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Rivera-Molina Félix E. González-Crespo Sahily Cruz Yasdet Maldonado-De la Ortiz-Betancourt José M. Rodríguez-Medina José R. 《World journal of microbiology & biotechnology》2006,22(3):255-260
Summary Nikkomycin Z (NZ) is a competitive inhibitor of chitin synthase III in the yeast Saccharomyces cerevisiae. Myosin type II-deficient yeast strains (myo1) display a dramatic reduction in growth when chitin synthase III activity is inhibited by NZ, supporting the contention that
actomyosin motility plays an important role in maintaining cell wall integrity. A proposed inhibitor of cortical actin polymerization
in vitro, 2,3-butanedione monoxime (BDM), also inhibits growth of wild-type yeast strains at a concentration of 20 mM. In this study,
we assayed for potential in vivo interplay between BDM-sensitive cell functions and cell wall chitin synthesis by testing for increased sensitivity to NZ
during co-treatment with BDM at sub-inhibitory concentrations. Our results show that BDM can increase the sensitivity of yeast
cells to Nikkomycin Z. 相似文献
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