排序方式: 共有10条查询结果,搜索用时 15 毫秒
1
1.
Shchelkanov MY Soinov LA Yudin AN Denisov MV Slavsky AA Petrenko MS Vedenov AA 《Journal of biomolecular structure & dynamics》1999,17(3):597-605
Stochastic properties of previously introduced one parameter discrete model of genetic diversity (M. Yu. Shchelkanov et al, J. Biomol. Struct. Dyn. 15, 887-894 (1998)) are investigated. Two approaches are compared: (A) when the on-step substitution number and/or the number of substitution steps are random variables; (B) referred parameters are replaced by mathematical expectations of the respective variables. It has been demonstrated, that estimations of sequence measure based on the number of replication steps are more under the assumption of case (A) as compared with (B). Thus, real biological situation relating to the case (A) could additionally promote the increasing of distinctions between different taxons (e.g. HIV, etc.). Peculiarities of one-parameter discrete model of genetic diversity during calculation of the distinctions between symbol (e.g. nucleotide) sequence sets are also discussed. 相似文献
2.
Shchelkanov MY Soinov LA Petrenko MS Starikov NS Zalunin VV Slavsky AA Denisov MV Kireev VB Surovoy AY 《Journal of biomolecular structure & dynamics》2000,18(1):103-112
Previously, when discussing the properties of one parameter discrete model of genetic diversity (M.Yu. Shchelkanov et al, J. Biomol. Struct. Dyn. 15, 887-894 (1998)), we took into account Hamming distance distribution only between precursor and arbitrary descendant sequences. However, really there are sets of sequence populations produced during amplification process. In the presented work we have investigated Hamming distance distributions between sequences from different descendant sets produced in the frame of one parameter discrete model. Two basic descendant generation operators (so called amplifiers) are introduced: 1) the last generation amplifier, L, which produces descendants with precursor elimination; 2) all generations amplifier, G, which produces descendants without precursor elimination. Generalization of one-parameter discrete model for the case when precursor sequences do not coincide are carried out. Using this generalization we investigate the distribution of Hamming distances between L- and G-generated sequences. Basic properties of L and G operators, L/G-choice alternative problem have been discussed. Obtained results have common theoretical significance, but they are more suitable for high level genetic diversity process (for example, HIV diversity). 相似文献
3.
Marina Gulyaeva Ivan Sobolev Kirill Sharshov Olga Kurskaya Alexander Alekseev Lidia Shestopalova Anna Kovner Yuhai Bi Weifeng Shi Michael Shchelkanov Alexander Shestopalov 《中国病毒学》2018,33(5):449-452
正Dear Editor Marine mammals are widely distributed and can be found almost in all coastal waters and coastlines around the world. The interface areas between marine and terrestrial environments provide natural habitats for aquatic and semiaquatic mammals as well as for reservoir species of avian influenza viruses (AIV)(Runstadler et al. 2013). Previous 相似文献
4.
Fediakina IT Shchelkanov MIu Deriabin PG Leneva IA Gudova NV Kondrat'eva TV L'vov DK 《Antibiotiki i khimioterapii͡a》2011,56(3-4):3-9
The data on cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pandemic 2009 (H1N1) influenza A viruses are presented. The study of the antiviral activity of antivirals in the MDCK cells culture demonstrated that Arbidol, Rimantadine and Ribavirin efficiently inhibited reproduction of the highly pathogenic H5N1 influenza viruses isolated from sick birds. Arbidol and Oseltamivir carboxylate selectively inhibited reproduction of the pandemic 2009 H1N1 influenza A viruses with changed specificity to the cell receptors, causing severe influenza in men, while remantadine had no effect on their reproduction. 相似文献
5.
Usachev EV Fediakina IT Shchelkanov MIu L'vov DN Prilipov AG Iamnikova SS 《Molekuliarnaia genetika, mikrobiologiia i virusologiia》2006,(1):14-20
The genome of the NDV strain Sterna/Astrakhan/2755/2001 isolated from a wild bird of the Volga River delta in 2001 was completely sequenced. The phylogenetic analysis of the strain investigated and other NDV strains clearly demonstrated that Sterna/Astrakhan/2755/ 2001 belonged to the lineage 5b. Comparative analysis of molecular genetic markers of pathogenicity of strain Sterna/Astrakhan/2755/ 2001 allows its velogenic character to be suggested. 相似文献
6.
