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排序方式: 共有219条查询结果,搜索用时 328 毫秒
1.
Ghaheri Matin Kahrizi Danial Bahrami Gholamreza Mohammadi-Motlagh Hamid-Reza 《Molecular biology reports》2019,46(1):7-16
Molecular Biology Reports - Stevia rebaudiana produces sweet steviol glycosides that are 300 times sweeter than sugar and have the beneficial effects on human health including anti-hyperglycaemic.... 相似文献
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C DeLuca-Flaherty K M Flaherty L J McIntosh B Bahrami D B McKay 《Journal of molecular biology》1988,200(4):749-750
A 44,000 Mr amino-terminal, clathrin-independent ATPase fragment of the bovine clathrin uncoating ATPase has been crystallized in a form suitable for X-ray diffraction studies. The crystals are orthorhombic, space group P2(1)2(1)2(1), a = 145.3 A, b = 65.0 A, c = 46.9 A, with one protein molecule per asymmetric unit (1 A = 0.1 nm). 相似文献
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Bahrami Armina Alagheband Bandehpour Mojgan Khalesi Bahman Kazemi Bahram 《International journal of peptide research and therapeutics》2020,26(1):389-403
International Journal of Peptide Research and Therapeutics - Infections with HCV, HBV and poliovirus are still considered to be substantial global health burdens. Vaccination is one of the most... 相似文献
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Saeed Bahrami Moqadam Ahamd Saleh Asheghabadi Farzaneh Norouzi Hamed Jafarzadeh Ali Khosroabadi Afshin Alagheband Ghazal Bangash Negar Morovatdar Jing Xu 《仿生工程学报(英文版)》2021,18(6):1344-1357
Lack of temperature sensation of myoelectric prosthetic hand limits the daily activities of amputees.To this end,a non-invasive temperature sensation method is proposed to train amputees to sense temperature with psychophysical sensory substitution.In this study,22 healthy participants took part besides 5 amputee participants.The duration time of the study was 31 days with five test steps according to the Leitner technique.An adjustable temperature mug and a Peltier were used to change the temperature of the water/phantom digits to induce temperature to participants.Also,to isolate the surround-ings and show colors,a Virtual Reality(VR)glass was employed.The statistical results conducted are based on the response of participants with questionnaire method.Using Chi-square tests,it is concluded that participants answer the experiment significantly correctly using the Leitner technique(P value<0.05).Also,by applying the"Repeated Measures ANOVA",it is noticed that the time of numbness felt by participants had significant(P value<0.001)difference.Participants could remember lowest and highest temperatures significantly better than other temperatures(P value<0.001);furthermore,the well-trained amputee participant practically using the prosthesis with 72.58%could identify object's temperature with only once time experimenting the color temperature. 相似文献
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A novel affinity biosensor is proposed based on the hybrid plasmonic platform. The proposed biosensor benefits from the high sensitivity of the surface plasmon resonance (SPR), while at the same time, it is capable of performing measurements in both the TM and TE polarizations (p- and s-polarizations). Unlike the conventional SPR biosensors, the polarization diversity of the hybrid sensor allows for decoupling of the bulk index variations in the fluidic channels (due to variations in concentration, decomposition, temperature, and so on) from the surface properties of the attached molecules. Compatibility of the proposed hybrid plasmonic biosensor with standard Si-processing techniques and the simplicity of its design are other advantages of the sensor which makes its fabrication straightforward. The best figure of merit for the biosensor is defined based on the minimum detection limit and a genetic algorithm is used to optimize the device. A method of de-convolving the surface and bulk effects is also discussed. 相似文献
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The somatotropic axis, the control system for growth hormone (GH) secretion and its endogenous factors involved in the regulation of metabolism and energy partitioning, has promising potentials for producing economically valuable traits in farm animals. Here we investigated single nucleotide polymorphisms (SNPs) of the genes of factors involved in the somatotropic axis for growth hormone (GH1), growth hormone receptor (GHR), ghrelin (GHRL), insulin-like growth factor 1 (IGF-I) and leptin (LEP), using polymerase chain reaction–single-strand conformation polymorphism (PCR–SSCP) and DNA sequencing methods in 452 individual Mehraban sheep. A nonradioactive method to allow SSCP detection was used for genomic DNA and PCR amplification of six fragments: exons 4 and 5 of GH1; exon 10 of GH receptor (GHR); exon 1 of ghrelin (GHRL); exon 1 of insulin-like growth factor-I (IGF-I), and exon 3 of leptin (LEP). Polymorphisms were detected in five of the six PCR products. Two electrophoretic patterns were detected for GH1 exon 4. Five conformational patterns were detected for GH1 exon 5 and LEP exon 3, and three for IGF-I exon 1. Only GHR and GHRL were monomorphic. Changes in protein structures due to variable SNPs were also analyzed. The results suggest that Mehraban sheep, a major breed that is important for the animal industry in Middle East countries, has high genetic variability, opening interesting prospects for future selection programs and preservation strategies. 相似文献
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Mahmood Amiri Narges Hosseinmardi Fariba Bahrami Mahyar Janahmadi 《Journal of computational neuroscience》2013,34(3):489-504
Neural synchronization is considered as an important mechanism for information processing. In addition, based on recent neurophysiologic findings, it is believed that astrocytes regulate the synaptic transmission of neuronal networks. Therefore, the present study focused on determining the functional contribution of astrocytes in neuronal synchrony using both computer simulations and extracellular field potential recordings. For computer simulations, as a first step, a minimal network model is constructed by connecting two Morris-Lecar neuronal models. In this minimal model, astrocyte-neuron interactions are considered in a functional-based procedure. Next, the minimal network is extended and a biologically plausible neuronal population model is developed which considers functional outcome of astrocyte-neuron interactions too. The employed structure is based on the physiological and anatomical network properties of the hippocampal CA1 area. Utilizing these two different levels of modeling, it is demonstrated that astrocytes are able to change the threshold value of transition from synchronous to asynchronous behavior among neurons. In this way, variations in the interaction between astrocytes and neurons lead to the emergence of synchronous/asynchronous patterns in neural responses. Furthermore, population spikes are recorded from CA1 pyramidal neurons in rat hippocampal slices to validate the modeling results. It demonstrates that astrocytes play a primary role in neuronal firing synchronicity and synaptic coordination. These results may offer a new insight into understanding the mechanism by which astrocytes contribute to stabilizing neural activities. 相似文献
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