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Interferon antibodies in patients with infectious diseases 总被引:2,自引:0,他引:2
G. Antonelli E. Simeoni M. Currenti F. De Pisa V. Colizzi M. Pistello F. Dianzani 《Biotherapy》1997,10(1):7-14
Interferons (IFNs) are generally recognized as the most important therapeutic agent in some infectious diseases such as chronic
hepatitis B and C. Since the early clinical trials it was documented that the therapeutic use of IFNs could be complicated
by the development of antibodies able to neutralize or to bind to the IFN molecule.
After several years of research it is now widely accepted that the presence of circulating anti-IFN antibodies may affect
the response to IFN.
Here we summarize what is currently know on the clinical significance of antibodies to IFN in IFN-treated viral diseases patients. 相似文献
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Vincenzo Amico Rosario Currenti Giovanna Oriente Mario Piattelli Corrado Tringali 《Phytochemistry》1981,20(6):1451-1453
The major lipid component of the brown seaweed Zonaria tournefortii was identified as the acylphlorogluconol (all Z)-2′-icosa-5,8,11,14,17-pentae 相似文献
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Pearce Tristan D. Manuel Lui Leon Javier Currenti Renee Brown Matthew Ikurisaru Ilaitia Doran Brendan Scanlon Halena Ford James 《Human ecology: an interdisciplinary journal》2021,49(5):579-594
Human Ecology - Biophysical impacts tend to dominate environmental impact assessments (EIA), yet social values of the environment have an important role to play in decision-making. To foster the... 相似文献
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Anaerobic bioconversion of cellulose by Ruminococcus albus, Methanobrevibacter smithii, and Methanosarcina barkeri 总被引:1,自引:0,他引:1
A system is described that combines the fermentation of cellulose to acetate, CH4, and CO2 by Ruminococcus albus and Methanobrevibacter smithii with the fermentation of acetate to CH4 and CO2 by Methanosarcina barkeri to convert cellulose to CH4 and CO2. A cellulose-containing medium was pumped into a co-culture of the cellulolytic R. albus and the H2-using methanogen, Mb. smithii. The effluent was fed into a holding reservoir, adjusted to pH 4.5, and then pumped into a culture of Ms. barkeri maintained at constant volume by pumping out culture contents. Fermentation of 1% cellulose to CH4 and CO2 was accomplished during 132 days of operation with retention times (RTs) of the Ms. barkeri culture of 7.5–3.8 days. Rates of acetate utilization were 9.5–17.3 mmol l−1 day−1 and increased with decreasing RT. The K
s for acetate utilization was 6–8 mM. The two-stage system can be used as a model system for studying biological and physical
parameters that influence the bioconversion process. Our results suggest that manipulating the different phases of cellulose
fermentation separately can effectively balance the pH and ionic requirements of the acid-producing phase with the acid-using
phase of the overall fermentation.
Received: 7 December 1999 / Received revision: 28 April 2000 / Accepted: 19 May 2000 相似文献
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Salvatore A. Currenti 《Cellular and molecular neurobiology》2010,30(2):161-171
Worldwide, the rate of autism has been steadily rising. There are several environmental factors in concert with genetic susceptibilities
that are contributing to this rise. Impaired methylation and mutations of mecp2 have been associated with autistic spectrum disorders, and related Rett syndrome. Genetic polymorphisms of cytochrome P450
enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism. Vitamin D
is important for neuronal growth and neurodevelopment, and defects in metabolism or deficiency have been implicated in autistic
individuals. Other factors that have been considered include: maternally derived antibodies, maternal infection, heavy metal
exposure, folic acid supplementation, epigenetics, measles, mumps, rubella vaccination, and even electromagnetic radiation.
In each case, the consequences, whether direct or indirect, negatively affect the nervous system, neurodevelopment, and environmental
responsive genes. The etiology of autism is a topic of controversial debate, while researchers strive to achieve a common
objective. The goal is to identify the cause(s) of autism to understand the complex interplay between environment and gene
regulation. There is optimism that specific causes and risk factors will be identified. The results of future investigations
will facilitate enhanced screening, prevention, and therapy for “at risk” and autistic patients. 相似文献
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