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1.
Daw-Yang Hwang Stefan Kohl Xueping Fan Asaf Vivante Stefanie Chan Gabriel C. Dworschak Julian Schulz Albertien M. van Eerde Alina C. Hilger Heon Yung Gee Tracie Pennimpede Bernhard G. Herrmann Glenn van de Hoek Kirsten Y. Renkema Christoph Schell Tobias B. Huber Heiko M. Reutter Neveen A. Soliman Natasa Stajic Radovan Bogdanovic Elijah O. Kehinde Richard P. Lifton Velibor Tasic Weining Lu Friedhelm Hildebrandt 《Human genetics》2015,134(8):905-916
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Hairless (H) is the major antagonist within the Notch signalling pathway of Drosophila melanogaster. By binding to Suppressor of Hairless [Su(H)] and two co-repressors, H induces silencing of Notch target genes in the absence of Notch signals. We have applied genomic engineering to create several new H alleles. To this end the endogenous H locus was replaced with an attP site by homologous recombination, serving as a landing platform for subsequent site directed integration of different H constructs. This way we generated a complete H knock out allele H
attP, reintroduced a wild type H genomic and a cDNA-construct (H
gwt, H
cwt) as well as two constructs encoding H proteins defective of Su(H) binding (H
LD, H
iD). Phenotypes regarding viability, bristle and wing development were recorded, and the expression of Notch target genes wingless and cut was analysed in mutant wing discs or in mutant cell clones. Moreover, genetic interactions with Notch (N
5419) and Delta (Dl
B2) mutants were addressed. Overall, phenotypes were largely as expected: both H
LD and H
iD were similar to the H
attP null allele, indicating that most of H activity requires the binding of Su(H). Both rescue constructs H
gwt and H
cwt were homozygous viable without phenotype. Unexpectedly, the hemizygous condition uncovered that they were not identical to the wild type allele: notably H
cwt showed a markedly reduced activity, suggesting the presence of as yet unidentified regulatory or stabilizing elements in untranslated regions of the H gene. Interestingly, H
gwt homozygous cells expressed higher levels of H protein, perhaps unravelling gene-by-environment interactions. 相似文献
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T Bendix F B Jessen J Winkel 《European journal of applied physiology and occupational physiology》1986,55(1):30-36
The amount of spontaneous movement during seated office work was estimated by analysing the tilting movements of a tiltable office chair. Both movement frequency and amplitude range were considered. The seat inclinations and subjective acceptability were also recorded. The seat was moved more frequently and with a greater range when adjusted 6 cm above popliteal level compared to 1 cm below, or when the backrest was pushed anteriorly or posteriorly compared to a middle position. The greatest acceptability occurred with the highest seat adjustment and the backrest in the middle position. Typing or desk-work influenced movement to a similar extent. 相似文献
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miRNAs in human subcutaneous adipose tissue: Effects of weight loss induced by hypocaloric diet and exercise 下载免费PDF全文
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Dimitra Alexopoulou Bill Andreopoulos Heiko Dietze Andreas Doms Fabien Gandon J?rg Hakenberg Khaled Khelif Michael Schroeder Thomas W?chter 《BMC bioinformatics》2009,10(1):28
Background
Ontology term labels can be ambiguous and have multiple senses. While this is no problem for human annotators, it is a challenge to automated methods, which identify ontology terms in text. Classical approaches to word sense disambiguation use co-occurring words or terms. However, most treat ontologies as simple terminologies, without making use of the ontology structure or the semantic similarity between terms. Another useful source of information for disambiguation are metadata. Here, we systematically compare three approaches to word sense disambiguation, which use ontologies and metadata, respectively. 相似文献9.
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