全文获取类型
收费全文 | 86篇 |
免费 | 8篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2019年 | 2篇 |
2018年 | 1篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 3篇 |
2012年 | 8篇 |
2011年 | 4篇 |
2010年 | 4篇 |
2009年 | 3篇 |
2008年 | 8篇 |
2007年 | 4篇 |
2006年 | 4篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1997年 | 2篇 |
1995年 | 2篇 |
1992年 | 3篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有94条查询结果,搜索用时 46 毫秒
1.
2.
Patrone Vania Al-Surrayai Tahani Romaniello Francesco Fontana Alessandra Milani Giovanni Sagheddu Valeria Puglisi Edoardo Callegari Maria Luisa Al-Mansour Hamad Kishk Mohamed Waheed Morelli Lorenzo 《Probiotics and antimicrobial proteins》2021,13(3):809-823
Probiotics and Antimicrobial Proteins - Probiotics represent a possible strategy for controlling intestinal infections in livestock. Members of the Weissella genus are increasingly being studied... 相似文献
3.
Beatriz Helena B. Vasconcelos Givago S. Souza Tatiana G. C. P. Barroso Luiz Carlos L. Silveira Rita Catarina M. Sousa Bianca Callegari Marília B. Xavier 《PloS one》2016,11(3)
Background
The human T-Cell Lymphotropic Virus Type 1 (HTLV-1) is a retrovirus associated with neurological alterations; individuals with HTLV-1 infection may develop HTLV-1 associated myelopathy / tropical spastic paraparesis (HAM/TSP). Frequent neurological complaints include foot numbness and leg weakness. In this study, we compared the distribution of the body weight on different areas of the foot in HTLV-1 patients with HAM/TSP, asymptomatic HTLV-1 patients, and healthy individuals.Methodology
We studied 36 HTLV-1 infected patients, who were divided in two groups of 18 patients each based on whether or not they had been diagnosed with HAM/TSP, and 17 control subjects. The evaluation included an interview on the patient’s clinical history and examinations of the patient’s reflexes, foot skin tactile sensitivity, and risk of falling. The pressure distribution on different areas of the foot was measured with baropodometry, using a pressure platform, while the patients had their eyes open or closed.Main Findings
The prevalence of neurological disturbances—altered reflexes and skin tactile sensitivity and increased risk of falling—was higher in HTLV-1 HAM/TSP patients than in HTLV-1 asymptomatic patients. The medium and maximum pressure values were higher in the forefoot than in the midfoot and hindfoot in both HTLV-1 groups. In addition, the pressure on the hindfoot was lower in HAM/TSP patients compared to control subjects.Conclusions
The neurological disturbances associated with HTLV-1 infection gradually worsened from HTLV-1 asymptomatic patients to HAM/TSP patients. Baropodometry is a valuable tool to establish the extent of neurological damage in patients suffering from HTLV-1 infection. 相似文献4.
Luciana Tovo‐Rodrigues Sidia M. Callegari‐Jacques M. Luiza Petzl‐Erler Luiza Tsuneto Francisco M. Salzano Mara H. Hutz 《American journal of physical anthropology》2010,143(3):458-464
The DRD4 variable number of tandem repeats (VNTR) allele distribution of 172 Guarani (Kaiowá and Ñandeva subgroups) and Kaingang Brazilian Amerindians is reported. These results are integrated with those previously obtained for this ethnic group. Allele frequencies for the three populations are within the interval observed for 15 other Native American populations and show intermediate values between those observed in Amazonia and Patagonia. Significant differences in allele distribution between recent past hunter–gatherer and agriculturalist populations are observed, with an increase of the 7R allele among hunter–gatherers (P < 0.001). Analysis of molecular variance (AMOVA) and pairwise FST data suggest three distinct sectors for the genetic landscape of Native South America: Andes, Center/Southeast region, and Amazonia. Common traits among hunter–gatherers such as novelty‐seeking temperament, hyperactivity, and impulsivity could have been important and advantageous in new environments during America's prehistoric colonization. Am J Phys Anthropol, 2010. © 2010 Wiley‐Liss, Inc. 相似文献
5.
6.
Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth 下载免费PDF全文
Adinolfi E Callegari MG Ferrari D Bolognesi C Minelli M Wieckowski MR Pinton P Rizzuto R Di Virgilio F 《Molecular biology of the cell》2005,16(7):3260-3272
P2X7 is a bifunctional receptor (P2X7R) for extracellular ATP that, depending on the level of activation, forms a cation-selective channel or a large conductance nonselective pore. The P2X7R has a strong proapoptotic activity but can also support growth. Here, we describe the mechanism involved in growth stimulation. Transfection of P2X7R increases resting mitochondrial potential (delta psi(mt)), basal mitochondrial Ca2+ ([Ca2+]mt), intracellular ATP content, and confers ability to grow in the absence of serum. These changes require a full pore-forming function, because they are abolished in cells transfected with a mutated P2X7R that retains channel activity but cannot form the nonselective pore, and depend on an autocrine/paracrine tonic stimulation by secreted ATP. On the other hand, sustained stimulation of P2X7R causes a delta psi(mt) drop, a large increase in [Ca2+]mt, mitochondrial fragmentation, and cell death. These findings reveal a hitherto undescribed mechanism for growth stimulation by a plasma membrane pore. 相似文献
7.
Eduardo?A?Callegari Susan?Ferguson-Gottschall Geula?GiboriEmail author 《Reproductive biology and endocrinology : RB&E》2005,3(1):3
In the rat, the decidual tissue is an important component for maternal recognition of pregnancy. Decidualization can be induced
by either the implantation of the blastocyst or by artificial stimuli. The process of decidua formation or decidualization,
is characterized by growth and differentiation of endometrial stromal cells. Prostaglandin F2alpha (PGF2α) has been shown
to be involved in inhibition of implantation, alteration of embryo development, induction of luteal regression, and the mediation
of pregnancy loss induced by microorganism infections. In order to establish a direct role for PGF2α in decidual function,
we have evaluated its effects on the expression of an extensive array of genes using primary decidual cell culture. Upon treatment
with PGF2α sixty genes were significantly down-regulated whereas only six genes were up-regulated (from a total of 1176 genes
studied). Interestingly, the majority of the genes inhibited by PGF2α are either directly or indirectly involved in the turnover
of the extracellular matrix (ECM). Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2)
and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator
(tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated. The opposite effect was observed
for prostromelysin 53 kDa (proMMP3), plasma proteinase I alpha and alpha 1 antiproteinase, all of which were significantly
up-regulated by PGF2α. The results strongly suggest that the abortificient role of elevated levels of PGF2α after implantation
is due, in large part, to inhibition of genes involved in the normal turnover of the extracellular matrix necessary for decidual
formation. 相似文献
8.
Elli M Callegari ML Ferrari S Bessi E Cattivelli D Soldi S Morelli L Goupil Feuillerat N Antoine JM 《Applied and environmental microbiology》2006,72(7):5113-5117
Whether Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus can be recovered after passage through the human gut was tested by feeding 20 healthy volunteers commercial yogurt. Yogurt bacteria were found in human feces, suggesting that they can survive transit in the gastrointestinal tract. 相似文献
9.
Marina Elli Maria Luisa Callegari Susanna Ferrari Elena Bessi Daniela Cattivelli Sara Soldi Lorenzo Morelli Nathalie Goupil Feuillerat Jean-Michel Antoine 《Applied microbiology》2006,72(7):5113-5117
Whether Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus can be recovered after passage through the human gut was tested by feeding 20 healthy volunteers commercial yogurt. Yogurt bacteria were found in human feces, suggesting that they can survive transit in the gastrointestinal tract. 相似文献
10.
Norata GD Venu VK Callegari E Paloschi V Catapano AL 《Biochimica et biophysica acta》2012,1822(6):927-935
The reduced expression (haplodeficiency) of the main brain derived neurotrophic factor receptor, namely TrkB is associated with reduced atherosclerosis, smooth muscle cells accumulation and collagen content in the lesion. These data support the concept that brain derived neurotrophic factor of vascular origin may contribute to atherosclerosis. However, to date, no experimental approach was possible to investigate this issue due to the lethality of brain derived neurotrophic factor null mice. To overcome these limitations, we generated a mouse model with a conditional deletion of brain derived neurotrophic factor in endothelial cells (Tie-2 Cre recombinase) on an atherosclerotic prone background (apolipoprotein E knock out) and investigated the effect of conditional brain derived neurotrophic factor deficiency on atherosclerosis. Despite brain derived neurotrophic factor reduction in the vascular wall, mice with conditional deletion of brain derived neurotrophic factor did not develop larger atherosclerotic lesion compared to controls. Smooth muscle cell content as well as the distribution of total and fibrillar collagen was similar in the atherosclerotic lesions from mice with brain derived neurotrophic factor conditional deficiency compared to controls. Finally an extended gene expression analysis failed to identify pro-atherogenic gene expression patterns among the animal with brain derived neurotrophic factor deficiency. In spite of the reduced brain derived neurotrophic factor expression, similar atherosclerosis development was observed in the brain derived neurotrophic factor conditional deficient mouse compared to controls. These pieces of evidence indicate that endothelial derived-brain derived neurotrophic factor is not a pro-atherogenic factor and would rather suggest to investigate the role of other TrkB activators on atherosclerosis. 相似文献