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排序方式: 共有182条查询结果,搜索用时 328 毫秒
21.
Mandy L. H. Cook René A. Varela Juli D. Goldstein Stephen D. McCulloch Gregory D. Bossart James J. Finneran Dorian Houser David A. Mann 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2006,192(5):489-495
Several mass strandings of beaked whales have recently been correlated with military exercises involving mid-frequency sonar highlighting unknowns regarding hearing sensitivity in these species. We report the hearing abilities of a stranded juvenile beaked whale (Mesoplodon europaeus) measured with auditory evoked potentials. The beaked whale’s modulation rate transfer function (MRTF) measured with a 40-kHz carrier showed responses up to an 1,800 Hz amplitude modulation (AM) rate. The MRTF was strongest at the 1,000 and 1,200 Hz AM rates. The envelope following response (EFR) input–output functions were non-linear. The beaked whale was most sensitive to high frequency signals between 40 and 80 kHz, but produced smaller evoked potentials to 5 kHz, the lowest frequency tested. The beaked whale hearing range and sensitivity are similar to other odontocetes that have been measured. 相似文献
22.
Zu-Lin Yu Qiang Qiu Zhi-Min Xu Jun-Xian Shen 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2006,192(8):801-806
The piebald odorous frog (Odorrana schmackeri), the large odorous frog (Odorrana livida) and the concave-eared torrent frog (Amolops tormotus) are sympatric species living near the same torrent streams in the vicinity of Mt. Huangshan, China. A recent study demonstrated that A. tormotus can use sound signals involving ultrasonic components for communication in a noisy environment, and another sympatric species, O. livida, can also perceive ultrasonic sound. Here we report data on the hearing range of O. schmackeri by studying auditory evoked potentials and single-unit data from the torus semicircularis. This frog exhibits its two most sensitive peaks at 2 kHz and 3.5–4.0 kHz with thresholds <42 dB SPL, with an upper frequency limit of hearing at 8.5 kHz with threshold of 87 dB SPL. The upper limit is much lower than those of O. livida and A. tormotus, at 22 and 34 kHz, respectively. It suggests that sympatric species may respond differently to similar environmental selection pressures sculpting auditory communication systems. 相似文献
23.
Xing G Chen Z Wei Q Tian H Li X Zhou A Bu X Cao X 《Biochemical and biophysical research communications》2006,346(4):1131-1135
We have analyzed the clinical and molecular characterization of a Chinese family with aminoglycoside-induced and non-syndromic hearing impairment. Clinical evaluations revealed that only those family members who had a history of exposure to aminoglycoside antibiotics subsequently developed hearing loss, suggesting mitochondrial genome involvement. Sequence analysis of the mitochondrial 12S rRNA and tRNA(Ser(UCN)) genes led to the identification of a homoplasmic A827G mutation in all maternal relatives, a mutation that was identified previously in a few sporadic patients and in another Chinese family with non-syndromic deafness. The pathogenicity of the A827G mutation is strongly supported by the occurrence of the same mutation in two independent families and several genetically unrelated subjects. The A827G mutation is located at the A-site of the mitochondrial 12S rRNA gene which is highly conserved in mammals. It is possible that the alteration of the tertiary or quaternary structure of this rRNA by the A827G mutation may lead to mitochondrial dysfunction, thereby playing a role in the pathogenesis of hearing loss and aminoglycoside hypersensitivity. However, incomplete penetrance of hearing impairment indicates that the A827G mutation itself is not sufficient to produce clinical phenotype but requires the involvement of modifier factors for the phenotypic expression. Indeed, aminoglycosides may contribute to the phenotypic manifestation of the A827G mutation in this family. In contrast with the congenital or early-onset hearing impairment in another Chinese family carrying the A827G mutation, three patients in this pedigree developed hearing loss only after use of aminoglycosides. This discrepancy likely reflects the difference of genetic backgrounds, either mitochondrial haplotypes or nuclear modifier genes, between two families. 相似文献
24.
It has been postulated that the excellent sense of hearing in moose is mostly due to: (1) the large surface of the external
ear, (2) better stereophony due to the large distance between ears, (3) independently movable, extremely adjustable pinna,
and (4) the amplification of sounds reflected by the palms of the antlers. The last factor, possible reflection of sounds
into pinna by the palm of the antlers, was tested in this study on a large antler trophy of Alaskan moose. The reception of
a standard tone, broadcast from the frontally placed speaker, was recorded by a sound level meter located in an artificial
moose ear. Three locations of the ear, as positioned relative to the speaker, e.g., frontward, sideward, and backward, were
tested. The weakest reception was recorded in the backward position of the ear. If the sound pressure measured in the frontward
position was set as 100%, the sound pressure in the backward position was 79%. The strongest reception was recorded when the
artificial ear was positioned toward the center of the antler palm. In this position, the sound pressure was 119% relative
to the frontward position. These findings strongly indicate that the palm of moose antlers may serve as an effective, parabolic
reflector which increases the acoustic pressure of the incoming sound. 相似文献
25.
