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1.
Zarrati Mitra Raji Lahiji Mahsa Salehi Eisa Yazdani Bahareh Razmpoosh Elham Shokouhi Shoormasti Raheleh Shidfar Farzad 《Probiotics and antimicrobial proteins》2019,11(4):1202-1209
Probiotics and Antimicrobial Proteins - Data on the effects of probiotics on adipokines such as omentin-1, nesfatin-1, and adropin are limited. The aim of this study was to evaluate the effects of... 相似文献
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Pourmoghadasiyan Bahareh Tavakkoli Fatemeh Beram Farzaneh Mahmoudi Badmasti Farzad Mirzaie Amir Kazempour Reza Rahimi Shahrzad Larijani Setare Farokhi Hejabi Faranak Sedaghatnia Kamand 《Molecular biology reports》2022,49(5):3597-3608
Molecular Biology Reports - In this study, the optimized niosomal formulation containing paclitaxel using non-ionic surfactants and cholesterol was designed and its cytotoxic effects against... 相似文献
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Bahareh Honarparvar Sachin A Pawar Cláudio Nahum Alves Jer?nimo Lameira Glenn EM Maguire José Rogério A Silva Thavendran Govender Hendrik G Kruger 《Journal of biomedical science》2015,22(1)
Background
Novel pentacycloundecane (PCU)-lactone-CO-EAIS peptide inhibitors were designed, synthesized, and evaluated against wild-type C-South African (C-SA) HIV-1 protease. Three compounds are reported herein, two of which displayed IC50 values of less than 1.00 μM. A comparative MM-PB(GB)SA binding free energy of solvation values of PCU-lactam and lactone models and their enantiomers as well as the PCU-lactam-NH-EAIS and lactone-CO-EAIS peptide inhibitors and their corresponding diastereomers complexed with South African HIV protease (C-SA) was performed. This will enable us to rationalize the considerable difference between inhibitory concentration (IC50) of PCU-lactam-NH-EAIS and PCU-lactone-CO-EAIS peptides.Results
The PCU-lactam model exhibited more negative calculated binding free energies of solvation than the PCU-lactone model. The same trend was observed for the PCU-peptide inhibitors, which correspond to the experimental activities for the PCU-lactam-NH-EAIS peptide (IC50 = 0.076 μM) and the PCU-lactone-CO-EAIS peptide inhibitors (IC50 = 0.850 μM). Furthermore, a density functional theory (DFT) study on the natural atomic charges of the nitrogen and oxygen atoms of the three PCU-lactam, PCU-lactim and PCU-lactone models were performed using natural bond orbital (NBO) analysis. Electrostatic potential maps were also used to visualize the electron density around electron-rich regions. The asymmetry parameter (η) and quadrupole coupling constant (χ) values of the nitrogen and oxygen nuclei of the model compounds were calculated at the same level of theory. Electronic molecular properties including polarizability and electric dipole moments were also calculated and compared. The Gibbs theoretical free solvation energies of solvation (∆Gsolv) were also considered.Conclusions
A general trend is observed that the lactam species appears to have a larger negative charge distribution around the heteroatoms, larger quadrupole constant, dipole moment and better solvation energy, in comparison to the PCU-lactone model. It can be argued that these characteristics will ensure better eletronic interaction between the lactam and the receptor, corresponding to the observed HIV protease activities in terms of experimental IC50 data.Electronic supplementary material
The online version of this article (doi:10.1186/s12929-015-0115-5) contains supplementary material, which is available to authorized users. 相似文献5.
Nafiseh Yousefi Abdolkarim Chehregani Behrouz Malayeri Bahareh Lorestani Mehrdad Cheraghi 《Biological trace element research》2011,140(3):368-376
Excessive amounts of heavy metals adversely affect plant growth and development. Whereas some regions naturally contain high
levels of heavy metals, anthropogenic release of heavy metals into the environment continuously increases soil contamination.
