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Aleksandrova NP Donina ZhA Tikhonov MA Baranov VM 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2007,93(6):670-677
The role of lung receptors in respiratory control during acute head-down tilt (AHDT, -30 degrees) was investigated in anesthetized, tracheostomized rats. The results show that AHDT increased the mechanical respiratory load, slowed inspiratory flow, reduced the end expiratory lung volume, tidal volume and minute ventilation. On the other hand, during AHDT a significant rise in inspiratory swings of oesophageal pressure was recorded indicated a compensatory increase in inspiratory muscle contraction force. These effects were reduced after transaction of the vagus nerve. It was also shown that respiratory response on added mechanical load was reduced during AHDT as compared with the value in horizontal position. This deference disappeared after vagotomy. The data obtained suggested that afferent information from lung receptors take part in compensation of respiratory effects of AHDT. The cause of reduction in respiratory response to loading during AHDT involves weakness of lung reflexes evoked by volume changes. 相似文献
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Donina ZhA Lavrova IN Tikhonov MA Kotov AN Kolesnikov VI Baranov VM 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2005,91(9):1091-1096
In ground-based model of the hemodynamics effects of weightlessness, the intersystem relation of breathing and circulation was investigated during inspiration and expiration separately in anesthetized catz. It's shown that the dynamics of central venous pressure, esophageal pressure and filling pressure of the heart during inspiration in supine and head-down tilt position has obvious similarity to those which hypothetically can be present in microgravity. The results suggest that intrathoracic hemodynamics during inspiration in supine and head-down position may be an adequate ground model for investigation of weightlessness influences on intrathoracic circulation. 相似文献
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Journal of Evolutionary Biochemistry and Physiology - The global pandemic of a new coronavirus disease (COVID-19) has posed challenges to public health specialists around the world associated with... 相似文献
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Pogodin MA Donina ZhA Lavrova IN Baranov VM Kotov AN Tikhonov MA 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2000,86(12):1587-1593
In anaesthetised cats, antiorthostatic posture of the body with an inclination angle of 30 degrees increased pressure in the vena cava superior and in jugular vein. The rest of the cardio-respiratory parameters were changed insignificantly. Physical and physiological mechanisms of the blood regional redistribution in alteration of the body gravitation orientation, are discussed. 相似文献
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Donina ZhA 《Fiziologiia cheloveka》2011,37(2):117-128
The review includes modern data about the functional interaction of respiratory and bloods circulatory systems in different conditions. The special attention is given to adaptive changes of respiratory and haemodynamic indices in extreme conditions. Based on the own researches physiological parallels between intersystem correlation of respiratory biomechanics and haemodynamics in the conditions of normal gravitation and weightlessness are drawn. 相似文献
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Donina Zh. A. Baranova E. V. Aleksandrova N. P. 《Journal of Evolutionary Biochemistry and Physiology》2021,57(4):936-944
Journal of Evolutionary Biochemistry and Physiology - A pressing issue of the day is the identification of therapeutic targets to suppress the “cytokine storm” in COVID-19 complicated... 相似文献
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Donina ZhA Lavrova IN Tikhonov MA Kotov AN Kolesnikov VI 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2006,92(8):997-1005
Cardiorespiratory responses induced by upright tilt before and after intermittent hypoxia during head-down tilt, were investigated in rabbits. Arterial blood pressure, heart rate, central venous pressure, transmural filling pressure of the heart (calculated as the product of esophageal and central venous pressure), breathing frequency, esophageal pressure were measured in supine (baseline), head-down and upright posture. Our results indicate a reduction in orthostatic responses in cardiovascular system after intermittent hypoxia. 相似文献
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