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排序方式: 共有163条查询结果,搜索用时 15 毫秒
1.
Ruxandra Ion L. Telvi Jean-Louis Chaussain Jacques Patrick Barbet Manoel Nunes Anne Safar Marie-Odile Réthoré Marc Fellous Ken McElreavey 《Human genetics》1998,102(2):151-156
In 46,XY individuals, testes are determined by the activity of the SRY gene (sex-determining region Y), located on the short arm of the Ychromosome. The other genetic components of the cascade
that leads to testis formation are unknown and may be located on the Xchromosome or on the autosomes. Evidence for the existence
of several loci associated with failure of male sexual development is indicated by reports of 46,XY gonadal dysgenesis associated
with structural abnormalities of the Xchromosome or of autosomes (chromosomes9, 10, 11 and 17). In this report, we describe
the investigation of a child presenting with multiple congenital abnormalities, mental retardation and partial testicular
failure. The patient had a homogeneous de novo 46,XY,inv dup(9)(pter→p24.1::p21.1 →p23.3::p24.1→qter) chromosome complement.
No deletion was found by either cytogenetic or molecular analysis. The SRY gene and DSS region showed no abnormalities. Southern blotting dosage analysis with 9p probes and fluorescent in situ hybridisation data
indicated that the distal breakpoint of the duplicated fragment was located at 9p24.1, proximal to the SNF2 gene. We therefore suggest that a gene involved in normal testicular development and/or maintenance is present at this position
on chromosome 9.
Received: 20 January 1997 / Accepted: 5 November 1997 相似文献
2.
Ion C. Baianu 《Bulletin of mathematical biology》1980,42(3):431-446
The mathematical structures underlying the theories of organismic sets, (M, R)-systems and molecular sets are shown to be transformed naturally within the theory of categories and functors. Their natural
transformations allow the comparison of distinct entities, as well as the modelling of dynamics in “organismic” structures. 相似文献
3.
Transformations of dynamical systems are discussed in terms of adjoint, simple adjoint and weak adjoint functors. The relevance
of this approach to interpretations of nuclear transplant experiments is suggested, and three new theorems concerning the
development of biological systems are presented. Another three theorems concerning adjoint dynamical systems are proved. The
connection of these results with the theory of organismic sets developed by Rashevsky (1966, 1967a-c, 1968a-c, 1969a-c, 1971a,
b) is also investigated. 相似文献
4.
George Nicolae Daniel Ion George Mihai Nitulescu Costin Ioan Popescu 《Bioorganic & medicinal chemistry letters》2019,29(18):2527-2534
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), also known as Apo2L, has been investigated in the past decade for its promising anticancer activity due to its ability to selectively induce apoptosis in tumoral cells by binding to TRAIL receptors (TRAIL-R). Macromolecules such as agonistic monoclonal antibodies and recombinant TRAIL have not proven efficacious in clinical studies, therefore several small molecules acting as TRAIL-R agonists are emerging in the scientific literature. In this work we focus on systemizing these drug molecules described in the past years, in order to better understand and predict the requirements for a novel anti-tumoral therapy based on the TRAIL-R-induced apoptotic mechanism. 相似文献
5.
Lithium Polyacrylate (LiPAA) as an Advanced Binder and a Passivating Agent for High‐Voltage Li‐Ion Batteries 下载免费PDF全文
Nicholas P. W. Pieczonka Valentina Borgel Baruch Ziv Nicole Leifer Vadim Dargel Doron Aurbach Jung‐Hyun Kim Zhongyi Liu Xiaosong Huang Sergey A. Krachkovskiy Gillian R. Goward Ion Halalay Bob R. Powell Arumugam Manthiram 《Liver Transplantation》2015,5(23)
Intensive studies of an advanced energy material are reported and lithium polyacrylate (LiPAA) is proven to be a surprisingly unique, multifunctional binder for high‐voltage Li‐ion batteries. The absence of effective passivation at the interface of high‐voltage cathodes in Li‐ion batteries may negatively affect their electrochemical performance, due to detrimental phenomena such as electrolyte solution oxidation and dissolution of transition metal cations. A strategy is introduced to build a stable cathode–electrolyte solution interphase for LiNi0.5Mn1.5O4 (LNMO) spinel high‐voltage cathodes during the electrode fabrication process by simply using LiPAA as the cathode binder. LiPAA is a superb binder due to unique adhesion, cohesion, and wetting properties. It forms a uniform thin passivating film on LNMO and conducting carbon particles in composite cathodes and also compensates Li‐ion loss in full Li‐ion batteries by acting as an extra Li source. It is shown that these positive roles of LiPAA lead to a significant improvement in the electrochemical performance (e.g., cycle life, cell impedance, and rate capability) of LNMO/graphite battery prototypes, compared with that obtained using traditional polyvinylidene fluoride (PVdF) binder for LNMO cathodes. In addition, replacing PVdF with LiPAA binder for LNMO cathodes offers better adhesion, lower cost, and clear environmental advantages. 相似文献
6.
Barreto da Silveira Ismênia Glauce de Oliveira da Silva Neto Jorge Alves da Silva Ferreira Jéssica Silva Tatiane Severo Holanda Ioná Santos Araújo 《Molecular biology reports》2021,48(10):6887-6895
Molecular Biology Reports - Leprosy is a chronic infectious disease caused by Mycobacterium leprae and persists as a serious public health problem in Brazil. This microorganism is inculturable,... 相似文献
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9.
Photodynamic inactivation is a new promising approach to treat bacterial infections. Usually, the evaluation of the efficacy
of this method is done through time-consuming and labor-intensive microbiological test methods. This paper describes the development
and implementation of an optical method to evaluate the photodynamic inactivation of bacteria based on non-invasive diffuse
reflectance measurements. Five Staphylococcus aureus cultures and 15 mice have been used in this study. A skin lesion was created on the back of all animals, and it was contaminated
with S. aureus (5.16 ± 0.013 log CFU/ml). Toluidine Blue O (c = 8.67 × 10 − 3 M) has been used as a photosensitiser agent. The bacterial cultures and animals were exposed to laser radiation (λ = 635 nm, P = 15 mW, DE = 8.654 J/cm2) for 20 min. The photodynamic inactivation of bacteria was monitored by acquiring the wounds’ reflection spectra at different
time points and by microbiological exams on the bioptical material. The good correlation between the diffuse reflectance and
colony-forming units demonstrates the value of this optical method based on diffuse reflectance measurements as a rapid technique
to monitor photodynamic bacterial inactivation. 相似文献
10.
Galectin-1 (Gal-1), a mammalian lectin induces apoptosis of T lymphocytes. Contradictory data have resulted in confusing knowledge regarding mechanism of Gal-1 induced T-cell apoptosis. In this paper we aimed to resolve this controversy by comparing cell death induced by low (1.8 μM, lowGal-1) and high (18 μM, highGal-1) concentration of soluble Gal-1. We show that lowGal-1 and highGal-1 trigger phosphatidylserine exposure, generation of rafts and mitochondrial membrane depolarization. In contrast, lowGal-1 but not highGal-1 is dependent on the presence of p56lck and ZAP70 and activates caspase cascade. The results allow the conclusion that the cell-death mechanism strictly depends on the concentration of Gal-1. 相似文献