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排序方式: 共有75条查询结果,搜索用时 78 毫秒
1.
EA Dukhanina TI Lukyanova EA Romanova V Guerriero NV Gnuchev GP Georgiev DV Yashin LP Sashchenko 《Cell cycle (Georgetown, Tex.)》2015,14(22):3635-3643
PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response. 相似文献
2.
G Gentile G Giraldo M Stabile E Beth-Giraldo F Lonardo S K Kyalwazi L Perone V Ventruto 《Annales de génétique》1987,30(3):164-169
A cell line of penile cancer from a 60-year-old Ugandan black patient has been studied by the authors. Transmission and scanning electron microscopy showed a large number of blebs and microvilli at cell surface; desmosomes were evident at TEM. Cytogenetic investigation (R-, C-, Nor-banding) showed the frequent presence of some markers: del(1p),del(1q),iso(3q),der(4),del(8p),11q+, t rob(13;14), 14p+, t rob(21;21). The epidemiology, geographical distribution, and aetiological role of human papilloma virus type 16 and herpes simplex type 2 are discussed. 相似文献
3.
t(21q21q)/r[t(21q21q)] mosaic in two unrelated patients with mild stigmata of Down's syndrome 总被引:4,自引:0,他引:4
B Dallapiccola I Bianco V Brinchi B Santulli G Scarano A Sicolo M Stabile V Ventruto 《Annales de génétique》1982,25(1):56-58
Two cases of t(21q21q)/r[t(21q21q)] mosaic in unrelated infants, 17 and 14 months old respectively are reported. The proportion of cells with the ring chromosome was 45% in the former, 80% in the latter. Both cases had mild manifestations of the Down's syndrome. The origin of this unusual mosaicism as well as the significance of the difference in the proportions of the ring chromosome in the two have been discussed. 相似文献
4.
Urbanization and habitat fragmentation can alter the timing of life history events, potentially leading to phenological mismatches, carryover effects, and fitness costs. Whereas urbanization and fragmentation are known to alter important aspects of breeding in many bird species, little is known about the effects of urbanization and habitat fragmentation on moult. To investigate the effects of urbanization and fragmentation on the annual moult, we compared the moult dynamics (onset, duration, and intensity) of urban, fragmented forest, and contiguous forest populations of the Carolina chickadee, a North American resident passerine that moults once per year immediately following the breeding season. Over three years, moult dynamics were similar in contiguous and fragmented forest populations, but wing moult started significantly earlier, and onset of moult varied less among years, in urban chickadees than in forest chickadees (fragmented and contiguous habitats pooled). Duration of wing moult did not differ between urban and forest populations, but urban birds moulted significantly fewer feathers simultaneously during peak moult, suggesting that individual feathers grew more rapidly. Our results show that urban living alters critical aspects of moult dynamics in a widespread songbird. Given the importance of moult dynamics for fitness during subsequent life history stages, and the large number of songbird species inhabiting urban areas, these results reveal previously unrecognized and potentially costly carryover effects of urban living on songbirds. 相似文献
5.
Indolfi C Torella D Coppola C Stabile E Esposito G Curcio A Pisani A Cavuto L Arcucci O Cireddu M Troncone G Chiariello M 《American journal of physiology. Heart and circulatory physiology》2002,283(2):H760-H767
The best animal angioplasty model is the porcine model, which is expensive and not available in all laboratories. The aim of this study was to describe a new rat model of angioplasty. An injury was induced with the use of a standard percutaneous transluminal coronary angioplasty (PTCA) 1.5-mm balloon catheter. The neointimal tissue, arterial dimensions, and the injury index were assessed following angioplasty. Ki-67 expression was detected to evaluate cell turnover after balloon angioplasty. In contrast with the standard Clowes model, a significant neointimal formation was detected only in the presence of ruptured internal elastic lamina (IEL). A positive correlation between the percentage of ruptured IEL and the amount of neointimal tissue was also demonstrated. The percentage of IEL fracture correlates with the proliferation index by anti-Ki-67 immunolabeling 7 and 14 days after the angioplasty. Significant arterial negative remodeling was observed following PTCA balloon dilation. In conclusion, our inexpensive animal model of restenosis after angioplasty may have great relevance toward a better understanding of the mechanisms and toward assessment of new therapeutical strategies for this phenomenon. 相似文献
6.
