A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1 |
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| Authors: | EA Dukhanina TI Lukyanova EA Romanova V Guerriero NV Gnuchev GP Georgiev DV Yashin LP Sashchenko |
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| Institution: | 1.Institute of Gene Biology; Russian Academy of Sciences (RAS); Moscow, Russia;2.Engelhardt Institute of Molecular Biology; RAS; Moscow, Russia;3.M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry; RAS; Moscow, Russia;4.School of Animal and Comparative Biomedical Sciences; University of Arizona; Tucson, AZ USA |
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| Abstract: | PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response. |
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| Keywords: | chemotaxis human lymphocytes Mts1 NK cells Tag7 Tag7-Mts1 complex |
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