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Hamdi Ilhem Benmansour Bouchra Zouari-Tlig Sabiha Kamanli Seyit Ali Özak Argun Akif Boxshall Geoffrey Allan 《Systematic parasitology》2021,98(1):57-71
Systematic Parasitology - A new species of parasitic copepod, Caligus tunisiensis n. sp. (Caligidae), is described based on two female specimens collected from the gills of the painted comber,... 相似文献
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Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis 总被引:5,自引:0,他引:5
In recent years, a great number of studies have investigated the possible role of reactive oxygen species in the aetiology and pathogenesis of rheumatoid arthritis (RA). The aim of this study was to investigate plasma concentrations of vitamin E, beta-carotene, activities of glutathione peroxidase (GSH-Px) and catalase, levels of lipid peroxidation (MDA) and reduced glutathione (GSH) in 36 patients with rheumatoid arthritis (RA) and 22 healthy age-matched controls. The plasma activity of GSH-Px and catalase (p < 0.001), levels of GSH (p < 0.01), concentration of beta-carotene (p < 0.05) and vitamin E (p < 0.001), haemoglobin and hematocrit (p < 0.05) were significantly lower in patients with RA than in controls. The MDA levels (p < 0.01), C reactive protein, rheumatoid factor, anti-streptolysin-o values (p < 0.001), platelet count (p < 0.05) and erythrocyte sedimentation rate (p < 0.001) were higher in the patient group than in the control group. These results provide some evidence for a potential role of increased lipid peroxidation and decreased enzymic and non-enzymic antioxidants in RA by its inflammatory character. These results suggested that oxidant stress plays a very important role in the pathogenesis of RA. 相似文献
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Safiye Tuncer Ayhan Kamanli Ethem AkÇil Güzin özelÇi Kavas Bülent SeÇkin Mesut Birol Atay 《Biological trace element research》1999,68(2):137-142
It has been suggested that reactive oxygen metabolites and trace elements play some role in the etiology and pathogenesis
of rheumatoid arthritis (RA). Superoxide dismutase (SOD) is believed to exert an important protective role against oxygen
toxicity. The aim of the study was to investigate the probable changes in the levels of trace elements and SOD activity in
RA. Plasma and erythrocyte copper, zinc, and magnesium levels and erythrocyte SOD activity were measured in groups of controls
and RA cases. Significantly increased erythrocyte SOD activity was found in RA patients in comparison with controls(p < 0.0001). A rise in erythrocyte Zn level(p < 0.0001) and plasma Cu level(p < 0.0001) and a decrease in erythrocyte Cu level(p < 0.05) and plasma Zn level(p < 0.05) were obtained in RA patients when compared to controls. Plasma and erythrocyte Mg levels of the RA patients showed
slight and statistically insignificant reductions when compared to controls(p > 0.05). In RA patients, there were positive correlations between erythrocyte SOD activity and Mg level (r = 0.4345,p < 0.01) and between erythrocyte Zn level and plasma Cu level(r = 0.4132,p < 0.01). There were negative correlations between erythrocyte SOD activity and plasma Zn level(r =-0.3605,p < 0.05) and between plasma Zn level and erythrocyte Cu level(r =-0.4578,p < 0.01) in RA patients.
This work was presented at the International Congress on Free Radicals in Health and Disease, 6–10 September 1995, Istanbul,
Turkey. 相似文献
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