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In summary, the reproductive cycles of C. minutas and C. brachyotis are shown in Fig. 12. Reproduction of both species is seasonal and continuous bimodal polyoestry, however, reproduction of neither species is linked to rains nor the general season of flowering/fruiting of trees.
Adult females of both species produce 2 litters/yr, 1 neonate/birth. Within each species, the females are in reproductive synchrony, with young born in two distinct seasons (3–4 months each) of parturition 5–7 months apart, centring about the two seasons of less rain, which may correspond to the fruiting of certain species of trees (e.g. mangoes for C. brachyotis ). Each parturition is followed by postpartum oestrus. Gestation spans about 5–6 months, with embryonic development delayed or arrested in early stages. Both sexes of C. minutas (and probably also C. brachyotis ) attain sexual maturity at about 7 months, with females giving birth the first time at about 12 months. 相似文献
Adult females of both species produce 2 litters/yr, 1 neonate/birth. Within each species, the females are in reproductive synchrony, with young born in two distinct seasons (3–4 months each) of parturition 5–7 months apart, centring about the two seasons of less rain, which may correspond to the fruiting of certain species of trees (e.g. mangoes for C. brachyotis ). Each parturition is followed by postpartum oestrus. Gestation spans about 5–6 months, with embryonic development delayed or arrested in early stages. Both sexes of C. minutas (and probably also C. brachyotis ) attain sexual maturity at about 7 months, with females giving birth the first time at about 12 months. 相似文献
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Protein- and gene-based tissue engineering in bone repair 总被引:9,自引:0,他引:9
A tissue engineering approach to bone regeneration includes the use of a scaffold, cells and bioactive factors alone or in various combinations. Several investigators have demonstrated enhanced bone formation when the tissue-engineered construct possesses traits inherent to autogenic bone grafts, namely osteoconductivity, osteoinductivity and osteogenicity. Use of the biodegradable polymer poly(lactide-co-glycolide) in combination with bone morphogenetic protein or primary cells genetically modified to release osteogenic protein have demonstrated the ability to induce osteogenic differentiation of, and subsequent mineralization by, muscle-derived cells and mesenchymal stem cells in both in vitro and in vivo applications. 相似文献
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Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin 总被引:1,自引:0,他引:1
Kofron M Birsoy B Houston D Tao Q Wylie C Heasman J 《Development (Cambridge, England)》2007,134(3):503-513
Current models of canonical Wnt signaling assume that a pathway is active if beta-catenin becomes nuclearly localized and Wnt target genes are transcribed. We show that, in Xenopus, maternal LRP6 is essential in such a pathway, playing a pivotal role in causing expression of the organizer genes siamois and Xnr3, and in establishing the dorsal axis. We provide evidence that LRP6 acts by degrading axin protein during the early cleavage stage of development. In the full-grown oocyte, before maturation, we find that axin levels are also regulated by Wnt11 and LRP6. In the oocyte, Wnt11 and/or LRP6 regulates axin to maintain beta-catenin at a low level, while in the embryo, asymmetrical Wnt11/LRP6 signaling stabilizes beta-catenin and enriches it on the dorsal side. This suggests that canonical Wnt signaling may not exist in simple off or on states, but may also include a third, steady-state, modality. 相似文献
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Virgilio G. Ponferrada Jieqing Fan Jefferson E. Vallance Shengyong Hu Aygun Mamedova Scott A. Rankin Matthew Kofron Aaron M. Zorn Rashmi S. Hegde Richard A. Lang 《PloS one》2012,7(3)
In multicellular organisms, morphogenesis is a highly coordinated process that requires dynamically regulated adhesion between cells. An excellent example of cellular morphogenesis is the formation of the neural tube from the flattened epithelium of the neural plate. Cysteine-rich motor neuron protein 1 (CRIM1) is a single-pass (type 1) transmembrane protein that is expressed in neural structures beginning at the neural plate stage. In the frog Xenopus laevis, loss of function studies using CRIM1 antisense morpholino oligonucleotides resulted in a failure of neural development. The CRIM1 knockdown phenotype was, in some cases, mild and resulted in perturbed neural fold morphogenesis. In severely affected embryos there was a dramatic failure of cell adhesion in the neural plate and complete absence of neural structures subsequently. Investigation of the mechanism of CRIM1 function revealed that it can form complexes with ß-catenin and cadherins, albeit indirectly, via the cytosolic domain. Consistent with this, CRIM1 knockdown resulted in diminished levels of cadherins and ß-catenin in junctional complexes in the neural plate. We conclude that CRIM1 is critical for cell-cell adhesion during neural development because it is required for the function of cadherin-dependent junctions. 相似文献