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核转录因子红细胞系2-p45相关因子2(nuclear factor-erythroid 2-p45 related factor 2,Nrf2)是调控细胞氧化还原稳态的重要转录因子。除了调节氧化应激反应外,近年来,Nrf2在代谢调节中的重要作用也备受关注。文章重点综述了Nrf2调控细胞的糖代谢、脂代谢、核酸代谢和氨基酸代谢的方式,并论述了Nrf2失调导致的多种代谢相关疾病,包括糖尿病、脂肪肝、帕金森氏症和肿瘤。最后,讨论了代谢压力介导的Nrf2活性改变与长寿、肿瘤防治及压力应激的关系。 相似文献
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Long-term endurance training or physical activity has been confirmed not only to improve physical performance, but to bring about an obvious beneficial effect on human health; however, the mechanism of this effect is not clear. The most studied health adaptations in skeletal muscle response to endurance exercise are increased muscle glycogen level and insulin sensitivity, fiber type transformation toward oxi- dative myofibers, and increased mitochondrial content/function. Mitochondria are dynamic organelles in eukaryotic cells critical in physical performance and disease occurrence. The mitochondrial life cycle spans biogenesis, maintenance, and clearance. Exercise training may promote each of these processes and confer positive impacts on skeletal muscle contractile and metabolic functions. This review focused on the regula- tion of these processes by endurance exercise and discussed its potential benefits in health and disease. We presented evidence suggesting that exercise training potentiates not only the biogenesis of mitochondria but also the removal of old and unhealthy mitochondria through mitochondrial quality control. 相似文献
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Raf激酶抑制蛋白(RKIP)是磷脂酰乙醇胺结合蛋白家族的成员。RKIP通过与Raf-1结合,抑制了Ras/Raf-1/MEK/ERK信号转导通路,并在NF-κB及G蛋白偶联受体(GPCR)信号转导通路中也起重要调节作用。RKIP参与细胞凋亡、肿瘤转移、神经发育以及精子发生等病理生理过程,通过研究RKIP能为治疗相关疾病提供新思路新靶点。本文主要介绍RKIP的生物功能,着重于其在神经系统、肿瘤和生殖系统中的研究进展。 相似文献
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Ding-Bang Hu Bing-Qing Luo Jie Li Yu Han Ting-Ru Jiang Jia Liu Gang Wu Hong-Xia Hua Yan-Fei Xiong Jun-Sheng Li 《Entomologia Sinica》2013,(6):703-716
The brown planthopper (BPH) Nilaparvata lugens is an economically impor- tant pest on rice plants. In this study, the higher population density and yellow-ripe stage of rice plants were used to construct adverse survival conditions (ASC) against BPH nymphs. Simultaneously, the low population density and tillering stage of rice plants were used to establish a suitable survival condition (SSC) as a control. Solexa/Illumina sequencing was used to identify genes of BPH nymphs responding to ASC. Significantly longer duration development of BPH nymphs and significantly lower brachypterous ratio of BPH adults were observed by ASC compared with SSC. A total of 2 544 differentially expressed genes (DEGs) were obtained and analyzed by BLASTx, Gene Ontology and KEGG Orthology. Gene ontology analysis revealed that the DEGs were mainly involved in categories of cell, cell part, cellular process, binding, catalytic, organelle and metabolic processes. 1138 DEGs having enzyme commission numbers were assigned to different metabolic pathways. The largest clusters were neurodegenerative diseases (137, 12.0%), followed by carbohy- drate metabolism (113, 9.9%), amino acid metabolism (94, 8.3%), nucleotide metabolism (76, 6.7%), energy metabolism (64, 5.6%), translation (60, 5.3%), lipid metabolism (58, 5.1%), and folding, sorting and degradation (52, 4.6%). Expressing profile of 11 DEGs during eight nymphal developmental stages of BPH were analyzed by quantitative real- time polymerase chain reaction. The 11 genes exhibited differential expression between ASC and SSC during at least one developmental stage. The DEGs identified in this study provide molecular proof of how BPH reconfigures its gene expression profile to adapt to overcrowding and low-quality hosts. 相似文献
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【摘 要】 目的 为了解血清1,3-β-D葡聚糖在呼吸科肺部真菌感染患者的检测水平,探究血清1,3-β-D葡聚糖对肺部真菌感染患者的诊断及治疗监测的效果。方法 对2011年至2013年东阳市横店集团医院的呼吸科就诊的50例肺部真菌感染患者作为实验组,而以30例非真菌的肺部感染患者及30例健康人群作为对照组,分析三组人群血清1,3-β-D葡聚糖的检测水平,同时对实验组中真菌半定量检测结果与血清1,3-β-D葡聚糖比较分析。结果 试验组血清1,3-β-D葡聚糖明显高于两组对照组(P<0.01),而非真菌的肺部感染组与健康人群组之间差异无统计学意义(P>0.05); 针对肺部真菌感染组的分析,发现痰液中真菌半定量培养阳性程度与患者血清1,3-β-D葡聚糖的水平呈现出正相关,痰液真菌培养半定量3+组血清1,3-β-D葡聚糖水平显著高于1+组和2+组(P<0.01)。结论 呼吸科肺部真菌感染患者血清1,3-β-D葡聚糖水平明显增高,且与痰液真菌培养阳性程度正相关,可作为临床肺部真菌感染诊断及疗效监测的指标之一。 相似文献