On the Application of Fuzzy Decision Theory in Chemotherapy

1IntreductionTheliteratUreonmulti-Criteriondecisionmaking(MCDM)problemshas~tremendouslyintherecentpast.TwomajorareashaveevolvedwhiChbothconcentrateondecisionmakingwithseveralcriteria:multiobjectivedecisionmaking(MODM)andmulti-attributedecisionmaking(MADM).TheformerconcentratesoncontinuousdecisionspaceandthelatterfocusesonproblemswithdiscreteSPace.FuzzysettheoryhascontributedtoMODMproblemsaswellastheMADMProblems.ThegeneralMODMproblemcanbedeft.edLllasfollows:Twostagescangenerallybe…     

微藻生物技术新进展

微藻生物技术是较新的生物技术领域之一。藻的生物技术本质上与农业相同,即利用光合成机制生产生物量,用作食物、饲料、化学药品和能源。 培养微藻作生物量的主要优点为: 1.藻是很有效的生物系统,是以太阳能通过光合成生产有机化合物的。     

FT Ⅰ, a novel positive myeloid-lineage-specific transcription regulatory element within the mouse myeloperoxidase gene enhancer, En 1

INTanDUCTI0NMyeloidcelldifferentiati0n,inwhichmultip0tentialprogenitorcellsarec0nvertedint00neofthesixmaturedifferentiatedcells,i.e.,erythr0cytes,platelets(megakary-ocytes),macr0phages,neutr0phils,e0sinophilsandbas0phils,involvestemporalre-gulati0nofexpression0fanumberoflineage-anddifferentiationstage-specificgenes.Understandingthedevel0pmentalspecificationoflineageaJswellasmaturationstageassociatedpatterns0fgeneexpressioninmyel0idcelldifferentiationrequiresanin-sightintothecontrol0findivid…     

玫瑰茄光周期反应的研究

来源于泰国、中美洲、塞内加尔、印度和埃及的五个玫瑰茄品系,在光周期为8、16和24小时的人工气候室内生长。通过短日照和连续光照诱导开花证实,所有品系均为双光周期。各品系在花、果发育和由短日照转变到长日照后持续地成花诱导中显出差异。短日照和连续光照产生的生理效应和形态效应均不同。在每个叶腋的两个成对芽中,左芽在光周期为8和24小时成花,在光周期16小时保持休眠;右芽在8小时保持休眠,在16小时发育成营养枝,而在24小时发育成花枝。作者讨论了这些资料对亚热带条件下玫瑰茄育种和栽培的重要意义。     

肝硬化合并结核病患者的临床特征

目的分析肝硬化合并结核病患者的临床特征,为该类患者的治疗提供参考。方法回顾性分析2014年9月至2017年7月于浙江大学医学院附属第一医院住院的肝硬化合并结核病患者的相关资料,总结患者的临床特征。结果共收治68例肝硬化合并结核病患者,其中男性50例(73.5%),女性18例(26.5%),平均年龄(59.9±13.7)岁。在所有患者中,肝硬化最常见的原因是HBV感染(46例,67.7%)和酒精(9例,13.2%)。肺结核(43例)、结核性腹膜炎(13例)、结核性胸膜炎(12例)是最常见的结核类型,此外骨关节结核、结核性脑膜炎、结核性心包炎、泌尿系结核、肠结核、淋巴结结核均可见。该类患者常见临床表现为乏力、腹胀,出现发热的患者不足半数,有盗汗表现的更为罕见。结论肝硬化患者并发结核后可使病情复杂化,增加治疗难度。此外部分患者临床表现不典型,需提高警惕,避免漏诊。     

端粒长度及端粒酶活性与儿童先天性心脏病发病机制的相关性研究

目的:探讨不同年龄儿童外周血白细胞端粒长度及端粒酶活性与儿童先心病发病机制的相关性.方法:采用实时荧光定量PCR检测先天性心脏病2个年龄组及健康受试者外周血白细胞的端粒长度及hTERT mRNA(端粒酶催化亚基).比较相同年龄的先天性心脏病与健康受试者外周血白细胞的端粒长度及hTERT mRNA差异,并比较不同年龄组间外周血白细胞的端粒长度及hTERT mRNA差异.结果:先天性心脏组3-6岁组的受检者及健康受试者3-6岁组平均外周血白细胞端粒(1.63± 0.61)长于先天性心脏组7-10岁组的受检者及健康受试者7-10岁组(1.36± 0.46)(t=1 1.37,P＜0.05);各组均无端粒酶表达.结论:外周血白细胞的端粒长度随着年龄的增长而缩短.端粒酶活性与先天性心脏病发病并无直接相关性.     

Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif

Particular HLA class II allelic sequences are associated with susceptibility to type I diabetes. To understand the mechanism, knowledge of the molecular nature of the specific TCR/peptide/class II interactions involved in the disease process is required. To this end, we have introduced the diabetes-associated human class II HLA-DQ8 allele (DQA1*0301/DQB1*0302) as a transgene into mice and analyzed T cell responses restricted by this molecule to an important Ag in human diabetes, human glutamic acid decarboxylase 65. Hybridomas were used to determine the particular peptides from this Ag presented by HLA-DQ8 to T cells and to map the core minimal epitopes required for T cell stimulation. Analysis of these core epitopes reveals a motif and relevant features for peptides that are immunogenic to T cells when presented by HLA-DQ8. The major immunogenic epitopes of glutamic acid decarboxylase 65 do not contain a negatively charged residue that binds in the P9 pocket of the HLA-DQ8 molecule. PBMC from HLA-DQ8+ diabetic and nondiabetic individuals respond to these peptides, confirming that the mouse model is a useful tool to define epitopes of autoantigens that are processed by human APC and recognized by human T cells.     

Isolation and functional analysis of a Brassica juncea gene encoding a com-ponent of auxin efflux carrier

Polar auxin transport plays a divergent role in plant growth and developmental processes including root and embryo development, vascular pattern formation and cell elongation. Recently isolated Arabidopsis pin gene family was believed to encode a component of auxin efflux carrier (G(?)lweiler et al, 1998). Based on the Arabidopsis pin1 sequence we have isolated a Brassica juncea cDNA (designated Bjpin1), which encoded a 70-kDa putative auxin efflux carrier. Deduced BjPIN1 shared 65% identities at protein level with AtPINl and was highly homologous to other putative PIN proteins of Arabidopsis (with highest homology to AtPIN3). Hydrophobic analysis showed similar structures between BjPINl and AtPIN proteins. Presence of 6 exons (varying in size between 65 bp and 1229 bp) and 5 introns (sizes between 89 bp and 463 bp) in the genomic fragment was revealed by comparing the genomic and cDNA sequences. Northern blot analysis indicated that Bjpin1 was expressed in most of the tissues tested, with a relatively h