Karamov EV Shchelkanov MIu Iudin AN Gorbacheva AP Burunova VV Slavskiĭ AA Lukashov VV Iaroslavtseva NG 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1999,(1):39-41
Different strains of HIV-1, circulating among drug addicts introducing drugs intravenously and detected on the territories of Russia, Ukraine and Belarus, have been characterized by the methods of the comparative analysis of genetic sequences of different variants of HIV (gene typing) and the study of the immunological properties of autoimmune sera (serotyping). 相似文献
7.
Michael Yu. Shchelkanov Lev A. Soinov Vadim V. Zalunin Nicole S. Starikov Andrei A. Natan Victor B. Kireev 《Journal of biomolecular structure & dynamics》2013,31(1):133-138
Abstract With the help of previously introduced enumeration procedure (M.Yu. Shchelkanov, A.N. Yudin, A.V Antonov, N.S. Starikov, A.A. Vedenov, E.V. Karamov, J. Biomol. Struct. Dyn. 15, 217–229 (1997)) and probability distribution function for the enumeration after some substitution steps (M.Yu. Shchelkanov, L.A. Soinov, V.V. Zalunin, D.A. Gumennyi, A.N. Yudin, A.A. Natan, V.B. Kireev, E.V. Karamov, J. Biomol. Struct. Dyn. 15, N 4, (1998)) we have demonstrated that dependencies of replication acts number on Hamming distance are identical for one-parameter discrete models of both direct and parallel genetic diversity. 相似文献
8.
Shchelkanov MY Eremin VF Sakhuriya IB Burunova VV Pavlova TV Kornilaeva GV Karamov EV 《Biochemistry. Biokhimii?a》1999,64(4):431-436
Changes in dehydrogenase activity of some continuous cell lines were studied during the response to acute infection in vitro with HIV-1 variants having different biological features. Soon after infection, the dehydrogenase activity of infected cells increased, and this increase was greater and more prolonged with the HIV-1 r/h variant than with the HIV-1 s/l variant. Later stages showed decreased dehydrogenase activity of HIV-1-infected cells compared to the noninfected control; this is a manifestation of the cytodestructive effect of the virus. The changes increased monotonously (but not in direct proportion) with an increase in the infecting dose. 相似文献
9.
Michael Yu. Shchelkanov Alex N. Yudin Alex V. Antonov Nicole S. Starikov Alexander A. Vedenov Edward V. Karamov 《Journal of biomolecular structure & dynamics》2013,31(2):217-229
Abstract Enumerating procedure for symbol sequences is proposed. Relationship between Hamming distance for symbol sequences and Euclidean distance for corresponding enumerations is established, and more universal Hamming-transformed Euclidean measure is constructed. A distribution function of amino acid substitutions and some of its point estimators (consensus, subconsensus, sample mean, sample central moments and asymmetry coefficient) are introduced. Hamming-transformed Euclidean measures between consensuses, subconsensuses and sample means for ten HIV-1 taxons of gp120 V3 regions are calculated. It is demonstrated that these taxons have a complicated pattern which is significant for their classification. 相似文献
10.
Shestopalov AM Zolotykh SI Shchelkanov MIu Rasumova IuV Alekseev AIu Durymanov AG Iurlov AK Davazhav A Altantsetseg T Tsĕrĕnnorov D Otgonbaatar D Netesov SV Drozdov IG 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2006,(5):55-59
The results of virology inspection of the wild birds living in territory of the Western Mongolia, carried out in 2003-2004 are presented. For the specified period influenza viruses H3 and H4 subtype hemagglutinins are isolated from birds. It is revealed taxonomic and ecological heterogeneity of the birds involved in maintenance of circulation of influenza viruses in the given territory. Influenza viruses are isolated from birds of 5 special groups; among them there are preferring water and nearwater biotops, a species preferring dry plain region, and also a species which habitat does not depend from water's territories. 相似文献
1