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11.
12.
Gunilla Hjelmquist Jill Andersson Bror Edlund Lorentz Engström 《Biochemical and biophysical research communications》1974,61(2):559-563
Pig liver pyruvate kinase (type L) was 32P-labelled by incubation with (32P)ATP and cyclic 3′,5′-AMP-stimulated protein kinase from the same source. One major (32P)phosphopeptide was isolated from a peptic hydrolysate of the enzyme. Its amino acid sequence was Leu-Arg-Arg-Ala-(32P)SerP-Leu. 相似文献
13.
Adenosine and adenosine analogues inhibited electrically evoked 3H-noradrenaline (3H-NA) release from slices of the rat hippocampus in vitro in a dose -dependent manner in the concentration range 0.01–100 M. L-phenylisopropyladenosine (L-PIA) was more potent than 5′-N-carboxamidoadenosine (NECA), which was more potent than adenosine. The adenosine uptake blocker dipyridamole (3 M) enhanced the effect of exogenous adenosine, and had a slight inhibitory effect per se. The effect of L-PIA on NA release was competitively antagonized by 8-phenyltheopylline; pA2=7.1. Enprophylline (300 M), theophylline (300 M) and 8-phenyltheophylline (1–10 M) enhanced the evoked 3H-NA release per se, while no such enhancement was seen with the non-xanthine phosphodiesterase inhibitor ZK 62.711 (Rolipram) (30 M).It is concluded that adenosine, at physiologically relevant concentrations, inhibits electrically evoked NA release from terminals in the central nervous system. Alkylxanthines increase evoked NA release from hippocampal terminals, wich probably not related to cyclic AMP but may partly involve inhibition of endogenous adenosine acting as a modulator of transmitter release in the hippocampal slice preparation. 相似文献
14.
Odd Terje Sandlund Hilmar J. Malmquist Bror Jonsson Skúli Skúlason Sigurdur S. Snorrason Pétur M. Jónasson Rolf Gydemo Torfinn Lindem 《Environmental Biology of Fishes》1988,23(3):183-195
Synopsis Population densities of age-0 arctic chaff in the surf zone averaged 1.83 and 4.70 fish m-2 in August 1984 and June 1985, respectively. Length variation of the littoral fish was low in early summer, increasing in
late summer and autumn. Newly emerged charr, ∼ 20 mm long, appeared in the stony shallow water zone during both May and June.
From length variation and variation in mouth position of the young charr, it is concluded that at least two of the four chaff
morphs in the lake are present in the surf zone during spring and summer. In August, some of the larger age-0 charr had moved
out from the surf zone, into the pelagic and the deeper epibenthic waters. The food of young littoral charr was dominated
by large chironomid larvae (instar 3 and 4) and pupae
Contribution from the Thingvallavatn project 相似文献
15.
Bror Edlund Örjan Zetterqvist Ulf Ragnarsson Lorentz Engström 《Biochemical and biophysical research communications》1977,79(1):139-144
Cyclic GMP-stimulated protein kinase from pig lung has been shown to phosphorylate synthetic peptides. The rate of phosphorylation was about one order of magnitude higher than that for mixed histones at a comparable concentration, 0.1 mM. The peptides represented sites, phosphorylatable by cyclic AMP-stimulated protein kinase, in pyruvate kinase type L from rat liver, calf thymus histone H2B and the α-subunit of rabbit muscle phosphorylase b kinase. The shortest pyruvate kinase peptide that could be phosphorylated at a significant rate by cyclic GMP-stimulated protein kinase was Arg-Arg-Ala-Ser-Val-Ala, which is one amino acid residue longer than the minimal substrate of cyclic AMP-stimulated protein kinase. The apparent Km was 0.3 mM which is about 10 times higher than that with cyclic AMP-stimulated protein kinase. The Km was only slightly decreased upon successive extension of the peptide in the N-terminal direction to Gly-Val-Leu-Arg-Arg-Ala-Ser-Val-Ala. Modification of the sequence showed the importance of two adjacent arginyl residues, and substitution of arginine for the C-terminal alanine abolished the measurable activity. Thus, it has been demonstrated that there are both differences and similarities in substrate specificity of the two protein kinases. 相似文献
16.
Changes in use of lake habitat by experimentally segregated populations of cutthroat trout and Dolly Varden char 总被引:1,自引:0,他引:1
Joyce H. Andrew Nina Jonsson Bror Jonsson Kjetil Hindar Thomas G. Northcote 《Ecography》1992,15(2):245-252
The role of competition in a lacustrine community of two salmonid species, cutthroat trout Oncorhynchus clarki and Dolly Varden char Salvelinus malma , was studied in three coastal British Columbia lakes Habitat use by the species alone (allopatric) and in coexistence with each other (sympatric) was investigated by gill netting at 0-40 m depth contours (surface to bottom) so that several habitats (littoral, epipelagic. pelagic, epibenthic) were sampled From June to October, trout used mainly littoral and epipelagic habitats in sympatry and allopatry Char used all habitats in allopatry. and deep habitats (pelagic, epibenthic) not frequented by trout in sympatry The two species were thus spatially segregated with depth in sympatry Diel (day, night) and seasonal changes (spring, summer, autumn) in habitat use were not pronounced The shift in habitat use by experimentally allopatric char but not trout suggests that the effects of competition between sympatric trout and char for habitat resources are greater on the char 相似文献
17.
