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71.
D P Tracer 《American journal of physical anthropology》1991,85(4):393-405
Evolutionary theory predicts that organisms make trade-offs between their somatic and reproductive energy budgets. Thus every round of reproduction should result in a concomitant decline in the parents' total energy reserves. Among humans this prediction was corroborated more than 25 years ago when fertility-related nutritional depletion was reported among mothers in the Highlands of New Guinea (Jelliffe and Maddocks, 1964). More recently, however, a number of studies of fertility and maternal nutritional status in both developed and developing nations have reported fertility-related increases in various indices of adiposity and lean body mass. Such findings have called the so-called "maternal depletion syndrome" into question, and have raised serious doubts as to whether the phenomenon is widely generalizable to all populations. In light of this recent controversy, data are presented here on fertility-related changes in maternal adiposity and lean body mass among the Au, a lowland forager-horticulturalist population in Papua New Guinea. While both a short-term decline in adiposity following childbirth, and a long-term fertility-related decline are seen among more traditional Au, individuals with a regular source of wage-income show only the former. There are no significant changes in lean body mass with increasing fertility in either group. The finding of significant socioeconomic variation in the capacity to withstand the stress of repeated reproduction even within this one extremely rural area of Papua New Guinea may lend insight into why previous studies have been unable to find evidence of maternal depletion. The fertility-related decline in adiposity that is reported for the more traditional Au is consistent with the predictions of evolutionary theory. 相似文献
72.
Lactating rats and their suckling offspring were shown to have a naturally occurring resistance to Trypansoma lewisi which was greater than that seen in normal adult rats and was not dependent on previous exposure to the parasite. In the case of the pups maximum protection was dependent on suckling being the sole source of nutriment and also on the peak of the parasitemia falling within the nursing period. Supplementary solid food reduced survival rates in concurrent Hemobartonella muris—T. lewisi infections: pups infected at 10 days of age and totally dependent on nursing showed 82.5% survival but only 6.6% survival when solid food was allowed to supplement milk. However, supplementary food did not reduce survival in pups infected with only T. lewisi. When pups were totally dependent upon nursing until the normal time of weaning (21 days of age), infection with H. muris—T. lewisi at the following days of age allowed the indicated mean survival rates: 10 days (82.5%), 20 (32.5%), 30 (14.3%), and 40 (100%). Infection with T. lewisi alone at the following days of age allowed the indicated mean survival rates: 10 days (100%), 15 (76%), 17 (52%), 20 (100%), and 30 (100%). Lactating rat serum agglutinated “adult forms” of T. lewisi, which correlated well with the observed sudden resolution of parasitemia in lactating animals at the time of the antigenic transition from “juvenile” to “adult” type. The “adult” stage parasitemia in suckling pups was selectively reduced when compared to that of nonlactating adult rats. The lactating rat serum factor could be passively transferred with lactating rat serum to animals already weaned. 相似文献
73.
Mammary involution after cessation of milk removal is associated with extensive loss of secretory epithelial cells. Ultrastructural changes and the appearance of oligonucleosomal DNA laddering in ethidium bromide-stained gels indicates that cell loss during involution occurs by apoptosis. In this study, a technique for nick end-labelling of genomic DNA with radiolabelled deoxynucleotide has been used to monitor the induction of programmed cell death in mice after litter removal at peak lactation. This technique proved more sensitive than conventional ethidium bromide staining, and results suggested that apoptosis was induced rapidly by milk stasis, before extensive tissue re-modelling had begun. Oligonucleosomal DNA laddering on agarose gels was detected within 24 h of milk stasis, and increased progressively for at least 4 days. Nick-end labelling also detected laddering before litter removal, suggesting that programmed cell death is a normal feature of the lactating tissue. The DNA end-labelling technique was also adapted for in situ visualisation of apoptotic cells in tissue sections. By this criterion, apoptotic cells were identified in both the secretory epithelium lining the alveoli of the gland and, increasingly with prolonged milk stasis, amongst those sloughed into the alveolar lumen. The results demonstrate the utility of these techniques for study of mammary cell death and suggest that, whilst apoptosis is rapidly induced by milk stasis, it is also a normal physiological event in the lactating mammary gland. 相似文献
74.
Eluned C. Price 《Primates; journal of primatology》1992,33(1):99-106
The energetic costs of reproduction are likely to be particularly high in the Callitrichidae (marmosets and tamarins), which
characteristically produce twin litters. The activity of five captive breeding pairs of cotton-top tamarins (Saguinus oedipus) was investigated for a 6-month period covering the second half of pregnancy and lactation. Breeding males showed few major
changes in activity over this period, but breeding females reduced their levels of locomotion during late pregnancy, and during
lactation they spent up to twice as much time feeding and foraging as they did during pregnancy. These results support the
hypothesis that the costs that callitrichid females incur when reproducing are likely to have been an important factor in
the evolution of these species' communal rearing systems. 相似文献
75.
Masaaki Hirose Masatoshi Maki Hideo Chiba 《Biochimica et Biophysica Acta (BBA)/General Subjects》1980,629(1):168-177
Experiments were carried out to identify progestin-binding receptors in the mammary gland where casein synthesis is known to be inhibited by this hormone. A progestin-binding component with high affinity, low capacity and a sedimentation coefficient of 8.8 S was isolated from the cytosol of lactating rat mammary glands. This component strongly bound [3H]R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione) with a dissociation constant of 3.9 · 10?9 M under low-salt conditions and with that of 8.2 · 10?10 M in the presence of 0.3 M KCl. Specificity studies showed a higher degree of progestin specificity under high salt conditions. In the absence of KCl, binding of [3H]-R5020 was inhibited by unlabeled glucocorticoid in the same degree as unlabeled progestin, but the inhibition by glucocorticoid was greatly diminished by the presence of 0.3 M KCl. These observations suggest that the [3H]R5020-binding-component is the progestin receptor and that its function may be regulated by the concentration of glucocorticoid and salt. 相似文献
76.
