排序方式: 共有116条查询结果,搜索用时 218 毫秒
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Raza Zulfiqar Ali Tariq Muhammad Rizwan Majeed Muhammad Irfan Banat Ibrahim M. 《Bioprocess and biosystems engineering》2019,42(6):901-919
Bioprocess and Biosystems Engineering - Polyhydroxyalkanoates (PHAs) are biological plastics that are sustainable alternative to synthetic ones. Numerous microorganisms have been identified as PHAs... 相似文献
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Rizan Chantelle Brophy Tom Lillywhite Robert Reed Malcom Bhutta Mahmood F. 《The International Journal of Life Cycle Assessment》2022,27(6):780-795
The International Journal of Life Cycle Assessment - The primary objective of this study was to evaluate the environmental impact and financial cost of repairing surgical scissors. We used life... 相似文献
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Aisha Sultana Romana Idress Zulfiqar Ali Naqvi Iqbal Azam Shaista Khan Anwar Ali Siddiqui El-Nasir Lalani 《Translational oncology》2014,7(3):355-362
BACKGROUNDImportance of androgen receptor (AR) as an independent prognostic marker in Pakistani women with breast cancer (BCa) remains unexplored. Our aim was to identify the expression and potential prognostic value of AR, its upstream regulator (pAkt) and target gene (pPTEN) in invasive BCa.METHODSThis study used a cohort of 200 Pakistani women with invasive BCa diagnosed during 2002-2011. Expression of AR, pAkt and pPTEN was determined on formalin fixed paraffin embedded tissue sections by immunohistochemistry. The association of AR, pAkt and pPTEN with clinicopathological parameters was determined. Survival analyses were undertaken on patients with ≥ 5 years of follow-up (n = 82).RESULTSExpression of AR, pAkt and pPTEN was observed in 47.5%, 81.3% and 50.6% of patients, respectively. AR-expressing tumors were low or intermediate in grade (P < .001) and expressed ER (P = .002) and PR (P = .001). Patients with AR+ tumors had significantly higher OS (Mean OS = 10.2 ± 0.465 years) compared to patients with AR? tumors (Mean OS = 5.8 ± 0.348 years) (P = .047). Furthermore, AR-positivity was associated with improved OS in patients receiving endocrine therapy (P = .020). Patients with AR+ /pAkt+ /pPTEN? tumors, had increased OS (Mean OS = 7.1 ± 0.535 years) compared to patients with AR?/pAkt+/pPTEN? tumors (Mean OS = 5.1 ± 0.738 years).CONCLUSIONAR-expressing tumors are frequently characterized by low or intermediate grade tumors, expressing ER and PR. In addition, expression of AR, pAkt and pPTEN, could be considered in prognostication of patients with invasive BCa. 相似文献
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Makardhwaj S Shrivastava Zulfiqar Hussain Orsolya Giricz Niraj Shenoy Rahul Polineni Anirban Maitra 《Cell cycle (Georgetown, Tex.)》2014,13(21):3320-3327
Esophageal adenocarcinoma (EAC) is one of the fastest growing malignancies in the US and needs newer therapeutic and diagnostic strategies. Chronic inflammation plays a role in the pathogenesis of EAC and contributes to the dysplastic conversion of normal esophageal epithelium to Barrett's esophagus and frank adenocarcinoma. Chemokines play important roles in mediating inflammation and recent evidence implicates these ligands and their receptors in the development and spread of various tumors. We demonstrated that the chemokines IL8, CXCL1 and CXCL3 are significantly overexpressed during esophageal carcinogenesis and accompanied by amplification and demethylation of the chr4q21 gene locus. We also demonstrated that IL8 levels can be detected in serum of patients with EAC and can serve as potential biomarkers. We now demonstrate that inhibition of IL8 receptor, CXCR2, leads to decreased invasiveness of esophageal adenocarcinoma derived cells without affecting cellular proliferation. Taken together, these studies reveal the important roles that chemokines play in development of esophageal cancer and demonstrate that these pathways can serve as potential therapeutic targets. 相似文献
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Zulfiqar A Malik Dhrubajyoti Chowdhury Deborah K Park Alessandra Renieri James B Ames Johannes W Hell 《The EMBO journal》2014,33(12):1341-1353
Postsynaptic density protein‐95 (PSD‐95) is a central element of the postsynaptic architecture of glutamatergic synapses. PSD‐95 mediates postsynaptic localization of AMPA receptors and NMDA receptors and plays an important role in synaptic plasticity. PSD‐95 is released from postsynaptic membranes in response to Ca2+ influx via NMDA receptors. Here, we show that Ca2+/calmodulin (CaM) binds at the N‐terminus of PSD‐95. Our NMR structure reveals that both lobes of CaM collapse onto a helical structure of PSD‐95 formed at its N‐terminus (residues 1–16). This N‐terminal capping of PSD‐95 by CaM blocks palmitoylation of C3 and C5, which is required for postsynaptic PSD‐95 targeting and the binding of CDKL5, a kinase important for synapse stability. CaM forms extensive hydrophobic contacts with Y12 of PSD‐95. The PSD‐95 mutant Y12E strongly impairs binding to CaM and Ca2+‐induced release of PSD‐95 from the postsynaptic membrane in dendritic spines. Our data indicate that CaM binding to PSD‐95 serves to block palmitoylation of PSD‐95, which in turn promotes Ca2+‐induced dissociation of PSD‐95 from the postsynaptic membrane. 相似文献
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Parthenium poses serious threat to modern crop production system and
necessitate evaluating control practices for its effective management. Efficacy of
different weed control practices for controlling parthenium was explored in conventional and deep tillage systems in the field conditions. Hand hoeing (20 and
35 days after emergence), S-Metolachlor (pre-emergence herbicide), sorghum
straw mulch @ 5 tons ha-1 and combination of hand hoeing and sorghum straw
mulch (hand hoeing at 20 and straw mulch at 35 days after emergence) were used
as weed control practice. Weedy check where no weed control measure was
applied was also included in this experiment for comparison. Results concluded
that the all weed management treatments significantly reduced parthenium density, its fresh and dry biomass during both the years of study as compared to weedy check. Maximum sunflower achene yield was recorded in hand hoeing (20 and
35 days after emergence) in combination with deep tillage. So, mold bold plough
used for the purpose of deep tillage should be encouraged for better control of
parthenium and higher achene yield of sunflower crop (3293.3 kg ha-1 in 2017
and 3221.3 kg ha-1 in 2018). Moreover, is also inferred that total dose of herbicide
might be reduced by using hoeing and mulching in an integrated way. 相似文献