Abidi O Boulouiz R Nahili H Imken L Rouba H Chafik A Barakat A 《Biochemical and biophysical research communications》2008,377(3):971-974
In Caucasian populations a single mutation, 35delG, accounts for the majority of GJB2 gene mediated hearing loss, with carrier frequencies estimated between 2-4%, possibly resulting from a founder effect rather than from a mutational hot spot. In Moroccan population, the 35delG mutation accounts for 90.8% of all GJB2 mutated alleles in deaf patients with a carrier frequency of 2.65%. The aim of this study was to evaluate whether the 35delG mutation has derived from a single origin in the Moroccan population. We enrolled 30 unrelated deaf patients homozygous for the 35delG mutation and 165 unrelated control individuals negative for this mutation, and genotyped three microsatellite markers flanking the GJB2 region: D13S141, D13S175 and D13S143. Data analysis revealed that the 35delG mutation is associated with particular alleles of these markers, with significant linkage disequilibrium for the 125 and 105 nucleotide long alleles of D13S141 and D13S175, and that a single specific haplotype accounts for 68% of the chromosomes carrying the 35delG mutation. The estimate age of 35delG mutation is 135 generations or approximately 2700 years old. Like in other Mediterranean populations, our results suggest that in the Moroccan population the 35delG mutation has derived from a single origin in a common founder process. 相似文献
26.
Dai D Lu Y Chen Z Wei Q Cao X Xing G 《Biochemical and biophysical research communications》2008,377(4):1152-1155
We reported here the clinical and molecular characterization of a Chinese subject with childhood-onset hearing impairment. Clinical evaluations showed that the patient suffered from profound and non-syndromic sensorineural hearing loss with flat configurations. Sequence analysis of the mitochondrial 12S rRNA and tRNASer(UCN) genes led to the identification of double deafness-associated mutations of A1555G and T1095C in the 12S rRNA gene which apparently in the homoplasmic forms. In additional, there was no other functionally significant nucleotide variants found in this subject. As previous studies have indicated that the A1555G mutation was a primary contributing factor underlying the development of deafness but not sufficient to produce clinical phenotype, the co-segregation of two mitochondrial DNA mutations raises the possibility that the T to C transition at position 1095 plays a role in the phenotypic expression of deafness-associated A1555G mutation. Actually, the T1095C mutation disrupted an evolutionarily conserved base-pair at stem-loop of helix 25 of 12S rRNA, resulting in impaired translation in mitochondrial protein synthesis and a significant reduction of cytochrome c oxidase activity. As a result, it may enhance the biochemical defect in patient carrying the A1555G mutation, thus changing the age of onset and the severity of hearing impairment. 相似文献
27.
A.C. Gonçalves T.D. Matos H.R. Simões-Teixeira M. Pimenta Machado M. Simão Ó.P. Dias M. Andrea G. Fialho H. Caria 《Gene》2014
Low-frequency sensorineural hearing loss (LFSNHL) is an unusual type of HL in which frequencies at 2000 Hz and below are predominantly affected. Most of the families with LFSNHL carry missense mutations in WFS1 gene, coding for wolframin. 相似文献
28.
29.
G. Brückmann H. Burda 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1997,181(1):83-88
Thresholds for pure tone detection were examined in the common mole-rat, Cryptomys sp. (Bathyergidae, Rodentia) using a positive reinforcement procedure. To bypass the problems connected with testing isolated
individuals of this extremely social species, a collective behavioural audiogram was determined for a family group of seven
mole-rats. Within the tested frequency range of 225 to 18 kHz, the lowest thresholds (as low as 7.5 dB SPL, on average 24
dB SPL) were found at 800 Hz, the upper limit of hearing (at the level of 60 dB SPL) was at 18 kHz. The behavioural audiogram
combines the results of previous studies on hearing in this species. It resembles the distortion threshold curve but differs
from neurophysiological data as far as the high frequency cutoff is concerned. On the other hand, the region of the best hearing
sensitivity is narrow in behavioural audiogram and neurophysiological curves but rather broad in the distortion threshold
curve. In general, the behavioural audiogram of Cryptomys is in many aspects comparable with the available audiograms of other subterranean rodents.
Accepted: 18 February 1997 相似文献
30.
M. B. Jørgensen M. Kanneworff 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1997,182(1):59-64
The anuran middle ear serves to transmit eardrum vibrations to the inner ear. In order to do this efficiently, the eardrum
and middle ear must operate as an impedance transformer matching the low impedance of air to the higher impedance of the fluid-filled
inner ear. In amniotes, one of the mechanisms used to achieve impedance transformation is to have the middle ear work as a
force-amplifying lever system. Here, we present evidence that the grass frog middle ear also implements a lever system. The
columellar footplate, which sits in the oval window, is firmly connected to the otic capsule along its ventral edge. Therefore,
simple in-out movement of the columella is prevented while a rotational movement around the footplate's ventral edge is possible.
The latter movement pattern was confirmed by laser vibrometry measurements of eardrum and footplate vibrations. The results
showed that the footplate vibrations were 20–30 dB weaker than those of the eardrum and that the two structures vibrated 180°
out of phase (at low frequencies). The lever ratio was approximately 6, i.e. somewhat higher than lever ratios reported for
amniotes. Hence, the middle ear lever probably makes a significant contribution to impedance matching in frogs.
Accepted: 1 July 1997 相似文献