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1.
E. Azizi A. R. Deslauriers N. C. Holt C. E. Eaton 《Biomechanics and modeling in mechanobiology》2017,16(5):1633-1643
The collagenous extracellular matrix (ECM) of skeletal muscle functions to transmit force, protect sensitive structures, and generate passive tension to resist stretch. The mechanical properties of the ECM change with age, atrophy, and neuromuscular pathologies, resulting in an increase in the relative amount of collagen and an increase in stiffness. Although numerous studies have focused on the effect of muscle fibrosis on passive muscle stiffness, few have examined how these structural changes may compromise contractile performance. Here we combine a mathematical model and experimental manipulations to examine how changes in the mechanical properties of the ECM constrain the ability of muscle fibers and fascicles to radially expand and how such a constraint may limit active muscle shortening. We model the mechanical interaction between a contracting muscle and the ECM using a constant volume, pressurized, fiber-wound cylinder. Our model shows that as the proportion of a muscle cross section made up of ECM increases, the muscle’s ability to expand radially is compromised, which in turn restricts muscle shortening. In our experiments, we use a physical constraint placed around the muscle to restrict radial expansion during a contraction. Our experimental results are consistent with model predictions and show that muscles restricted from radial expansion undergo less shortening and generate less mechanical work under identical loads and stimulation conditions. This work highlights the intimate mechanical interaction between contractile and connective tissue structures within skeletal muscle and shows how a deviation from a healthy, well-tuned relationship can compromise performance. 相似文献
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I. S. Voroshilova 《Biology Bulletin》2016,43(10):1301-1307
This review summarizes published data on the genetic markers used in studies of dreissenide invasions. Causes of genetic differences between local populations are discussed. It is shown that information about the genetic diversity of populations obtained by marker polymorphism analysis should be compared to study invasion directions. 相似文献
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C N Koller L S Bauer R M Hollingworth 《Biochemical and biophysical research communications》1992,184(2):692-699
Native crystals of Bacillus thuringiensis var. san diego, a coleopteran-specific delta-endotoxin, were metabolically labelled with [35S]methionine. Specific activity was 82,000 CPM/micrograms (2.44 Ci/mmol). Using a universal buffer formulated with the same ionic strength at every pH, we determined that native crystals dissolve above pH 10 and below pH 4. At the acidic pH, the rate of solubilization was substantially slower than at the alkaline pH. Recrystallization rates for the toxin were similar regardless of solubilization conditions. The banding patterns in denatured polyacrylamide gel electrophoresis were unaffected by solubilization conditions. Toxicity was higher for soluble toxin compared to crystal toxin, but virtually identical for the acidic and alkaline produced solutions. Acid solubilization is significant because of the acidic midgut of susceptible Coleoptera. 相似文献
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Paul M. Severns 《Journal of Insect Conservation》2008,12(6):651-661
Fender’s blue butterfly is an endangered species restricted to fragmented, grassland remnants that are becoming increasingly
dominated by tall, invasive grasses in western Oregon, USA. I performed a removal experiment to assess the impacts of structural
degradation accompanying the invasion of Arrhenatherum elatius, tall oat grass, on butterfly fitness and fitness related behaviors. Clipping of A. elatius to native grass sward height resulted in 2.5–5 times as many eggs laid per leaf of host plant. Both male and female butterflies
basked more frequently in areas removed of A. elatius inflorescences and upon encountering the treatment edge butterflies had a high rate of return into a large area removed of
the grass inflorescences. Although butterfly behavior appeared to be affected by the change in sward height on the treatment
edge, there was no evidence for the edge causing a disproportionate egg load. Invasion and dominance by A. elatius appeared to diminish host plant apparency which may result in overloading of eggs on conspicuous host plants, increased incidence
of emigration, and a decrease in the likelihood of colonization because female butterflies appeared indifferent to larval
resources beneath A. elatius inflorescences. Dominance of natural shortgrass prairies by tall stature grasses like A. elatius may be an insidious form of habitat degradation for grassland Lepidoptera worldwide, but it may go largely unnoticed because
larval and adult resources can persist under the unnaturally tall grass canopy. 相似文献
10.
The significance of teaching to the evolution of human culture is under debate. We contribute to the discussion by using a quantitative, cross-cultural comparative approach to investigate the role of teaching in the lives of children in two small-scale societies: Aka foragers and Ngandu farmers of the Central African Republic. Focal follows with behavior coding were used to record social learning experiences of children aged 4 to 16 during daily life. “Teaching” was coded based on a functional definition from evolutionary biology. Frequencies, contexts, and subtypes of teaching as well as the identity of teachers were analyzed. Teaching was rare compared to observational learning, although both forms of social learning were negatively correlated with age. Children received teaching from a variety of individuals, and they also engaged in teaching. Several teaching types were observed, including instruction, negative feedback, and commands. Statistical differences in the distribution of teaching types and the identity of teachers corresponded with contrasting forager vs. farmer foundational cultural schema. For example, Aka children received less instruction, which empirically limits autonomous learning, and were as likely to receive instruction and negative feedback from other children as they were from adults. Commands, however, exhibited a different pattern suggesting a more complex role for this teaching type. Although consistent with claims that teaching is relatively rare in small-scale societies, this evidence supports the conclusion that teaching is a universal, early emerging cognitive ability in humans. However, culture (e.g., values for autonomy and egalitarianism) structures the nature of teaching. 相似文献