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Youssef Dalia El-Bakatoushi Ranya Elframawy Asmaa El-Sadek Laila Badan Ghada El 《Journal of plant research》2023,136(3):305-322
Journal of Plant Research - The current study examined the phylogenetic pattern of medicinal species of the family Apiaceae based on flavonoid groups production, as well as the overall mechanism of... 相似文献
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Sehrawat B Sridharan M Ghosh S Robson P Cass CE Mackey JR Greiner R Damaraju S 《Human genetics》2011,130(4):529-537
Previous genome-wide association studies (GWAS) have shown several risk alleles to be associated with breast cancer. However,
the variants identified so far contribute to only a small proportion of disease risk. The objective of our GWAS was to identify
additional novel breast cancer susceptibility variants and to replicate these findings in an independent cohort. We performed
a two-stage association study in a cohort of 3,064 women from Alberta, Canada. In Stage I, we interrogated 906,600 single
nucleotide polymorphisms (SNPs) on Affymetrix SNP 6.0 arrays using 348 breast cancer cases and 348 controls. We used single-locus
association tests to determine statistical significance for the observed differences in allele frequencies between cases and
controls. In Stage II, we attempted to replicate 35 significant markers identified in Stage I in an independent study of 1,153
cases and 1,215 controls. Genotyping of Stage II samples was done using Sequenom Mass-ARRAY iPlex platform. Six loci from
four different gene regions (chromosomes 4, 5, 16 and 19) showed statistically significant differences between cases and controls
in both Stage I and Stage II testing, and also in joint analysis. The identified variants were from EDNRA, ROPN1L, C16orf61 and ZNF577 gene regions. The presented joint analyses from the two-stage study design were not significant after genome-wide correction. The SNPs
identified in this study may serve as potential candidate loci for breast cancer risk in a further replication study in Stage
III from Alberta population or independent validation in Caucasian cohorts elsewhere. 相似文献
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Markan S Sachdeva M Sehrawat BS Kumari S Jain S Khullar M 《Molecular and cellular biochemistry》2007,302(1-2):125-131
The goals of our present study were to measure plasma homocysteine levels and determine their association with methylenetetrahydrofolate
reductase (MTHFR) gene polymorphisms (C677T and A1298C) in essential hypertensive subjects. Plasma total homocysteine and
folic acid levels were measured in essential hypertensive patients (n = 153) before and after oral supplementation with either 5 mg folic acid tablet/day or 5 mg placebo/day for 4 weeks and compared
with age and sex matched normotensive controls (n = 133). MTHFR gene polymorphisms (C677T and A1298C) were studied by restriction fragment length polymorphism and correlated
with plasma homocysteine levels. Homocysteine levels were significantly higher in hypertensive patients as compared to controls
and showed a negative correlation with plasma folate levels. Folic acid supplementation (5 mg/day) for 4 weeks resulted in
a significant decrease in plasma homocysteine concentrations in these patients. Patients carrying MTHFR 677T allele (OR = 1.90;
95%CI: 1.14–3.19) or MTHFR 1298C (OR = 2.6, 95%CI: 1.55–4.40) allele were at increased risk of hypertension. The frequency
of co-occurrence of MTHFR 677 CT/1298 CC genotypes was significantly higher in the patients compared to controls (P < 0.05) and was associated with increased risk of hypertension (OR = 3.54, 95%CI: 0.37–4.30). Subjects with MTHFR 1298 CC
genotype had significantly higher homocysteine levels compared to those with MTHFR 1298 AA genotype (P < 0.05). Our results indicate that MTHFR 677T and 1298C alleles and co-occurrence of MTHFR 677 CT/MTHFR 1298 CC genotypes
are associated with increased risk of hypertension and MTHFR 1298 CC genotype is associated with higher homocysteine levels
in our subjects. 相似文献
4.
Ana Paula Badan Ribeiro Renato Grimaldi Luiz Antonio Gioielli Adenilson Oliveira dos Santos Lisandro Pavie Cardoso Lireny A. Guaraldo Gonçalves 《Food biophysics》2009,4(2):106-118
Blends of soybean oil (SO) and fully hydrogenated soybean oil (FHSBO), with 10, 20, 30, 40, and 50% (w/w) FHSBO content were interesterified under the following conditions: 20 min reaction time, 0.4% sodium methoxide catalyst,
and 500 rpm stirring speed, at 100 °C. The original and interesterified blends were examined for triacylglycerol composition,
thermal behavior, microstructure, crystallization kinetics, and polymorphism. Interesterification produced substantial rearrangement
of the triacylglycerol species in all the blends, reduction of trisaturated triacylglycerol content and increase in monounsaturated–disaturated
and diunsaturated–monosaturated triacylglycerols. Evaluation of thermal behavior parameters showed linear relations with FHSBO
content in the original blends. Blend melting and crystallization thermograms were significantly modified by the randomization.
Interesterification caused significant reductions in maximum crystal diameter in all blends, in addition to modifying crystal
morphology. Characterization of crystallization kinetics revealed that crystal formation induction period (τ
SFC) and maximum solid fat content (SFCmáx) were altered according to FHSBO content in the original blends and as a result of the random rearrangement. Changes in Avrami
constant (k) and exponent (n) indicated, respectively, that—as compared with the original blends—interesterification decreased crystallization velocities
and modified crystallization processes, altering crystalline morphology and nucleation mechanism. X-ray diffraction analyses
revealed that interesterification altered crystalline polymorphism. The interesterified blends showed a predominance of the
β′ polymorph, which is of more interest for food applications. 相似文献
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Kashyap MK Yadav V Sherawat BS Jain S Kumari S Khullar M Sharma PC Nath R 《Molecular and cellular biochemistry》2005,277(1-2):89-99
Hypertension is a multi-factorial process, prevalent in developed as well as in developing countries. Different antioxidants and free radicals play an important role in cardiovascular system. In present study, total antioxidant power in terms of FRAP (ferric reducing activity of plasma), free radicals and different antioxidants have been studied in essential hypertensives (n = 50) and normal subjects (n = 50). Levels of total cholesterol, low-density lipids-cholesterol, malonialdehyde, very low-density lipids (VLDL), uric acid, plasma homocysteine and low-density lipids (LDL), were significantly higher in hypertensives as compared to normotensive. HDL-cholesterol, SOD, GPx, reduced glutahione, total glutathione, oxidized glutathione, total thiols, protein thiols, non protein thiols, RNI, total antioxidant power, vitamin A, ascorbic acid and glutahione-S-transferase (GST) were decreased significantly in normotensive. We observed significantly low nitric oxide levels in hypertensive patients. No correlation was observed between severity of disease and plasma nitric oxide levels. There was a significant decrease in plasma FRAP value in essential hypertensives as compared to normotensive controls, which showed a negative correlation with diastolic blood pressure. In conclusion, our study revealed that there was a consistent significant difference between essential hypertensives versus controls with respect to most of the parameters. These complex changes are consistent in the view that essential hypertension is associated with an abnormal level of antioxidant status compared to normal response to oxidative stress or both. 相似文献
6.
Mello Natália Aparecida Cardoso Lisandro Pavie Ribeiro Ana Paula Badan Bicas Juliano Lemos 《Food biophysics》2021,16(1):1-14
Food Biophysics - Due to its hard consistency and low plasticity, palm stearin (PS) has limited industrial applications. As described in the literature, the addition of limonene... 相似文献
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