Matching models of left ventricle and systemic artery

To reveal how the matching models of the left ventricle and its afterload affect the pressure and flow in the aortic root, the differences between the measured pressure and flow waveforms and those determined by three kinds of matching model were compared. The results showed that, compared with the results by both matching models 1 and 2, the pressure and flow waveforms determined by matching model 3 established in this work were in the closest agreement with the corresponding experimental waveforms, therefore indicating that matching model 3 was a matching model that closely and rationally characterized the match between the left ventricle and the systemic artery.     

左心室与体动脉的匹配模型

为揭示左心室及其后负荷耦合模型如何影响主动脉根部的压力和流量,比较3种不同的匹配模型所确定压力和流量波形与实测波形的差异情况.结果表明,与匹配模型1和匹配模型2比之,所建立的匹配模型3所确定的压力和流量波形与相应的实验波形吻合得最好.说明匹配模型3是一种较合适表征左心室与体动脉匹配耦合的模型.     

Opening angles and residual strains in normal rat trachea

The no-load state and zero-stress state o1 the normal rat trachea were analyzed. It was found that there exist compressive residual strains in the inner wall region of the rat trachea and tensile residual strains in the outer wall region. The fact that the opening angle of the rat trachea cut at the cartilaginous region is significantly larger than that cut at the muscular portion shows that residual strains exist mainly in the muscular region in the rat trachea. It was also indicated that the opening angles and residual strains expressed by cutting at the muscular portion are basically identical along longitudinal location and those expressed by cutting in the cartilaginous region tend to increase in the longitudinal direction in the normal rat, and that there exists quantitatively positive correlation between the opening angles and residual strains in rat trachea. The results will help to further understand the opening angles and residual strains in the trachea and study tracheal remodeling in response     

Opening angles and residual strains in normal rat trachea

The no-load state and zero-stress state of the normal rat trachea were analyzed. It was found that there exist compressive residual strains in the inner wall region of the rat trachea and tensile residual strains in the outer wall region. The fact that the opening angle of the rat trachea cut at the cartilaginous region is significantly larger than that cut at the muscular portion shows that residual strains exist mainly in the muscular region in the rat trachea. It was also indicated that the opening angles and residual strains expressed by cutting at the muscular portion are basically identical along longitudinal location and those expressed by cutting in the cartilaginous region tend to increase in the longitudinal direction in the normal rat, and that there exists quantitatively positive correlation between the opening angles and residual strains in rat trachea. The results will help to further understand the opening angles and residual strains in the trachea and study tracheal remodeling in response to mechanical environment.     

大鼠气管软骨和肌肉残余应变研究

提出两次性剪开方法, 即沿着垂直于气管软骨切线方向剪开软骨和肌肉的两个连接点, 由此分别得到气管软骨和肌肉的零应力状态, 并定义了表征零应力状态的软骨和肌肉张开角. 通过检测得到的气管软骨和肌肉无载荷和零应力状态的几何信息, 计算软骨和肌肉内、外壁残余应变, 以及相应的张开角. 结果表明软骨外壁处存在拉伸残余应变, 内壁处存在压缩残余应变; 肌肉外壁处存在拉伸残余应变, 靠近气管杈的气管环肌肉内壁处存在压缩残余应变, 其余气管环肌肉的内壁处存在拉伸残余应变, 这和血管等组织不同. 结果还表明, 软骨的残余应变要比肌肉的小很多, 往往只是肌肉的十分之一左右; 软骨张开角和肌肉残余应变呈正相关关系; 无论是残余应变的绝对值还是张开角, 都随着气管环轴向位置的下移而减小. 所得结果不仅表明气管是一周向和轴向极为非均匀的生物材料, 而且显示气管的残余应变情况与血管、食管等组织不同, 是深入研究气管重建的基础.     

正常大鼠气管的张开角与残余应变

对正常大鼠气管的无载荷状态和零应力状态进行分析, 发现大鼠气管内壁存在压缩残余应变, 外壁存在拉伸残余应变; 软骨剪开的张开角明显大于肌肉剪开的张开角, 气管残余应变主要集中在气管的肌肉部分; 肌肉剪开的张开角和残余应变沿轴向基本不变, 软骨剪开的张开角和残余应变沿轴向呈上升趋势, 气管张开角与残余应变呈正相关的定量关系. 所得结果对深入认识气管零应力状态和残余应变, 研究气管为适应所处力学环境产生的气管重建有帮助.     

脑血管硬化程度的定量分析

本文利用从日本引进的QFM—1000型超声多普勒定量血流量仪,分别对正常老年组和病变老年组,检测了其颈动脉血流速、血流量和血管直径在一个心动周期中的变化波形,再利用非线性弹性腔理论,编制程序软件,通过计算机处理后,对脑血管床的硬化程度给出了脑血管总体顺应性Co,外周阻力R和特性阻抗Zc等一系列指标,经过对这些数据的统计分析后,发现这些表征动脉弹性的指标能很好地反映脑血管床的硬化程度,从而有可能对脑血管的硬化实现定量分析。由于该方法的检测手段是无创伤的,因此有可能广泛应用于脑血管疾病的预防与诊治,具有一定的临床意义。