The impact of pregnancy and lactation on ultradian rhythms (URs) and circadian rhythms (CRs) of locomotor activity was assessed in circadian rhythmic and arrhythmic Siberian hamsters maintained in a long-day photoperiod (16 h light/day). Progressive decrements in CR robustness and amplitude over the course of gestation were accompanied by enhanced URs. Dark-phase UR period and amplitude increased during early gestation and complexity and robustness increased during late gestation. The persistence of pregnancy-associated enhancements of URs in circadian arrhythmic (ARR) hamsters suggests that reproductive modulation of the UR waveform is not dependent on coherent circadian organization. The increased incidence of dark-phase URs appeared more rapidly in ARR dams than entrained (ENTR) dams. Throughout gestation, the percentage of dams with dark-phase URs was significantly greater in the ARR group. Gestational increases in UR complexity and robustness emerged earlier and were greater in ARR than ENTR dams. The attenuation of CRs during lactation is correlated with increased expression of URs. Relaxation of circadian control of the dam's behavior may increase fitness by permitting more efficient interactions with circadian arrhythmic pups. 相似文献
77.
78.
The objective of this study was to evaluate the effects of a novel oxygen-coordinated niacin-bound chromium(III) complex (NBC) on the reproductive systems of male and female rats, the postnatal maturation and reproductive capacity of their offspring, and possible cumulative effects through multiple generations. Sprague-Dawley rats were maintained on feed containing NBC at dose levels of 0, 4, 15, or 60 ppm for 10 weeks prior to mating, during mating, and, for females through gestation and lactation, across two generations. For the parents (F0 and F1) and the offspring (F1 and F2a), reproductive parameters such as fertility and mating, gestation, parturition, litters, lactation, sexual maturity and development of offspring were assessed. Results from the current study indicated that dietary exposure of NBC to parental male and female rats of both (F0 and F1) the generations during the premating and mating periods, for both sexes, and during gestation and lactation in case of female rats, did not cause any significant incidence of mortality or abnormal clinical signs. Compared to respective controls, NBC exposure did not affect reproductive performance as evaluated by sexual maturity, fertility and mating, gestation, parturition, litter properties, lactation and development of the offspring. Based on the findings of this study, the parental as well as the offspring no-observed-adverse-effect level for NBC was determined to be greater than 60 ppm in diet or equivalent to 7.80 and 8.31 mg/kg body weight/day in male and female rats, respectively. 相似文献
79.
《Archives of animal nutrition》2013,67(1):17-24
Two groups of 26 male and 26 female rats at the initial age 30 ± 2 days were fed during 31 weeks on diets containing 20 percent of yellow lupin seeds having low (LG) or high (HG) gramine content. The animals were mated twice within nutritional groups, 1 male: 1 female, and their main reproductive parameters were recorded. In both reproductive cycles body weight of females at mating, after parturition and after 21‐days lactation was lower in HG than in LG group. Fertility rate and body weight of neonates were not affected by the diet while number of neonates per litter tended to be lower by 0.7 and 0.8 pups in HG than in LG group. Body weight of weaners was also substantially smaller in dams fed on HG than LG diet. Relative weight of spleen but not of liver, kidney and heart was significantly greater in HG females. Four weeks old males and females issued from the first litters born to LG and HG animals (ten males and ten females per treatment) were fed individually on respective diets during 3 weeks. Feed intake and growth rate did not differ between the treatments. In males relative weight of liver and testicles was greater, while hematocrit and red blood count were lower in HG than in LG group. In females organ weights did not differ. Activity of liver enzymes determined in males was not affected by the diet. It may be concluded that high‐gramine lupin affects negatively lactational performance, probably via lower feed intake, but it does not induce apparent teratogenic effects in the progeny. 相似文献
80.
Palou M Torrens JM Priego T Sánchez J Palou A Picó C 《The Journal of nutritional biochemistry》2011,22(6):574-584
We aimed to assess the lasting effects of moderate caloric restriction in lactating rats on the expression of key genes involved in energy balance of their adult offspring (CR) and their adaptations under high-fat (HF) diet. Dams were fed with either ad libitum normal-fat (NF) diet or a 30% caloric restricted diet throughout lactation. After weaning, the offspring were fed with NF diet until the age of 15 weeks and then with an NF or a HF diet until the age of 28 weeks, when they were sacrificed. Body weight and food intake were followed. Blood parameters and the expression of selected genes in hypothalamus and white adipose tissue (WAT) were analysed. CR ate fewer calories and showed lower body weight gain under HF diet than their controls. CR males were also resistant to the increase of insulin and leptin occurring in their controls under HF diet, and HF diet exposed CR females showed lower circulating fasting triglyceride levels than controls. In the hypothalamus, CR males had higher ObRb mRNA levels than controls, and CR females displayed greater InsR mRNA levels than controls and decreased neuropeptide Y mRNA levels when exposed to HF diet. CR males maintained WAT capacity of fat uptake and storage and of fatty-acid oxidation under HF diet, whereas these capacities were impaired in controls; female CR showed higher WAT ObRb mRNA levels than controls. These results suggest that 30% caloric restriction in lactating dams ameliorates diet-induced obesity in their offspring by enhancing their sensitivity to insulin and leptin signaling, but in a gender-dependent manner. 相似文献