排序方式: 共有20条查询结果,搜索用时 0 毫秒
1.
Virologica Sinica - Influenza A viruses (IAV) are responsible for seasonal flu epidemics, which can lead to high morbidity and mortality each year. Like other viruses, influenza virus can hijack... 相似文献
2.
DNA复制是最基本的生命活动之一。DNA复制本身的错误及其过程控制的异常是细胞内基因组不稳定的主要来源,会导致细胞生长异常、衰老、癌变乃至死亡。为了保证基因组DNA能够精确且完整的复制,DNA复制受到严格的调控。在G1期,DNA复制解旋酶的核心组分Mcm2-7复合体被招募到复制起点,获得复制许可资格。进入S期后,在两个周期性蛋白激酶及多个支架蛋白的作用下,复制解旋酶的激活因子Cdc45和GINS复合体被招募至Mcm2-7,形成解旋酶全酶Cdc45-Mcm2-7-GINS (CMG)复合体。随后,众多复制相关蛋白在精准的时空控制下被招募至CMG平台并组装成复制机器,起始DNA双向复制。当相向而行的两个复制叉相遇,复制机器会从DNA链上解离下来,从而完成DNA复制。关于DNA复制过程的研究在近十年来取得了跨越式的突破。本文以酿酒酵母为例,围绕所有真核生物中都高度保守的DNA复制控制开关——CMG解旋酶,对真核生物DNA复制的最新进展进行综述。 相似文献
3.
Barrett DG Catalano JG Deaton DN Long ST McFadyen RB Miller AB Miller LR Samano V Tavares FX Wells-Knecht KJ Wright LL Zhou HQ 《Bioorganic & medicinal chemistry letters》2007,17(1):22-27
Starting from a potent ketone-based inhibitor with poor drug properties, incorporation of P(2)-P(3) elements from a ketoamide-based inhibitor led to the identification of a hybrid series of ketone-based cathepsin K inhibitors with better oral bioavailability than the starting ketone. 相似文献
4.
Wang YX Li YH Li YH Gao RM Wang HQ Liu YX Gao LM Lu QN Jiang JD Song DQ 《Bioorganic & medicinal chemistry letters》2011,21(19):5787-5790
Currently, there is no approved antiviral drug for the infection caused by enteroviruses. A series of novel N-arylethyl isoquinoline derivatives defined with substituents on the ring A and C were designed, synthesized and evaluated in vitro for their activities against Coxsackievirus B3 (CVB3). The primary structure-activity relationship revealed that substituents on the ring A were not beneficial for the activity. Among these analogs synthesized, compound 7f bearing a methylenedioxy at the R(4) and R(5) positions afforded an anti-CVB3 activity and a reasonable selectivity index (SI=26.8); furthermore, 7f exhibited a moderate activity against enterovirus 71 (EV71) with SI value of 9.0. Thus it has been selected as an anti-enteroviral lead compound for further investigation. 相似文献
5.
Yao Z Qiu S Wang L Lu R Zhou CL Zhao PP Li HQ Gao WY 《Cancer immunology, immunotherapy : CII》2006,55(1):56-60
Tyroserleutide (YSL) is a type of active, low molecular weight polypeptide, comprised of three amino acids, which has antitumor
effects. YSL has various advantages over the other bioactive peptides such as its low molecular weight, simple construction,
nonimmunogenicity, specificity, few side effects, and ease of synthesis. However, the biological activities contributing to
it’s antitumor effects are not yet known. We studied the effects of YSL on the in vitro cytotoxic activity of BALB/c mice
peritoneal macrophages (PEMφ) against the target tumor cell lines BEL-7402 and B16-F10. We also measured the concentrations
of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and nitric oxide (NO) produced by YSL-activated Mφ, and we determined
the concentrations of IL-1β and NO secreted by YSL-activated murine macrophage RAW264.7 cells. YSL activated Mφ in vitro,
inhibited BEL-7402 proliferation, enhanced PEMφ antitumor effects, and stimulated IL-1β, TNF-α, and NO production by RAW264.7
cells. These data suggest that YSL activates the monocyte–macrophage system, which enhances Mφ antitumor effects against BEL-7402
and B16-F10 cells and stimulates the secretion by Mφ of cytotoxic effectors such as IL-1β, TNF-α, and NO. 相似文献
6.
7.
Xiao-Feng He Jie Wei Zhi-Zhong Liu Jian-Jun Xie Wei Wang Ya-Ping Du Yu Chen Hui-Qiang Si Qing Liu Li-Xia Wu Wu Wei 《PloS one》2014,9(8)
Background
The previous published data on the association between CYP1A2*F (rs762551), CYP1B1 Leu432Val (rs1056836), Asn453Ser (rs180040), and Arg48Gly (rs10012) polymorphisms and colorectal cancer risk remained controversial.Methodology/Principal Findings
The purpose of this study is to evaluate the role of CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly genotypes in colorectal cancer susceptibility. We performed a meta-analysis on all the eligible studies that provided 5,817 cases and 6,544 controls for CYP1A2*F (from 13 studies), 9219 cases and 10406 controls for CYP1B1 Leu432Val (from 12 studies), 6840 cases and 7761 controls for CYP1B1 Asn453Ser (from 8 studies), and 4302 cases and 4791 controls for CYP1B1Arg48Gly (from 6 studies). Overall, no significant association was found between CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly and colorectal cancer risk when all the eligible studies were pooled into the meta-analysis. And in the subgroup by ethnicity and source of controls, no evidence of significant association was observed in any subgroup analysis.Conclusions/Significance
In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association. In addition, our work also points out the importance of new studies for CYP1A2*F polymorphism in Asians, because high heterogeneity was found (dominant model: I 2 = 81.3%; heterozygote model: I 2 = 79.0). 相似文献8.
Barrett DG Boncek VM Catalano JG Deaton DN Hassell AM Jurgensen CH Long ST McFadyen RB Miller AB Miller LR Payne JA Ray JA Samano V Shewchuk LM Tavares FX Wells-Knecht KJ Willard DH Wright LL Zhou HQ 《Bioorganic & medicinal chemistry letters》2005,15(15):3540-3546
An orally bioavailable series of ketoamide-based cathepsin K inhibitors with good pharmacokinetic properties has been identified. Starting from a potent inhibitor endowed with poor drug properties, conformational constraint of the P(2)-P(3) linker and modifications to P(1') elements led to an enhancement in potency, solubility, clearance, and bioavailability. These optimized inhibitors attenuated bone resorption in a rat TPTX hypocalcemic bone resorption model. 相似文献
9.