Preliminary studies have shown that Chenopodium botrys can grow in some heavy metal contaminated soils and is a high accumulator plant species for Cu and moderately accumulator
plant species for Fe, Mn, and Zn, thus, was considered as an important species in this study. Based on that, in this species,
we studied the individual effects of heavy metals on the formation, development, and structure of anther and pollen. To achieve
this purpose, surrounding area of Hame-Kasi iron and copper mine (Hamedan, Iran) was chosen as a polluted area where the amount
of some heavy metals was several times higher than the natural soils. Flowers and young pods were removed from non-polluted
and polluted plants, fixed in FAA 70, and subjected to developmental studies. Analysis of anther development in plants from
contaminated sites showed general similarities in the pattern of pollen formation with those from non-polluted ones, but also
deviation from typical form of major stages of anther and pollen development was seen in plants from polluted ones. Stabilizing
of tapetum layer, increasing in tapetum layer numbers, thickening callose wall in the microspore mother cell stage, changing
the anther shape, and decreasing the size of anther were the effects of heavy metals. Reduction of pollen number was also
seen in the plants collected from polluted area. 相似文献
6.
Arezou Sayad Soudeh Ghafouri-Fard Bahareh Shams Shahram Arsang-Jang Leila Gholami Mohammad Taheri 《Journal of cellular physiology》2020,235(12):9568-9576
Periodontitis is a complex disorder that affects a large number of human beings from different ethnic groups. This condition has been associated with dysregulation of a number of genes, among them are long noncoding RNAs (lncRNAs). In the current study, we assessed the expression of four lncRNAs (BDNF-AS, MIAT, MIR137HG, and PNKY) as well as BDNF in the peripheral blood and gingival tissues obtained from patients with periodontitis and healthy subjects. The expression of BDNF was significantly lower in blood samples of male patients with periodontitis compared with male controls (posterior β of RE = −4.754, p = .048). However, there was no significant difference in the expression of BDNF in tissue samples from the cases and controls. The expression of BDNF-AS was significantly lower in the tissue samples of patients compared with control tissue samples (posterior β of RE = −2.151, p = .019). Such an expression difference was detected between male subgroups as well (posterior β of RE = −3.679, p = .009). However, expression of this lncRNA was not different in blood samples obtained from patients compared with healthy subjects. The expression of PNKY was significantly higher in tissue samples obtained from female patients compared with sex-matched controls (posterior β of RE = 6.23, p = .037). Blood levels of this lncRNA were not different between cases and controls. There was no significant difference either in the tissue expression or in blood expression of MIR137HG or MIAT between cases and controls. The current study indicates the putative role of BDNF, BDNF-AS, and PNKY in the pathophysiology of periodontitis and potentiates these genes as candidates for functional studies. 相似文献
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Nasri Elahe Shoaei Parisa Vakili Bahareh Mirhendi Hossein Sadeghi Somayeh Hajiahmadi Somayeh Sadeghi Alireza Vaezi Afsane Badali Hamid Fakhim Hamed 《Mycopathologia》2020,185(6):1077-1084
Mycopathologia - Although patients with severe immunodeficiency and hematological malignancies has been considered at highest risk for invasive fungal infection, patients with severe pneumonia due... 相似文献
8.
Bahareh Khodashenas Mehdi Ardjmand Azim Akbarzadeh Khiyavi 《Journal of biomolecular structure & dynamics》2020,38(15):4644-4654
AbstractCommunicated by Ramaswamy H. Sarma 相似文献
9.
Leila Sadeghi Khosro Khajeh Nasrin Mollania Bahareh Dabirmanesh Bijan Ranjbar 《Molecular biotechnology》2013,53(3):270-277
It is the common feature of α-amylases that calcium ion is required for their structural integrity and thermal stability. All amylases have at least one Ca2+ per molecule; therefore amino acids involved in calcium binding are specific and conserved. In this study, sequence analysis revealed the presence of EF-hand-like motif in calcium-binding loop of Bacillus megaterium WHO (BMW)-amylase that was previously isolated from BMW. The EF-hand motif and its variants (EF-hand-like motif) are the most common calcium-binding motifs found in a large number of protein families. To investigate the effect of calcium ion on the thermal stability and activity of BMW-amylase, we used site-directed mutagenesis to replace histidine 58 with Asp (D), Ile (I), Tyr (Y), Phe (F), and Arg (R) at the seventh position of EF-hand-like motif. Upon the addition of an extra DX unit to the calcium-binding loop in H58D variant, thermal stability, catalytic activity, and chelating power of the enzyme improved due to higher affinity toward calcium. H58D variant demonstrated calcium independency compared to the wild type and other created mutants. Conformational changes in the presence and absence of Ca2+ were monitored using fluorescence technique. 相似文献