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Chunfang Zhang Luping Yu Tao Xu Yichang Hao Xiaowei Zhang Zhenhua Liu Yunbei Xiao Xiaofeng Wang Qiang Zeng 《PloS one》2013,8(3)
Abnormal serum lipid profiles are associated with the risk of some cancers, but the direction and magnitude of the association with renal cell carcinoma is unclear. We explore the relationship between serum lipids and renal cell carcinoma via a matched case-control study. A 1∶2-matched case-control study design was applied, where one renal cell carcinoma patient was matched to two non-renal-cell-carcinoma residents with respect to age (±0 year) and gender. Cases (n = 248) were inpatients with a primary diagnosis of renal cell carcinoma, confirmed by pathology after operations. Controls were sampled from a community survey database matched on age and gender with cases, 2 controls for each case. Stratified Cox proportional hazard regression analysis was used to obtain hazard ratios and corresponding 95% confidence intervals of lipids level and dyslipidemia for the risk of renal cell carcinoma. Elevated serum cholesterol (p<0.001), LDL cholesterol (p<0.001), and HDL cholesterol (p = 0.003) are associated with decreased hazard of renal cell carcinoma, adjusting for obesity, smoke, hypertension and diabetes. However, risk caused by hTG showed no statistical significance (p = 0.263). This study indicates that abnormal lipid profile influences the risk of renal cell carcinoma. 相似文献
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Overexpression of ATP Sulfurylase in Indian Mustard Leads
to Increased Selenate Uptake, Reduction, and Tolerance 总被引:31,自引:3,他引:28 下载免费PDF全文
Elizabeth A.H. Pilon-Smits Seongbin Hwang C. Mel Lytle Yongliang Zhu Jenny C. Tai Rogelio C. Bravo Yichang Chen Tom Leustek Norman Terry 《Plant physiology》1999,119(1):123-132
In earlier studies, the assimilation of selenate by plants appeared to be limited by its reduction, a step that is thought to be mediated by ATP sulfurylase. Here, the Arabidopsis APS1 gene, encoding a plastidic ATP sulfurylase, was constitutively overexpressed in Indian mustard (Brassica juncea). Compared with that in untransformed plants, the ATP sulfurylase activity was 2- to 2.5-fold higher in shoots and roots of transgenic seedlings, and 1.5- to 2-fold higher in shoots but not roots of selenate-supplied mature ATP-sulfurylase-overexpressing (APS) plants. The APS plants showed increased selenate reduction: x-ray absorption spectroscopy showed that root and shoot tissues of mature APS plants contained mostly organic Se (possibly selenomethionine), whereas wild-type plants accumulated selenate. The APS plants were not able to reduce selenate when shoots were removed immediately before selenate was supplied. In addition, Se accumulation in APS plants was 2- to 3-fold higher in shoots and 1.5-fold higher in roots compared with wild-type plants, and Se tolerance was higher in both seedlings and mature APS plants. These studies show that ATP sulfurylase not only mediates selenate reduction in plants, but is also rate limiting for selenate uptake and assimilation. 相似文献
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TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine
Yang Emma Li Yichang Wang Ximing Du Tizhong Zhang Hoi Yin Mak Sarah E. Hancock Holly McEwen Elvis Pandzic Renee M. Whan Yvette Celine Aw Ivan E. Lukmantara Yiqiong Yuan Xiuju Dong Anthony Don Nigel Turner Shiqian Qi Hongyuan Yang 《The Journal of cell biology》2021,220(6)
TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER) and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins. Recently, TMEM41B was identified as a crucial host factor for infection by all coronaviruses and flaviviruses. The molecular function of TMEM41B and VMP1, which belong to a large evolutionarily conserved family, remains elusive. Here, we show that TMEM41B and VMP1 are phospholipid scramblases whose deficiency impairs the normal cellular distribution of cholesterol and phosphatidylserine. Their mechanism of action on LD formation is likely to be different from that of seipin. Their role in maintaining cellular phosphatidylserine and cholesterol homeostasis may partially explain their requirement for viral infection. Our results suggest that the proper sorting and distribution of cellular lipids are essential for organelle biogenesis and viral infection. 相似文献
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重点描述宜昌黄花场剖面中 /下奥陶统界线附近的重要牙形剌共 3属、5种和 2新种Bergstroe mognathussp .nov .,BaltoniodustetrachotomusLiandWangsp .nov .,并对Oepikodusevae带和Baltoniodustriangu laris带分子的首现位置及带的含义进行厘定。作者还在此剖面大湾组下段发现北美中大陆区暖水型牙形剌Tripoduslaevis和Protoprioniodusaranda ,并确定Tripoduslaevis的首现位置在Baltoniodustriangularis带底界之上 0 .3m处。Tripoduslaevis的首次出现曾提议为中奥陶统的底界的标志 (见陈旭等 ,2 0 0 0 ) ,在宜昌黄花场剖面上Tripoduslaevis的首现位置接近Baltoniodustriangularis带底界 ,对确定中 /下奥陶统界线很重要。由于在黄花场剖面可识别出Baltonioduscrassulus—B .gladiatus—B .triangularis演化谱系 ,作者建议以B .triangularis的首次出现作为中奥陶统的底界 ,宜昌黄花场剖面为中 /下奥陶统界线的层型剖面。同时 ,文中将本区的牙形刺带与世界其它地区作了对比。 相似文献
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五峰尖贝原植物形态及有效成分研究 总被引:1,自引:0,他引:1
通过对湖北民间常用中药——五峰尖贝的产地调查,系统地对其原植物及药用器官(鳞茎)的形态及有效成分进行了研究。确定五峰尖贝为百合科(Liliaceae)植物太白贝母(Fritilliaria taipaiensis P.V.Li)。 相似文献
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研究了广西马平灰岩的标准地点柳州楼梯山剖面的地层及其珊瑚,描述皱纹珊瑚7属10种,其中5新种,并系统地阐述了马平组的沿革. 相似文献