排序方式: 共有4条查询结果,搜索用时 15 毫秒
1
1.
Mohammad Taheri Arash Safarzadeh Arefe Bahranian Solat Eslami Nader Akbari Dilmaghani Soudeh Ghafouri-Fard Guive Sharifi 《Journal of cellular and molecular medicine》2023,27(11):1550-1556
Long non-coding RNAs (lncRNAs) have been shown to be dysregulated in a variety of malignant and non-malignant lesions including non-functioning pituitary adenomas (NFPAs). In the current experimental study, we have selected six lncRNAs, namely MAPKAPK5-AS1, NUTM2B-AS1, ST7-AS1, LIFR-AS1, PXN-AS1 and URB1-AS1 to assess their expression in a cohort of Iranian patients with NFPA. MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 were shown to be over-expressed in NFPA tissues compared with control samples (Expression ratios (95% CI) = 10 (3.94–25.36), 11.22 (4.3–28.8) and 9.33 (4.12–21.12); p values < 0.0001, respectively). The depicted ROC curves showed the AUC values of 0.73, 0.80 and 0.73 for MAPKAPK5-AS1, PXN-AS1 and URB1-AS1, respectively. Relative expression level of PXN-AS1 was associated with tumour subtype (p value = 0.49). Besides, relative expression levels of MAPKAPK5-AS1 and LIFR-AS1 were associated with gender of patients (p values = 0.043 and 0.01, respectively). Cumulatively, the current study indicates the possible role of MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 lncRNAs in the pathogenesis of NFPAs. 相似文献
2.
3.
Abolfazl Barzegari Mohammad Amin Hejazi Nahid Hosseinzadeh Solat Eslami Elnaz Mehdizadeh Aghdam Mohammad Saeid Hejazi 《Molecular biology reports》2010,37(7):3427-3430
Pharmaceutical recombinant proteins are widely used in human healthcare. At present, several protein expression systems are
available to generate therapeutic proteins. These conventional systems have distinct advantages and disadvantages in protein
yielding; in terms of ease of manipulation, the time required from gene transformation to protein purification, cost of production
and scaling-up capitalization, proper folding and stability of active proteins. Depending on the research goal and priorities,
a special system may be selected for protein expression. However, considering the limited variety of organisms currently used
and their usage restrictions, there are still much more pharmaceutical proteins waiting to be economically and efficiently
produced. Distinguished biological and technical features of microalgae Dunaliella such as inexpensive medium requirement,
fast growth rate, the ease of manipulation, easy scaling up procedure, facility of milking in bioreactors and the ability
of post-translational modifications make this microorganism an attractive candidate for molecular farming. 相似文献
4.
1