全文获取类型
收费全文 | 2023篇 |
免费 | 94篇 |
出版年
2022年 | 5篇 |
2021年 | 27篇 |
2020年 | 10篇 |
2019年 | 12篇 |
2018年 | 13篇 |
2017年 | 26篇 |
2016年 | 42篇 |
2015年 | 57篇 |
2014年 | 58篇 |
2013年 | 110篇 |
2012年 | 109篇 |
2011年 | 111篇 |
2010年 | 71篇 |
2009年 | 61篇 |
2008年 | 123篇 |
2007年 | 103篇 |
2006年 | 120篇 |
2005年 | 120篇 |
2004年 | 122篇 |
2003年 | 144篇 |
2002年 | 132篇 |
2001年 | 64篇 |
2000年 | 50篇 |
1999年 | 58篇 |
1998年 | 27篇 |
1997年 | 25篇 |
1996年 | 15篇 |
1995年 | 12篇 |
1994年 | 12篇 |
1993年 | 20篇 |
1992年 | 25篇 |
1991年 | 23篇 |
1990年 | 18篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 17篇 |
1986年 | 17篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1981年 | 11篇 |
1980年 | 8篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 9篇 |
1975年 | 5篇 |
1973年 | 8篇 |
1970年 | 4篇 |
排序方式: 共有2117条查询结果,搜索用时 21 毫秒
51.
52.
53.
Matsumoto Narihisa Mototake Yoh-ichi Kawano Kenji Okada Masato Sugase-Miyamoto Yasuko 《Journal of computational neuroscience》2021,49(3):251-257
Journal of Computational Neuroscience - Feed-forward deep neural networks have better performance in object categorization tasks than other models of computer vision. To understand the relationship... 相似文献
54.
Takemura Aya Matsumoto Junya Hashimoto Ryota Kawano Kenji Miura Kenichiro 《Journal of computational neuroscience》2021,49(3):273-282
Journal of Computational Neuroscience - When two-frame apparent motion stimuli are presented with an appropriate inter-stimulus interval (ISI), motion is perceived in the direction opposite to the... 相似文献
55.
Arakawa Tsutomu Tokunaga Masao Kita Yoshiko Niikura Takako Baker Richard W. Reimer Janice M. Leschziner Andres E. 《The protein journal》2021,40(6):867-875
The Protein Journal - Difference circular dichroism (CD) spectroscopy was used here to characterize changes in structure of flexible peptides upon altering their environments. Environmental changes... 相似文献
56.
Kazuki Okubo Kosuke Miyai Kimi Kato Takako Asano Akinori Sato 《Translational oncology》2021,14(9):101154
The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer cells by inducing histone acetylation cooperatively. The combination of romidepsin and simvastatin induced robust apoptosis and killed bladder cancer cells synergistically. In murine subcutaneous tumor models using MBT-2 cells, a 15-day treatment with 0.5 mg/kg romidepsin and 15 mg/kg simvastatin was well tolerated and inhibited tumor growth significantly. Mechanistically, the combination induced histone acetylation by activating AMPK. The combination also decreased the expression of HDACs, thus further promoting histone acetylation. This AMPK activation was essential for the combination's action because compound C, an AMPK inhibitor, suppressed the combination-induced histone acetylation and the combination's ability to induce apoptosis. We also found that the combination increased the expression of peroxisome proliferator-activated receptor (PPAR) γ, leading to reactive oxygen species production. Furthermore, the combination induced endoplasmic reticulum (ER) stress and this ER stress was shown to be associated with increased AMPK expression and histone acetylation, thus playing an important role in the combination's action. Our study also suggests there is a positive feedback cycle between ER stress induction and PPARγ expression. 相似文献
57.
Hideo Inoue Masaki Shimizu Takako Furukawa Takashi Tamura Miwa Matsui Eiko Ohtsuka 《Nucleosides, nucleotides & nucleic acids》2013,32(6-7):1503-1505
Abstract 2′-Deoxy- and 2′-O-methyl-5′-O-terpyridyl derivatives of adenosine and cytidine were synthesized and used to construct 5′-end-modified oligonucleotides. These antisense agents complexed with Cu(II) exclusively cleaved a complementary RNA oligomer at the site opposite the terpyridine-nucleoside residue. We also found that the terpyridine·Cu(II) moiety stabilizes 2′-O-methyl RNA duplex. These suggest that after RNA hybridization, the terpyridine moiety is close to the RNA strand, presumably in an end capping manner. 相似文献
58.
Yoji Kukita Junji Uchida Shigeyuki Oba Kazumi Nishino Toru Kumagai Kazuya Taniguchi Takako Okuyama Fumio Imamura Kikuya Kato 《PloS one》2013,8(11)
The detection of rare mutants using next generation sequencing has considerable potential for diagnostic applications. Detecting circulating tumor DNA is the foremost application of this approach. The major obstacle to its use is the high read error rate of next-generation sequencers. Rather than increasing the accuracy of final sequences, we detected rare mutations using a semiconductor sequencer and a set of anomaly detection criteria based on a statistical model of the read error rate at each error position. Statistical models were deduced from sequence data from normal samples. We detected epidermal growth factor receptor (EGFR) mutations in the plasma DNA of lung cancer patients. Single-pass deep sequencing (>100,000 reads) was able to detect one activating mutant allele in 10,000 normal alleles. We confirmed the method using 22 prospective and 155 retrospective samples, mostly consisting of DNA purified from plasma. A temporal analysis suggested potential applications for disease management and for therapeutic decision making to select epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). 相似文献
59.
60.