Hu KF Regner M Siegrist CA Lambert P Chen M Bengtsson KL Morein B 《FEMS immunology and medical microbiology》2005,43(2):269-276
A successful vaccine against human RSV (HRSV) is likely to induce a Th1 or a balanced Th1/TH2 cytokine response. We tested a panel of HRSV immunostimulating complexes (ISCOMs) containing different Quillaja saponin fractions (QH-A, QH-C, and 703: a mixture of 70% QH-A and 30% QH-C) with different immunological properties for their capacity of inducing innate and acquired immune responses. The HRSV 703 ISCOMs induced the strongest innate and acquired immune responses, followed by RSV QH-C and QH-A ISCOMs. All three formulations induced various degrees of Th1 bias response with prominent production of IFN-gamma being 10-50 times higher than that of IL-4 and IL-5. The HRSV specific IgG isotype profile correlated with the predominant secretion of Th1 cytokines, with strong induction of IgG2a antibodies. The 703 ISCOMs induced the most pronounced Th1 profile followed by QH-C and QH-A ISCOMs. The high incorporation of F protein in these ISCOMs compared to G protein combined with the Th1 biased nature of ISCOM are likely to be the causes to promote a Th1 type of profile. The prospect to formulate an RSV ISCOM formulation with an optimal Th1/Th2 balance is in reach particularly in view of the versatile properties of the ISCOM concept. 相似文献
18.
Næsje Tor Fredrik Sandlund Odd Terje Jonsson Bror 《Environmental Biology of Fishes》1986,17(4):309-314
Synopsis Local American eel stocks were studied by mark-recapture methods along 600m of tidal creeks in Great Sippewisset Marsh, Falmouth, Massachusetts, during summer 1979. The estimated stock density was 350 eels, equivalent to 875 fish ha-1, and movement of individual American eels over the five week study was usually less than 100 m. Large American eels were found to predominate in the wide marsh creeks whereas smaller American eels predominated in narrower creeks at the landward side of the marsh. Territoriality is suggested as a mechanism for maintaining differences in distribution of size classes and a limited home range.Senior author 相似文献
19.
Jaime Otero Jan Henning L'Abée‐Lund Ted Castro‐Santos Kjell Leonardsson Geir O. Storvik Bror Jonsson Brian Dempson Ian C. Russell Arne J. Jensen Jean‐Luc Baglinière Mélanie Dionne John D. Armstrong Atso Romakkaniemi Benjamin H. Letcher John F. Kocik Jaakko Erkinaro Russell Poole Ger Rogan Hans Lundqvist Julian C. MacLean Erkki Jokikokko Jo Vegar Arnekleiv Richard J. Kennedy Eero Niemelä Pablo Caballero Paul A. Music Thorolfur Antonsson Sigurdur Gudjonsson Alexey E. Veselov Anders Lamberg Steve Groom Benjamin H. Taylor Malcolm Taberner Mary Dillane Fridthjofur Arnason Gregg Horton Nils A. Hvidsten Ingi R. Jonsson Nina Jonsson Simon McKelvey Tor F. Næsje Øystein Skaala Gordon W. Smith Harald Sægrov Nils C. Stenseth Leif Asbjørn Vøllestad 《Global Change Biology》2014,20(1):61-75
Migrations between different habitats are key events in the lives of many organisms. Such movements involve annually recurring travel over long distances usually triggered by seasonal changes in the environment. Often, the migration is associated with travel to or from reproduction areas to regions of growth. Young anadromous Atlantic salmon (Salmo salar) emigrate from freshwater nursery areas during spring and early summer to feed and grow in the North Atlantic Ocean. The transition from the freshwater (‘parr’) stage to the migratory stage where they descend streams and enter salt water (‘smolt’) is characterized by morphological, physiological and behavioural changes where the timing of this parr‐smolt transition is cued by photoperiod and water temperature. Environmental conditions in the freshwater habitat control the downstream migration and contribute to within‐ and among‐river variation in migratory timing. Moreover, the timing of the freshwater emigration has likely evolved to meet environmental conditions in the ocean as these affect growth and survival of the post‐smolts. Using generalized additive mixed‐effects modelling, we analysed spatio‐temporal variations in the dates of downstream smolt migration in 67 rivers throughout the North Atlantic during the last five decades and found that migrations were earlier in populations in the east than the west. After accounting for this spatial effect, the initiation of the downstream migration among rivers was positively associated with freshwater temperatures, up to about 10 °C and levelling off at higher values, and with sea‐surface temperatures. Earlier migration occurred when river discharge levels were low but increasing. On average, the initiation of the smolt seaward migration has occurred 2.5 days earlier per decade throughout the basin of the North Atlantic. This shift in phenology matches changes in air, river, and ocean temperatures, suggesting that Atlantic salmon emigration is responding to the current global climate changes. 相似文献
20.
Valerie Querol-ferrer Bror Jonzon Anna Hultgårdh-Nilsson 《Nucleosides, nucleotides & nucleic acids》2013,32(5):1155-1159
Abstract In aortic smooth muscle cell cultures of adult and newborn rats, the NECA-induced CAMP accumulation was enhanced in adults. The inhibitory effect of the A,-receptor is unlikely to be the main factor responsible for this large difference. 相似文献