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1.
A cancer microenvironment generates strong hydrogen bond network system by the positive feedback loops supporting cancer complexity and robustness. Such network functions through the AKT locus generating high entropic energy supporting cancer metastatic robustness. Charged lepton particle muon follows the rule of Bragg effect during a collision with hydrogen network in cancer cells. Muon beam dismantles hydrogen bond network in cancer by the muon-catalyzed fusion, leading to apoptosis of cancer cells. Muon induces cumulative energy appearance on the hydrogen bond network in a cancer cell with its fast decay to an electron and two neutrinos. Thus, muon beam, muonic atom, muon neutrino shower, and electrons simultaneously cause fast neutralization of the AKT hydrogen bond network by the conversion of hydrogen into deuterium or helium, inactivating the hydrogen bond networks and inducing failure of cancer complexity and robustness with the disappearance of a malignant phenotype. 相似文献
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A case of chromomycosis in which hyperthermia proved effective is reported. The patient was a 56-year-old male bean curd maker who, without any previous history of minor trauma, developed on the extensor side of the left upper arm an eczematous lesion that underwent gradual radial expansion. The lesion showed a well-defined, 7×10 cm infiltrated erythematous plaque with the central area healed and, at the upper and lower borders, adherent scales and crusts on the surface. Histological examination revealed granulomatous changes in the dermis, as well as sclerotic cells within giant cells and microabscesses. On culturing,Fonsecaea pedrosoi was isolated. The patient was treated with disposable chemical pocket warmers, which were secured over the lesion with a rather tight elastic bandage, so that they kept the affected area warm for 24 hours a day. After a month of such hyperthermic treatment, the erythema and infiltration had decreased considerably, and microscopic examination and culture of the crusts both yielded negative results. Examination of biopsy specimens of the lesion after the third month showed that it had cicatrized. The treatment was stopped after 4 months, and no relapse occurred. We also summarize the published results of local hyperthermic treatment of chromomycosis in Japan. 相似文献
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Cheng Qian MD Danqi Chang MD Hang Li MD Yanggan Wang 《Journal of cellular biochemistry》2019,120(5):7771-7777
Heart failure (HF) remains a common complication after acute ST-segment elevation myocardial infarction (STEMI). Here, we aim to identify critical genes related to the developed HF in patients with STEMI using bioinformatics analysis. The microarray data of GSE59867, including peripheral blood samples from nine patients with post-infarct HF and eight patients without post-infarct HF, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between HF and non-HF groups were screened by LIMMA package. Functional enrichment analyses of DEGs were conducted, followed by construction of a protein-protein interaction (PPI) network. The dynamic messenger RNA (mRNA) level of the hub genes during the follow-up was analyzed to further elucidate their role in HF development. A total of 58 upregulated and 75 downregulated DEGs were screen out. They were mainly enriched in biological processes about inflammatory response, extracellular matrix organization, response to cAMP, immune response, and positive regulation of cytosolic calcium ion concentration. Pathway analysis revealed that the DEGs were also involved in hematopoietic cell lineage, pathways in cancer, and extracellular matrix-receptor interaction. In the PPI network consisting of 58 nodes and 72 interactions, CXCL8 (degree = 15), THBS1 (degree = 8), FOS (degree = 7), and ITGA2B (degree = 6) were identified as the hub genes. In the comparison of patients with and without post-infarct HF, the mRNA level of these hub genes were all higher within 30 days but reached similar at 6 months after STEMI. In conclusion, CXCL8, THBS1, FOS, and ITGA2B may play important roles in the development of HF after acute STEMI. 相似文献
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Aziz Sancar Neil D. Clarke Jonathan Griswold William J. Kennedy W.Dean Rupp 《Journal of molecular biology》1981,148(1):63-76
We have constructed plasmids carrying various restriction fragments of the biouvrB region of the Escherichia coli chromosome. By analyzing the proteins synthesized in maxicells from the uvrB+ plasmid pDR1494, and its derivatives containing γδ sequences inserted in the uvrB gene, we have determined that the uvrB gene is about two kilobase-pairs in length, that it is transcribed clockwise on the standard E. coli genetic map, and that it codes for a single polypeptide of Mr = 84,000. The number of uvrB polypeptides in a normal cell is estimated to be about 140.We have also found that the uvrB gene is cut by EcoRI near its promoter. 相似文献
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Hannah Marie Wood Charles E. Griswold Rosemary G. Gillespie 《Cladistics : the international journal of the Willi Hennig Society》2012,28(6):598-626
Phylogenetic relationships among archaeid spider lineages, as well as the placement of archaeids within the Araneomorphae, present a problem in the systematics of spiders. We investigate these relationships by broadly sampling taxa from the Araneomorphae and superfamily Palpimanoidea, as well as from extant and fossil archaeid lineages. Using parsimony and Bayesian methods we perform a total‐evidence analysis that includes 126 morphological characters and over 4000 bases from one mitochondrial and three nuclear molecular markers. Phylogenetic analysis results in a delimitation of the superfamily Palpimanoidea to contain five families: Archaeidae, Mecysmaucheniidae, Stenochilidae, Palpimanidae and Huttoniidae. We also find the extant archaeids, which are restricted to the southern hemisphere, to be monophyletic, with the fossil archaeids paraphyletic. This phylogenetic framework is then used to interpret a novel morphological character, the highly modified and elevated cephalic area and elongated chelicerae (jaws), coupled with prey choice observations in the field and observations of chelicerae movements during predatory attacks. We conclude that the evolution of the elevated cephalic area, which reoriented the chelicerae muscles, led to highly manoeuvrable chelicerae and associated novel prey capture strategies. All members of Palpimanoidea appear to have modifications to the cephalic area, such as a diastema or sclerotization around the chelicerae bases, and furthermore, members appear to have evolved prey specialization. 相似文献
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Felipe V Freitas Michael G Branstetter Terry Griswold Eduardo A B Almeida 《Molecular biology and evolution》2021,38(3):1090
Incongruence among phylogenetic results has become a common occurrence in analyses of genome-scale data sets. Incongruence originates from uncertainty in underlying evolutionary processes (e.g., incomplete lineage sorting) and from difficulties in determining the best analytical approaches for each situation. To overcome these difficulties, more studies are needed that identify incongruences and demonstrate practical ways to confidently resolve them. Here, we present results of a phylogenomic study based on the analysis 197 taxa and 2,526 ultraconserved element (UCE) loci. We investigate evolutionary relationships of Eucerinae, a diverse subfamily of apid bees (relatives of honey bees and bumble bees) with >1,200 species. We sampled representatives of all tribes within the group and >80% of genera, including two mysterious South American genera, Chilimalopsis and Teratognatha. Initial analysis of the UCE data revealed two conflicting hypotheses for relationships among tribes. To resolve the incongruence, we tested concatenation and species tree approaches and used a variety of additional strategies including locus filtering, partitioned gene-trees searches, and gene-based topological tests. We show that within-locus partitioning improves gene tree and subsequent species-tree estimation, and that this approach, confidently resolves the incongruence observed in our data set. After exploring our proposed analytical strategy on eucerine bees, we validated its efficacy to resolve hard phylogenetic problems by implementing it on a published UCE data set of Adephaga (Insecta: Coleoptera). Our results provide a robust phylogenetic hypothesis for Eucerinae and demonstrate a practical strategy for resolving incongruence in other phylogenomic data sets. 相似文献
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