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V. Schuh 《Folia microbiologica》1965,10(3):156-162
The scarlet fever toxin is pyrogenically active. The pyretic reaction can be inhibited with antiserum bothin vitro andin vivo. From the quantitative aspect the pyrogenicity neutralization point corresponds approximately to the equivalence point of the flocculation reaction. The transmission of tolerance with the serum of tolerant animals failed. Tolerance was of short duration; interruption of the series of toxin injections for two days resulted in complete restoration of the animal's sensitivity. It is argued on the basis of these results that although tolerance carries signs of immunological specificity it cannot be explained in terms of circulating antibodies. 相似文献
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M. Kasper T. Reimann U. Hempel K.-W. Wenzel A. Bierhaus D. Schuh V. Dimmer G. Haroske M. Müller 《Histochemistry and cell biology》1997,109(1):41-48
Caveolin is a major structural protein of caveolae, also known as plasmalemmal vesicles, which are particularly abundant
in type I pneumocytes and capillary endothelial cells of lung parenchyma. Here we demonstrate that caveolin expression in
the alveolar epithelium of rats and mini pigs is strikingly downregulated after irradiation-induced lung injury. Indirect
immunoperoxidase staining with polyclonal anti-caveolin antibodies, confirmed by double fluorescence studies with type I cell-specific
monoclonal anti-cytokeratin antibodies or lectins, revealed a dramatic loss of caveolin immunoreactivity in type I pneumocytes.
In contrast, caveolin expression increased in endothelial cells. Immunoblotting of lung homogenates from normal and irradiated
rats using specific anti-caveolin antibodies confirmed the presence of caveolin in normal tissue and its marked decrease of
expression in fibrotic tissue. The loss of caveolin as an important structural protein of caveolae in alveolar epithelial
cells may be an early indicator of serious type I cell injury during fibrogenesis. The increase of caveolin immunoreactivity
in endothelia of blood vessels may indicate that different types of caveolae and/or different regulatory mechanisms of caveolin
expression exist.
Accepted: 28 May 1997 相似文献
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Magnesium-induced inner membrane aggregation in heart mitochondria: prevention and reversal by carboxyatractyloside and bongkrekic acid 下载免费PDF全文
Mg(2+) at an optimal concentration of 2mM (ph 6.5) induces large increases (up to 30 percent) in the optical density of bovine heart mitochondria incubated under conditions of low ionic strength (< approx. 0.01). The increases are associated with aggregation (sticking together) of the inner membranes and are little affected by changes in the energy status of the mitochondria. Virtually all of a number of other polyvalent cations tested and Ag(+) induce increases in mitochondrial optical density similar to those induced by Mg(2+), their approximate order of concentration effectiveness in respect to Mg(2+) being: La(3+) > Pb(2+) = Cu(2+) > Cd(2+) > Zn(2+) > Ag(+) > Mn(2+) > Ca(2+) > Mg(2+). With the exception of Mg(2+), all of these cations appear to induce swelling of the mitochondria concomitant with inner membrane aggregation. The inhibitors of the adenine nucleotide transport reaction carboxyatratyloside and bongkrekic acid are capable of preventing and reversing Mg(2+)-induced aggregation at the same low concentration required for complete inhibition of phosphorylating respiration, suggesting that they inhibit the aggregation by binding to the adenine nucleotide carrier. The findings are interpreted to indicate (a) that the inner mitochondrial membrane is normally prevented from aggregating by virtue of its net negative outer surface change, (b) that the cations induce the membrane to aggregate by binding at its outer surface, decreasing the net negative charge, and (c) that carboxyatractyloside and bongkrekic acid inhibit the aggregation by binding to the outer surface of the membrane, increasing the net negative charge. 相似文献
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J Schuh A Novogrodsky R H Haschemeyer 《Biochemical and biophysical research communications》1978,84(3):763-768
Mitogenic stimulation of lymphocytes is significantly inhibited by addition of human serum low-density lipoprotein that has undergone autoxidation, while no significant effect is seen with non-oxidized lipoprotein. The inhibition is effective for cells stimulated either by the plant lectin phytohemagglutinin or enzymatically by neuraminidase-galactose oxidase treatment. However, it is markedly attenuated when oxidized LDL is added to cells which have been triggered 24 hours earlier. Lipid extracts from oxidized LDL are similarly inhibitory, indicating that the effect is mediated by an oxidized lipid fraction. 相似文献
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Microsporida similar morphologically to Encephalitozoon cuniculi were found in granulomatous foci in the brain of 5 of 29 wild-caught muskrats (Ondatra zibethica) held in captivity for various periods of time, but not in any of 36 free-living muskrats examined. The significance and possible source of this infection are discussed. 相似文献