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EA Dukhanina TI Lukyanova EA Romanova V Guerriero NV Gnuchev GP Georgiev DV Yashin LP Sashchenko 《Cell cycle (Georgetown, Tex.)》2015,14(22):3635-3643
PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response. 相似文献
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Carbon metabolism of P. chrysogenum under conditions of periodical addition of the nutrients was studied. It was found that a proper rate of the carbon source addition to the culture was of significant importance for intensive biosynthesis. The use of carbon for the energetic and constructive needs was not the same at different fermentation periods. 相似文献
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Popova N. A. Nikolaev Yu. A. Tourova T. P. Lysenko A. M. Osipov G. A. Verkhovtseva N. V. Panikov N. S. 《Microbiology》2002,71(3):335-341
The KT
2 strain of thermophilic spore-forming bacteria was isolated from a biofilm on the surface of a corroded pipeline in an extremely deep well (4680 m, 40–72°C) in the Urals. The cells are rod-shaped, motile, gram-variable. They grow on a complex medium with tryptone and yeast extract and on a synthetic medium with glucose and mineral salts without additional growth factors. The cells use a wide range of organic substances as carbon and energy sources. They exhibit a respiratory metabolism but are also capable of anaerobic growth on a nitrate-containing medium. Growth occurs within the 40–75°C temperature range (with an optimum of 65°C) and at pH 5–9. The minimum generation time (15 min) was observed at pH 7.5. Ammonium salts, nitrates, and arginine are used as nitrogen sources. The G+C content of the DNA is 54.5 mol %. From the morphological, physiological, and biochemical properties and the nucleotide sequence of the 16S rRNA gene, it was concluded that the isolate KT
2 represents a new species of the genus Geobacillus, Geobacillus uralicus. 相似文献
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G. V. Kondakova N. V. Verkhovtseva S. A. Ostroumov 《Moscow University Biological Sciences Bulletin》2013,68(3):119-123
The presence of viable hydrocarbon-oxidizing microorganisms has been shown in the under-ground waters exposed by the Vorotilovskaya deep well (the Puchezh-Katunki astrobleme, 75 km north of Nizhny Novgorod, 1900- and 3200-m deep) using the method of chromatography-mass spectrometry of specific biomarkers of the microbial cell wall and the classical methods of bacteriology. Several microbial species have been isolated in pure culture and identified. Two bacillary species, Bacillus pumilus KTB-2 and Bacillus subtilis KTB-4, were maintained in pure cultures at reinoculations. The effects of mineralization and aeration of the medium on the growth characteristics of Bacillus pumilus KTB-2 in batch culture have been studied. 相似文献
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We present an efficient computational architecture designed using supervised machine learning model to predict amyloid fibril
forming protein segments, named AmylPepPred. The proposed prediction model is based on bio-physio-chemical properties of
primary sequences and auto-correlation function of their amino acid indices. AmylPepPred provides a user friendly web interface
for the researchers to easily observe the fibril forming and non-fibril forming hexmers in a given protein sequence. We expect that
this stratagem will be highly encouraging in discovering fibril forming regions in proteins thereby benefit in finding therapeutic
agents that specifically aim these sequences for the inhibition and cure of amyloid illnesses.