排序方式: 共有345条查询结果,搜索用时 15 毫秒
101.
Longying Wen Tuo Chen Manxiao Zhang Yong Wang Youfu Zhang Zhenghu Duan Lizhe An Qiliang Jian Renqing Peng 《Acta Physiologiae Plantarum》2010,32(4):801-808
Qilian Juniper (Sabina przewalskii Kom.) and Chinese juniper [Sabina chinensis (Lin.) Ant.] are overwintering plants. S. przewalskii, a protected species in China, is distributed in subalpine and alpine area on the Qinghai-Tibet Plateau. S. chinensis is distributed in plain area. We investigated seasonal changes in photoprotective stress compounds such as anthocyanins,
activities of three enzymes of ascorbate–glutathione pathway, as well as xanthophyll size and conversion in these species.
Ascorbate peroxidase (APX), dehydroascorbate reductase (DHAR) and glutathione reductase (GR) levels were higher in the low-temperature
months, which was associated with changes in anthocyanins and in de-epoxidation index [(A + Z)/(V + A + Z)]. Photochemical efficiency of PSII (Fv/Fm) was lower (<0.70) during winter and late autumn in both species. During the low-temperature
months, S.
przewalskii had higher levels of photoprotective stress compounds than S. chinensis. The results suggested that these two species possess cold-induced photoinhibition functions and show the inherent, season-dependent
differences in the amounts of the stress-related compounds. 相似文献
102.
While the concept of using polymer-based sustained-release delivery systems to maintain therapeutic concentration of protein
drugs for extended periods of time has been well accepted for decades, there has not been a single product in this category
successfully commercialized to date despite clinical and market demands. To achieve successful systems, technical difficulties
ranging from protein denaturing during formulation process and the course of prolonged in vivo release, burst release, and incomplete release, to low encapsulation efficiency and formulation complexity have to be simultaneously
resolved. Based on this updated understanding, formulation strategies attempting to address these aspects comprehensively
were reported in recent years. This review article (with 134 citations) aims to summarize recent studies addressing the issues
above, especially those targeting practical industrial solutions. Formulation strategies representative of three areas, microsphere
technology using degradable hydrophobic polymers, microspheres made of water soluble polymers, and hydrophilic in vivo gelling systems will be selected and introduced. To better understand the observations and conclusions from different studies
for different systems and proteins, physicochemical basis of the technical challenges and the pros and cons of the corresponding
formulation methods will be discussed. 相似文献
103.
Tuo Deng Christopher J. Lyon Laurie J. Minze Jianxin Lin Jia Zou Joey Z. Liu Yuelan Ren Zheng Yin Dale J. Hamilton Patrick R. Reardon Vadim Sherman Helen Y. Wang Kevin J. Phillips Paul Webb Stephen T.C. Wong Rong-fu Wang Willa A. Hsueh 《Cell metabolism》2013,17(3):411-422
Highlights? Obesity enhances MHCII expression in primary human and mouse adipocytes ? Adipocytes activate CD4+ ARTs via MHCII and leptin to induce adipose inflammation ? Macrophage changes in adipose follow adipocyte and T cell interactions during HFD ? Adaptive immune mechanisms are essential to obesity-induced adipose inflammation 相似文献
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105.
七角井是新疆地区最早发现的细石器遗址,位于新疆维吾尔自治区哈密地区西北部、天山南麓东段的一处山间小盆地内。2019年调查首次在该遗址发现原生地层和一处保存较完整的活动面遗迹,遗址出土石制品847件,年代为1.1万年。分析显示,该遗址石制品以优质燧石为原料生产小石叶和细石叶,多为生产过程中的副产品;工具加工简单,体现出明显的权宜性特征;这些迹象表明遗址为一处打制石器的临时性活动场所。这一发现为探讨更新世末到全新世初中亚干旱区古人类适应方式与文化交流提供了重要材料。 相似文献
106.
目的:研究以乙二醛为连接剂的聚乙烯亚胺(Polyethyleneimine,PEI)衍生物Polyimine-PEI对非洲绿猴肾癌细胞COS-7的转染活性和细胞毒性的影响。方法:以荧光素酶质粒为报告基因,研究高分子与DNA的复合物在COS-7细胞的转染活性,用MTT方法研究高分子对COS-7细胞的毒性。结果:COS-7细胞实验显示,Polyimine-PEI具有很低细胞毒性,其毒性显著低于PEI25kDa,同时也具有高效输送质粒的能力。结论:Polyimine-PEI是一种新型的高效,低毒在基因治疗领域有相当前景的非病毒载体。 相似文献
107.
文章主要阐述了音乐对脑的多方面正性影响,主要包括空间推理能力的提升(莫扎特效应),学习记忆能力的增强等;在痰病治疗方面,则集中于音乐对精神和神经性疾病,如癫痫、孤独症、帕金森综合症、老年性痴呆等的影响。目前,音乐对机体产生的这些正性影响的具体分子机制还不十分清晰,本文将细述在音乐暴露的情况下,大脑中相关神经细胞的生长、分化、凋亡及蛋白质合成的调控,某些神经递质(如多巴胺,五羟色胺,Y-氨基丁酸等)的合成与释放,类固醇激素分泌对脑内物质合成与分泌的调节,以及BDNF/TrkB信号通路和NGF的调节。 相似文献
108.
目的:研究以乙二醛为连接剂的聚乙烯亚胺(Polyethyleneimine,PEI)衍生物Polyimine-PEI对非洲绿猴肾癌细胞COS-7的转染活性和细胞毒性的影响。方法:以荧光素酶质粒为报告基因,研究高分子与DNA的复合物在COS-7细胞的转染活性,用MTT方法研究高分子对COS-7细胞的毒性。结果:COS-7细胞实验显示,Polyimine-PEI具有很低细胞毒性,其毒性显著低于PEI25kDa,同时也具有高效输送质粒的能力。结论:Polyimine-PEI是一种新型的高效,低毒在基因治疗领域有相当前景的非病毒载体。 相似文献
109.
文章主要阐述了音乐对脑的多方面正性影响,主要包括空间推理能力的提升(莫扎特效应),学习记忆能力的增强等;在疾病治疗方面,则集中于音乐对精神和神经性疾病,如癫痫、孤独症、帕金森综合症、老年性痴呆等的影响。目前,音乐对机体产生的这些正性影响的具体分子机制还不十分清晰,本文将细述在音乐暴露的情况下,大脑中相关神经细胞的生长、分化、凋亡及蛋白质合成的调控,某些神经递质(如多巴胺,五羟色胺,γ-氨基丁酸等)的合成与释放,类固醇激素分泌对脑内物质合成与分泌的调节,以及BDNF/TrkB信号通路和NGF的调节。 相似文献
110.