全文获取类型
收费全文 | 514篇 |
免费 | 29篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 17篇 |
2020年 | 7篇 |
2019年 | 10篇 |
2018年 | 16篇 |
2017年 | 7篇 |
2016年 | 16篇 |
2015年 | 30篇 |
2014年 | 29篇 |
2013年 | 29篇 |
2012年 | 45篇 |
2011年 | 39篇 |
2010年 | 31篇 |
2009年 | 24篇 |
2008年 | 21篇 |
2007年 | 25篇 |
2006年 | 17篇 |
2005年 | 20篇 |
2004年 | 26篇 |
2003年 | 20篇 |
2002年 | 19篇 |
2001年 | 7篇 |
2000年 | 9篇 |
1999年 | 10篇 |
1998年 | 2篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1986年 | 5篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 6篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1970年 | 3篇 |
1968年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有543条查询结果,搜索用时 534 毫秒
71.
72.
73.
A mycological survey was carried out on the fruit surface of Indian jujube during its growth period (before harvest). A total
of 32 microfungi belonging to 20 genera were isolated by surface washing technique. Artificial inoculations with the isolated
myco-propagules were also performed in mature jujube fruits and most of them were able to cause rot of varying severity. However,
Monodictys castaneae, Eupenicillium lapidosum, Paecilomyces fumosoroseus, Trichurus spiralis and Acremonium spp., although
present on the fruit surface, were not able to cause rot, indicating lack of specific macerating enzymes necessary for postharvest
pathogenesis.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
74.
75.
Bahare Shokoohian Babak Negahdari Hamidreza Aboulkheyr Es Manuchehr Abedi-Valugerdi Kaveh Baghaei Tarun Agarwal Tapas Kumar Maiti Moustapha Hassan Mustapha Najimi Massoud Vosough 《Journal of cellular and molecular medicine》2021,25(18):8602-8614
Hepatocellular carcinoma (HCC), the most common type of liver cancer, is usually a latent and asymptomatic malignancy caused by different aetiologies, which is a result of various aberrant molecular heterogeneity and often diagnosed at advanced stages. The incidence and prevalence have significantly increased because of sedentary lifestyle, diabetes, chronic infection with hepatotropic viruses and exposure to aflatoxins. Due to advanced intra- or extrahepatic metastasis, recurrence is very common even after radical resection. In this paper, we highlighted novel therapeutic modalities, such as molecular-targeted therapies, targeted radionuclide therapies and epigenetic modification-based therapies. These topics are trending headlines and their combination with cell-based immunotherapies, and gene therapy has provided promising prospects for the future of HCC treatment. Moreover, a comprehensive overview of current and advanced therapeutic approaches is discussed and the advantages and limitations of each strategy are described. Finally, very recent and approved novel combined therapies and their promising results in HCC treatment have been introduced. 相似文献
76.
Inderpreet Sur 《Current Genomics》2009,10(8):594-603
77.
78.
Binding affinity and in vitro cytotoxicity of harmaline targeting different motifs of nucleic acids: An ultimate drug designing approach 下载免费PDF全文
Paromita Bhattacharjee Tapas Ghosh Sarita Sarkar Prateek Pandya Kakali Bhadra 《Journal of molecular recognition : JMR》2018,31(4)
The work focuses towards interaction of harmaline, with nucleic acids of different motifs by multispectroscopic and calorimetric techniques. Findings of this study suggest that binding constant varied in the order single‐stranded (ss) poly(A) > double‐stranded calf thymus (CT) DNA > double‐stranded poly(G)·poly(C) > clover leaf tRNAPhe. Prominent structural changes of ss poly(A), CT DNA, and poly(G)· poly(C) with concomitant induction of optical activity in the bound achiral alkaloid molecule was observed, while with tRNAPhe, very weak induced circular dichroism perturbation was seen. The interaction was predominantly exothermic, enthalpy driven, and entropy favored with CT DNA and poly(G)·poly(C), while it was entropy driven with poly(A) and tRNAPhe. Intercalated state of harmaline inside poly(A), CT DNA, and poly(G)·poly(C) was shown by viscometry, ferrocyanide quenching, and molecular docking. All these findings unequivocally pointed out preference of harmaline towards ss poly(A) inducing self‐structure formation. Furthermore, harmaline administration caused a significant decrease in proliferation of HeLa and HepG2 cells with GI50 of 28μM and 11.2μM, respectively. Nucleic acid fragmentation, cellular ultramorphological changes, decreased mitochondrial membrane potential, upregulation of p53 and caspase 3, generation of reactive oxygen species, and a significant increase in the G2/M population made HepG2 more prone to apoptosis than are HeLa cells. 相似文献
79.
80.
Joseph Markowitz Tapas K. Mal Chunhua Yuan Nicholas B. Courtney Mitra Patel Andrew R. Stiff James Blachly Christopher Walker Ann‐Kathrin Eisfeld Albert de la Chapelle William E. Carson III 《Protein science : a publication of the Protein Society》2016,25(5):1069-1074
It was recently discovered that the NRAS isoform 5 (20 amino acids) is expressed in melanoma and results in a more aggressive cell phenotype. This novel isoform is responsible for increased phosphorylation of downstream targets such as AKT, MEK, and ERK as well as increased cellular proliferation. This structure report describes the NMR solution structure of NRAS isoform 5 to be used as a starting point to understand its biophysical interactions. The isoform is highly flexible in aqueous solution, but forms a helix‐turn‐coil structure in the presence of trifluoroethanol as determined by NMR and CD spectroscopy. 相似文献