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排序方式: 共有109条查询结果,搜索用时 15 毫秒
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M D Aleinik V S Krivitskaia T F Riabikova E A Grinshtein I K Makarevich 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1979,(1):59-64
On the example of 4 cites of the RSFSR under conditions of expected epidemic threat a possibility was shown of directed influence on the viral hepatitis A epidemic process of preseasonal gamma-globulin prophylaxis conducted in 90% of "organized" children, aged from 1 to 12 years. The dose used was 0.75 ml of a 10% preparation. The method of Gorky Institute of Epidemiology and Microbiology was used to prognosticate the morbidity. It is recommended to improve the tactics of preseasonal gamma-globulin prophylaxis with consideration to the data of the viral hepatitis prognosis. 相似文献
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The effect of pH on the culture respiration rate at different concentrations of glucose in the medium was studied. It was found that the hydrogen ions showed their effect irrespective of the subsrate concentration in the medium. In this connection a type of macrokinetic equations of the effect of pH on the growth and antibiotic biosynthesis was chosen. The constants of the model were determined. 相似文献
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Gribovskaya O. V. Martinovich V. P. Makarevich D. A. Golubovich V. P. Ryabtseva T. V. Kirkovskiy V. V. 《Russian Journal of Bioorganic Chemistry》2020,46(2):165-170
Russian Journal of Bioorganic Chemistry - Molecular modeling, which identified several peptide sequences, was carried out in search for compounds capable of reducing the interleukin-8 concentration... 相似文献
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K.?V.?DergilevEmail author Z.?I.?Tsokolaeva K.?A.?Rubina V.?Yu.?Sysoeva P.?I.?Makarevich M.?A.?Boldyreva I.?B.?Beloglazova E.?S.?Zubkova G.?V.?Sharonov R.?S.?Akchurin Ye.?V.?Parfyonova 《Cell and Tissue Biology》2016,10(5):349-356
Resident cardiac stem cells, known as “cardiogenic progenitor cells” (CPCs), are a heterogeneous population of immature cells residing in the myocardium and capable of self-renewal and differentiation into cardiomyocyte-like and vascular-like cells. CPCs are usually isolated by long enzymatic digestion of heart tissue and selection with stem cell markers. However, long exposure to enzymatic digestion and the small size of a myocardial sample significantly hinder acquiring a large number of viable cells. To avoid these problems, we developed a method based on CPC growth ex vivo and subsequent immunomagnetic selection. 相似文献
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M. P. Venger A. I. Kopylov E. A. Zabotkina P. R. Makarevich 《Russian Journal of Marine Biology》2016,42(1):26-35
The viral and bacterioplankton communities of the Barents Sea were investigated using a combination of methods of electron and epifluorescence microscopy for the first time. The quantitative composition of the communities and the nature of their interactions were also determined. Our study showed that during the summer the abundance and biomass of bacterioplankton reached 0.4–4.0 × 106 cells/mL and 25.09–84.21 mg/m3 in offshore waters and 0.4–1.8 × 106 cells/mL and 19.63–100.19 mg/m3 in coastal waters, respectively. In both regions, the number of viruses (1.7–35.8 × 106 and 14.5–32.4 × 106 particles/mL) exceeded the number of bacteria by 2–31 and 13–60 times, respectively; the average viral production was 0.75106 and 1.74 × 106 particles/mL/day, respectively. The proportion of infected cells in the total bacterioplankton (7% on average) and virus-induced mortality of bacteria (8%) were much lower in offshore than in coastal waters (14 and 20%, respectively). 相似文献
7.
Pivko J Landa V Kubovicová E Supová A Grafenau P Makarevich AV Zibrín M 《General physiology and biophysics》2004,23(1):101-112
Early bovine precompacted embryos (at 1- to 8-blastomere stage) were analyzed by electron microscopy. The volume density of cellular components was determined by morphometric analysis to quantify the ultrastructure of early bovine embryos produced either in vivo or parthenogenetically after stimulation of oocytes by electric pulse AC/DC. In embryos obtained in vivo, most of cellular volume was occupied by cytoplasm (82.93%). The relative volume of lipids, vacuoles, mitochondria was relatively low (5.46; 5.07; 3.78%, respectively), and the relative volume of Golgi apparatus and cell inclusions was the lowest (1.51%). AC/DC-derived parthenogenotes had a relative high area occupied by vacuoles and lipids (18.68 vs. 14.33%) and a significantly lower relative volume was occupied by cytoplasm (60.63%) when compared with the control in vivo embryos. These observations demonstrated that parthenogenetic embryos had significantly altered ultrastructure, indicating extensive subcellular damages. These findings are discussed from the physiological and functional point of view. 相似文献
8.
Shnol' SE Rubinshteĭn IA Zenchenko KI Zenchenko TA Udal'tsova NV Kondradov AA Shapovalov SN Makarevich AV Gorshkov ES Troshichev OA 《Biofizika》2003,48(6):1123-1131
The detailed structure of histograms constructed from the results of synchronous measurements of the alpha-activity of 239Pu microsamples, conducted in Pushchino (Moscow Region, Russia) and on board the ship "Academician Fedorov" during the Arctic and Antarctic expeditions (2000 and 2001) was analyzed. It was shown that, if the histograms were constructed over a total period of 15 min and more, the "local zone effect" and the circadian periodicity in the similarity of histogram structure, observed during measurements in Pushchino, are not found in measurements on board the ship near the North Pole (latitude 82 degrees). If the histograms were constructed over a total time of 1 min, a strict periodicity ("stellar day" 23 h 56 min) in the appearance of similar histograms in Pushchino and the Arctic and a strict synchronicity of the appearance of similar histograms of measurements in Pushchino and on board the ship at the same local geographical time were observed. During the Antarctic expedition, the effect of synchronicity of the appearance of similar histograms in Pushchino and on board the ship decreased as the ship moved towards the South Pole and the difference in latitude between the points of measurements increased. 相似文献
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The role of cAMP/protein kinase A (PKA)- and tyrosine kinase (TK)-dependent intracellular mechanisms in mediating the action of porcine growth hormone (GH) on insulin-like growth factor I (IGF-I) secretion by porcine ovarian granulosa cells was studied. It was observed that GH-induced stimulation of IGF-I secretion was accompanied by an increase in cAMP production. The stimulation of PKA by the addition of either a cAMP agonist or a phosphodiesterase inhibitor to the medium increased IGF-I release by the cells, indicating a direct stimulation of IGF-I release by cyclic nucleotides. Moreover, the stimulatory effect of GH on IGF-I was completely suppressed by the addition of the PKA blocker Rp-cAMPS. Neither TK blocker altered the basal IGF-I level, but both strongly suppressed the GH-induced increase in IGF-I accumulation. Taken together, these findings suggest that cAMP/PKA- and/or TK-dependent pathways may be involved in the mediation of GH action on IGF-I release by porcine granulosa cells. 相似文献