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1.
Flekhter O. B. Boreko E. I. Nigmatullina L. R. Pavlova N. I. Nikolaeva S. N. Savinova O. V. Eremin V. F. Baltina L. A. Galin F. Z. Tolstikov G. A. 《Russian Journal of Bioorganic Chemistry》2003,29(3):296-302
New nitrogen-containing derivatives of betulinic and betulonic acids, hydrazides and N"-benzalhydrazides, were synthesized. Their antiviral activities toward viruses of influenza A virus, herpes simplex type I virus, enterovirus ECHO6, and HIV-1 were studied in vitro. Betulinic acid 3-oxime was found to have the highest activity against the influenza virus. Betulonic acid, betulinic acid 4-chlorobenzalhydrazide, betulonic acid 3-oxime benzalhydrazide, and betulinic acid hydrazide inhibited the replication of herpes simplex type I virus. Betulinic acid hydrazide also showed antiviral activity toward HIV-1. All the derivatives of betulinic acid under study displayed a low antiviral activity toward enterovirus ECHO6. 相似文献
2.
Flekhter O. B. Karachurina L. T. Nigmatullina L. R. Sapozhnikova T. A. Baltina L. A. Zarudii F. S. Galin F. Z. Spirikhin L. V. Tolstikov G. A. Plyasunova O. A. Pokrovskii A. G. 《Russian Journal of Bioorganic Chemistry》2002,28(6):494-500
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3O,28O-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. 相似文献
3.
O. B. Flekhter L. T. Karachurina V. V. Poroikov L. P. Nigmatullina L. A. Baltina F. S. Zarudii V. A. Davydova L. V. Spirikhin I. P. Baikova F. Z. Galin G. A. Tolstikov 《Russian Journal of Bioorganic Chemistry》2000,26(3):192-200
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, andp-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin
esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor.
These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bishemiphthalate
was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol. 相似文献
4.
Flekhter O. B. Boreko E. I. Nigmatullina L. R. Tret'yakova E. V. Pavlova N. I. Baltina L. A. Nikolaeva S. N. Savinova O. V. Galin F. Z. Tolstikov G. A. 《Russian Journal of Bioorganic Chemistry》2003,29(6):594-600
Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containingL-Val and L-Met residues were found to be effective against herpes simplex type 1 virus. 相似文献
5.
O. B. Flekhter N. I. Medvedeva G.A. Tolstikov F. Z. Galin M. S. Yunusov Huong Nguen Thi Mai Le Viet Tien I. V. Savinova E. I. Boreko L. P. Titov I. V. Glukhov 《Russian Journal of Bioorganic Chemistry》2009,35(2):233-239
The rare olean-18(19)-ene triterpenoids moradiol and moronic acid were synthesized from betulin, and their antiviral properties were investigated. 相似文献
6.
Flekhter OB Boreko EI Nigmatullina LR Pavlova NI Nikolaeva SN Savinova OV Eremin VF Baltina LA Galin FZ Tolstikov GA 《Bioorganicheskaia khimiia》2003,29(3):326-332
New nitrogen-containing derivatives of betulinic and betulonic acids, hydrazides and N'-benzalhydrazides, were synthesized. Their antiviral activities toward of influenza A virus, herpes simplex type I virus, enterovirus ECHO6, and HIV-1 were studied in vitro. Betulinic acid 3-oxime was found to have the highest activity against the influenza virus. Betulonic acid, betulinic acid 4-chlorobenzalhydrazide, betulonic acid 3-oxime benzalhydrazide, and betulinic acid hydrazide inhibited the replication of herpes simplex type I virus. Betulinic acid hydrazide also showed antiviral activity toward HIV-1. All the derivatives of betulinic acid under study displayed a low antiviral activity toward enterovirus ECHO6. 相似文献
7.
Baltina LA Flekhter OB Nigmatullina LR Boreko EI Pavlova NI Nikolaeva SN Savinova OV Tolstikov GA 《Bioorganic & medicinal chemistry letters》2003,13(20):3549-3552
Betulin and betulinic acid have been modified at the C-3 and C-28 positions and the antiviral activity of derivatives has been evaluated in vitro. It was found that simple modifications of the parent structure of lupane triterpenes produced highly effective agents against influenza A and herpes simplex type 1 viruses. 相似文献
8.
Flekhter OB Boreko EI Nigmatullina LR Tret'iakova EV Pavlova NI Baltina LA Nikolaeva SN Savinova OV Galin FZ Tolstikov GA 《Bioorganicheskaia khimiia》2003,29(6):655-661
Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containing L-Val and L-Met residues were found to be effective against herpes simplex type 1 virus. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2003, vol. 29, no. 6; see also http://www.maik.ru. 相似文献
9.
Flekhter OB Boreko EI Tret'iakova EV Pavlova NI Baltina LA Nikolaeva SN Savinova OV Eremin VF Galin FZ Tolstikov GA 《Bioorganicheskaia khimiia》2004,30(1):89-98
Betulonic acid amides with aliphatic and heterocyclic amines and with L-amino acids were synthesized by the acid chloride method. Betulonic acid amide and L-methionine derivatives of betulonic acid and its 3-oxime effectively inhibit the influenza A virus. Betulonic acid octadecylamide is active against the herpes simplex type 1 virus. The conjugate of betulonic acid 3-oxime with L-methionine is also active toward HIV-1. The tested compounds mainly show no activity toward the ECHO6 virus, which is devoid of a coat. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru. 相似文献
10.
T. G. Tolstikova I. V. Sorokina G. A. Tolstikov A. G. Tolstikov O. B. Flekhter 《Russian Journal of Bioorganic Chemistry》2006,32(1):37-49
The biological activity of natural and semisynthetic lupane triterpenoids is discussed in a two-part review. The first part is devoted to the pharmacological properties of natural lupane triterpenoids. Betulinic acid has proven to be the most effective antitumor agent among more than fifty natural lupanes. 相似文献