On‐the‐fly detection of changes on and below the surface in epithelium mucosal tissue architecture from scattered light

In this paper we present a technique to raise a flag on the fly when a transition occurs between different mucosal architectures on or below the surface. The segmentation is based on a novel difference metric for detecting an abrupt change in the parameters extracted from a Stochastic Decomposition Method (SDM) that models the scattered light reflected from the mucosal tissue structure over an area (2‐D scan) illuminated by an optical sensor (fiber) emitting light at either one wavelength or with white light. This work has the potential to enhance the endoscopist's ability to locate and identify abnormal mucosal architectures in particular when the disease is developing below the surface and hence becoming hidden during colonoscopy or endoscopic examination. It also has also potential in helping deciding as to when and where to take biopsies; steps that should lead to improvement in the diagnostic yield. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)     

我国公立医院结构布局优化的路径及思考?????? ——基于17个试点城市的经验

随着公立医院改革试点指导意见的出台，探索公立医院结构和布局优化成为公立医院管理体制改革的主要任务。文章总结了17个新医改试点城市优化医疗机构布局改革方案的异同，进行分析与探讨并得出相关启示，旨在为我国更好地推进公立医院改革提供借鉴。     

广东医调委运行机制及其完善策略探讨

广东医调委经过近5年的探索与实践，开创了运用市场机制解决社会问题的新局面，并在过往调解实践和经验的基础上，创新和完善出一套有效解决医患纠纷的“保、调、赔、防、管”联合机制，对构建和谐医患关系和防范医疗风险具有积极的借鉴意义。     

Easter Art Feast

The purpose of this report is to provide insight into how state departments are implementing legislative requirements for educator evaluation, particularly the specific circumstances states encounter around arts education. Spotlights on Delaware, a first-round recipient of Race to the Top funding, and Colorado and Arizona, third-round recipients, provide a variety of state-level approaches. Not only do the state contexts differ because of funding variability and level of focus on arts education, size and state laws around local control also play a factor in how states are able to implement educator evaluation requirements. To add to the complexity of this implementation, educator evaluation is a component within several education reforms in all disciplines, including new standards adoption, student assessment development and/or implementation, and need for professional development for arts educators. These multiple components play important roles in state efforts to meet educator evaluation requirements for arts educators. This report outlines each state context and other reform elements at play, and shares opportunities and challenges within the educational landscape. This report does not advocate for, speculate on, or share opinions about these efforts, as the primary role of state departments is to oversee, manage, and support schools and districts in any change process required by state and/or federal law.     

Real‐time video mosaicking to guide handheld in vivo microscopy

Handheld and endoscopic optical‐sectioning microscopes are being developed for noninvasive screening and intraoperative consultation. Imaging a large extent of tissue is often desired, but miniature in vivo microscopes tend to suffer from limited fields of view. To extend the imaging field during clinical use, we have developed a real‐time video mosaicking method, which allows users to efficiently survey larger areas of tissue. Here, we modified a previous post‐processing mosaicking method so that real‐time mosaicking is possible at >30 frames/second when using a device that outputs images that are 400 × 400 pixels in size. Unlike other real‐time mosaicking methods, our strategy can accommodate image rotations and deformations that often occur during clinical use of a handheld microscope. We perform a feasibility study to demonstrate that the use of real‐time mosaicking is necessary to enable efficient sampling of a desired imaging field when using a handheld dual‐axis confocal microscope.     

Automated thermal imaging monitors the local response to cervical cancer brachytherapy

Malignant tumors have high metabolic and perfusion rates, which result in a unique temperature distribution as compared to healthy tissues. Here, we sought to characterize the thermal response of the cervix following brachytherapy in women with advanced cervical carcinoma. Six patients underwent imaging with a thermal camera before a brachytherapy treatment session and after a 7-day follow-up period. A designated algorithm was used to calculate and store the texture parameters of the examined tissues across all time points. We used supervised machine learning classification methods (K Nearest Neighbors and Support Vector Machine) and unsupervised machine learning classification (K-means). Our algorithms demonstrated a 100% detection rate for physiological changes in cervical tumors before and after brachytherapy. Thus, we showed that thermal imaging combined with advanced feature extraction could potentially be used to detect tissue-specific changes in the cervix in response to local brachytherapy for cervical cancer.     

医学生科研创新能力培养“3+X”模式的探索与实践

针对长期以来培养医学生的科研创新能力主要依靠零散的课外科研活动、受众面窄、没有系统性课程教学及其相关制度保障、致使对医学生科研创新能力培养明显乏力低效这一共性瓶颈教学问题,自2002年起,汕头大学医学院生物化学与分子生物学教学团队,在“科教相辅相佐”、“以学生为中心”、“以问题为导向”等先进教育理念指导下,倚重汕头大学医学院“医者之心”系列课程与书院育人文化之特色,发挥汕头大学的生物学、基础医学和临床医学一级学科均拥有本/硕/博/博后完整人才培养体系之优势,联合其他相关专业教学团队,在建立充分体现医学生科研创新能力培养内涵,覆盖医学本科5年全过程的核心课程体系的基础之上,历经20载的不懈努力,补充修善,成功构建了“3+X”模式,着力培养医学生的科研创新能力。所谓“3”意指对医学生的“全人培养”、“全程培养”和“全方位培养”。所谓“X”意指针对“3+X”模式运行效能的若干个验证性维度,主要包括组织医学生参加各种形式的全国大学生创新实验研究大赛、国际大学生学术研讨会,由医学本科生作为第一作者撰写发表学术论文等。培养医学生科研创新能力的成效十分显著,为有效解决上述共性瓶颈教学问题提供了一个有重要借鉴价值的范例。