Isaac Wirgin Cheryl Grunwald Joseph Stabile John R. Waldman 《Conservation Genetics》2010,11(3):689-708
Shortnose sturgeon Acipenser brevirostrum is federally listed as ‘‘an endangered species threatened with extinction’’ in the U.S. but its listing status is currently
under review. As part of this process, the U.S. National Marine Fisheries Service will determine if shortnose sturgeon are
divided into Distinct Population Segments (DPS) across its distribution. In this regard, we sought to determine if shortnose
sturgeon occur in genetically “discrete population segments,” and if so, the boundaries of each. We used mitochondrial DNA
(mtDNA) control region sequence analysis to assess the genetic discreteness of 14 of 19 river populations that were recommended
as DPS in the 1998 Final Recovery Plan for Shortnose Sturgeon. Nine of the 14 proposed DPS proved significantly discrete (P < 0.05 after Bonferoni correction) from both of their bracketing populations, the exceptions being those in the Penobscot
River, Chesapeake Bay, Cooper River, and Ogeechee River (our sample from the Cape Fear River was insufficient to statistically
analyze). Haplotype frequencies in the newly “rediscovered” Penobscot River collection were almost identical to those in the
proximal Kennebec River system. Genetic data in combination with tagging results suggest that shortnose sturgeon in the Penobscot
River are probably migrants from the Kennebec. Likewise, shortnose sturgeon found today within the Chesapeake Bay appear to
be migrants from the Delaware River. While haplotype frequencies in the remnant Santee River population in Lake Marion differed
significantly from those in nearby Winyah Bay, they did not differ significantly from those in the Cooper River. This suggests
that the Cooper River harbors descendants of the Santee River population that are unable to access their historical spawning
locales. The Ogeechee River collection was not genetically distinct from that in the nearby Savannah River, suggesting that
it may host descendants of hatchery-reared individuals of Savannah River ancestry. Our genetic results indicate that most,
but not all, rivers with shortnose sturgeon host genetically discrete populations, constituting important information in the
consideration of DPS designations. However, shortnose sturgeon migrations through coastal waters to proximal rivers and release
of hatchery-reared fish may confound results from genetic studies such as ours and lead to the possible misidentification
of discrete population segments. 相似文献
7.
Background
Elucidation of the communal behavior of microbes in mixed species biofilms may have a major impact on understanding infectious diseases and for the therapeutics. Although, the structure and the properties of monospecies biofilms and their role in disease have been extensively studied during the last decade, the interactions within mixed biofilms consisting of bacteria and fungi such as Candida spp. have not been illustrated in depth. Hence, the aim of this study was to evaluate the interspecies interactions of Pseudomonas aeruginosa and six different species of Candida comprising C. albicans, C. glabrata, C. krusei, C. tropicalis, C. parapsilosis, and C. dubliniensis in dual species biofilm development. 相似文献8.
Myerburg MM Latoche JD McKenna EE Stabile LP Siegfried JS Feghali-Bostwick CA Pilewski JM 《American journal of physiology. Lung cellular and molecular physiology》2007,292(6):L1352-L1360
The luminal airway surface is lined with epithelial cells that provide a protective barrier from the external environment and clear inhaled pathogens from the lung. To accomplish this important function, human bronchial epithelial (HBE) cells must be able to rapidly regenerate a mucociliary layer of cells following epithelial injury. Whereas epithelial-fibroblast interactions are known to modulate the airway architecture during lung development and repair, little is known about how these two cells interact. Using a primary HBE and lung fibroblast coculture system, we demonstrate that 1) subepithelial fibroblasts provide a suitable environment for differentiation of HBE cells into a polarized ciliated phenotype despite being cultured in media that induces terminal squamous differentiation and growth arrest in the absence of fibroblasts, 2) HBE cells cocultured with subepithelial fibroblasts exhibit augmented ciliogenesis, accelerated wound repair, and diminished polarized ion transport compared with cells grown in control conditions, and 3) hepatocyte growth factor (HGF) is important for subepithelial fibroblast modulation of HBE cell differentiation. These results provide a model to study fibroblast modulation of epithelial phenotype and indicate that HGF secreted by subepithelial fibroblasts contributes to HBE cell differentiation. 相似文献
9.
Angel R Barchuk Alexandre S Cristino Robert Kucharski Luciano F Costa Zilá LP Simões Ryszard Maleszka 《BMC developmental biology》2007,7(1):70
Background
In honeybees, differential feeding of female larvae promotes the occurrence of two different phenotypes, a queen and a worker, from identical genotypes, through incremental alterations, which affect general growth, and character state alterations that result in the presence or absence of specific structures. Although previous studies revealed a link between incremental alterations and differential expression of physiometabolic genes, the molecular changes accompanying character state alterations remain unknown. 相似文献10.
Antoinette?C?van der KuylEmail author Donato?LP?Ballasina Fokla?Zorgdrager 《BMC evolutionary biology》2005,5(1):29