The control group comprised non-infected rats. The experiments consisted of measuring the transepithelial electrical potential difference (PD) and the transepithelial electrical resistance (R) of the rat colon under controlled conditions as well as during mechanical stimulation (MS) using a modified Ussing chamber. Ion transport was modified using inhibitors of the epithelial sodium channel (amiloride - AMI) and the epithelial chloride channel (bumetanide - BUME), and also using capsaicin (CAPSA), a substance which activates C-fibres. The experimental data presented in this study indicates that experimental hymenolepidosis inhibits sodium and chloride ion transport in the epithelium of the rat colon, with preserved tight junction continuity (except at 40 dpi) and a decreased mechanical sensitivity. The effect of capsaicin on ion transport in the rat colon was varied. In control rats it increased ionic current, and in H. diminuta-infected rats it did not cause any changes in PD.Blood picture in this study showed a statistically significantly lower red blood cells (RBC) count and haemoglobin (HGB) concentration in infected rats in comparison to non-infected. Red cell distribution width (RDW) values and platelet (PLT) count were negatively correlated with the duration of infection, whereas mean corpuscular volume (MCV) value was positively correlated. We did not observe leukocytosis during infection, and amongst the differential leukocyte counts eosinophils and basophils showed statistically significant lower values in infected rats in comparison to non-infected.Our results indicate that hymenolepidosis is associated with the activation of inflammatory mediators and stimulation of nervous fibres, which significantly affects the function of ion channels in the epithelium of the colon in the host. At the same time, a significant decrease in eosinophil count during infection suggests that such an infection did not trigger a strong immunological reaction in rats. 相似文献
Thrombotic and inflammatory mechanisms are involved in the pathophysiology of acute coronary syndrome (ACS). The aim of the study was the evaluation of inflammation (white blood cells count/WBC, C-reactive protein/CRP, interleukin-6/IL-6) and platelet (platelet count/PLT, mean platelet volume/MPV, large platelet/LPLT, beta-thromboglobulin/β-TG) biomarkers in the groups of ACS patients depending on the severity of signs and symptoms and compared to controls without coronary artery disease.
Materials and methods
The study group included 93 patients categorized into 3 subgroups depending on the severity of signs and symptoms of ACS. PLT, MPV, LPLT, and WBC were determined on hematological analyzer, IL-6 and β-TG were measured using the ELISA method.
Results
In the whole group of ACS patients WBC, CRP, IL-6, MPV, and β-TG were significantly higher as compared to controls. Analyzing the inflammation and platelet biomarkers depending on the severity of signs and symptoms in comparison to controls, statistically significant differences for above-mentioned parameters were also found. There were no significant differences between the advancement of coronary artery changes and inflammation as well as platelet parameters, except for CRP concentrations. The AUCs for all inflammation parameters tested were similar, however the highest AUCs showed WBC and CRP. Among platelet parameters the highest AUC revealed β-TG.
Conclusion
Markers of inflammation and platelet activation may be associated to myocardial ischemia and myocardial injury. WBC, CRP and IL-6 as inflammation parameters and MPV and β-TG as platelet biomarkers may be useful indicators of the presence of coronary artery disease. 相似文献
Background: Left ventricular assist devices (LVADs) provide support for patients with end-stage heart failure. The aims of this study were to determine whether baseline analysis and early trends in routine laboratory data, platelet activity, and thromboinflammatory biomarkers following LVAD implantation reveal trends that predict personalized risks of one-year gastrointestinal (GI) bleeding, stroke, pump thrombosis, drive-line infections and mortality in patients on LVAD support.
Methods: We performed an observational study at the University of Kentucky with 61 participants who underwent first-time LVAD implantation. Blood was collected at baseline and post-op days 0, 1, 3 and 6 as well as clinical follow-up. Demographics, clinical characteristics, one-year adverse events and routine laboratory data were collected from electronic medical records. Platelet function and plasma biomarkers were profiled.
Results: Evaluation of routine laboratory results revealed that sustained thrombocytopenia and increased mean platelet volume (MPV) were associated with development of GI bleeding and mortality. Platelet function at follow-up visit predicted one-year bleeding events. Thrombotic biomarker sCD40L strongly predicted one-year GI bleeding at baseline before implantation and within the first week following LVAD implant.
Conclusions: Early trends in routine bloodwork and platelet function may serve as novel signatures of patients at risk to experience adverse events. 相似文献
摘要 目的:探索外周血嗜酸性粒细胞比率、血小板平均体积(MPV)、血小板平均宽度(PDW)、大型血小板比率(P-LCT)与重度哮喘患者肺功能及哮喘发作的关系。方法:回顾2017年1月至2018年12月于我院就诊,首次经肺功能检查,诊断为支气管哮喘患者 122例,其中重度患者(SAG) 56例;轻中度患者(n-SAG) 66例。选择同期在我院行健康体检志愿者(CP)的 37名,作为对照组。通过医院HIS系统调取研究对象的年龄、性别,BMI指数等一般资料,调取WBC、EOS%、PLT、PDW、MPV、P-LCT等血液结果,调取FVC pre 、FEV1 pre 、FVC%、FEV1%、FVC post 、FEV1 post 等肺功能检查结果。采用单因素方差分析、Pearson相关分析、Logistic 回归分析等方法对相关指标进行统计分析。结果:正常组的PDW、MPV、P-LCT水平均低于重症哮喘组,具有统计学意义(均P <0.05), 正常组的EOS%水平明显低于重症哮喘组,具有显著统计学意义(P <0.01),重症哮喘患者FVC pre 、FEV1 pre 、FVC%、FEV1%、FVC post 、FEV1 post 均显著低于非重症患者及观察组,具有显著统计学意义(均P <0.01)。Pearson相关性分析显示,EOS%与FEV1改善量具有相关性(r=0.233,P=0.003)。PDW、MPV、P-LCT与FVC改善量均具有显著相关性(均P<0.01), PDW、MPV、P-LCT与FVC变异率、FEV1变异率具有相关性(均P<0.05)。嗜酸性粒细胞与血小板比率(EPR)与FEV1改善量具有相关性(r=0.159,P=0.048)logistic回归分析显示:EOS(Exp(B)=1.203)、P-LCT(Exp(B)=1.086)与哮喘发作密切相关。结论:外周血EOS%、PDW、MPV和P-LCT水平与哮喘肺功能具有密切相关性,在判断哮喘发作风险及哮喘发作严重程度反面具有一定参考作用。 相似文献