Synthesis and Evaluation of Novel Isoindoline-1,3-dione Derivatives as Anticancer Agents

Russian Journal of Bioorganic Chemistry - N-Substituted imides, isoindoline-1,3-dione derivatives, were synthesized, characterized, and investigated against blood cancer using K562 and Raji cell...     

Relationship between high CRP and cytokines in Saudi old people with dental caries in alkharj Region,Saudi Arabia

ObjectiveDental caries is one of the most common problems of the oral cavity which is frequently observed in older people. The aim of this study is to evaluate serum C-reactive proteins (CRP) levels and to identify the correlation between dental caries and CRP levels.MethodologyThe study included 12 aged patients with an average age of 65-years; the patients were diagnosed with dental caries and did not have clinical history of heart diseases, rheumatoid arthritis or any other infection. The control group consisted of 10 healthy donors with an average age of 60-years. The CRP level of positive samples was measured by using CRP Enzyme-linked immunosorbent assay-ELISA Kit.ResultsThe currents study showed that only 5 out of 12 patients were CRP positive.ConclusionsBecause of study limitations, it is early to conclude of close relationship between serum CRP and dental caries from the findings of this study; however, this study will give a clearer picture to understand the relationship between serum CRP, inflammatory cytokines and dental caries.