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151.
Selection and use of molecular markers for evaluation of DNA polymorphism in plants are couple of the most important approaches in the field of molecular genetics. The assessment of genetic diversity using morphological markers is not sufficient due to little differentiating traits among the species, genera or their individuals. Morphological markers are not only highly influenced by environmental factors but skilled assessment is also prerequisite to find the variations in plant genetic resources. Therefore, molecular markers are considered as efficient tools for detailed DNA based characterization of fruit crops. Molecular markers provide new directions to the efforts of plant breeders particularly in genetic variability, gene tags, gene localization, taxonomy, genetic diversity, phylogenetic analysis and also play an important role to decrease the time required for development of new and excellent cultivars. The success of molecular markers technology in genetic improvement programs depends on the close relationship among the plant breeders, biotechnologists, skilled manpower and good financial support. The present review describes application and success of molecular markers technology used for genetic improvement in different fruit crops. 相似文献
152.
Deeba Shamim Jairajpuri Afzal Hussain Khalida Nasreen Taj Mohammad Farah Anjum Md. Tabish Rehman Gulam Mustafa Hasan Mohamed F. Alajmi Md. Imtaiyaz Hassan 《Saudi Journal of Biological Sciences》2021,28(4):2423-2431
Coronavirus disease 2019 (COVID-19) has emerged from China and globally affected the entire population through the human-to-human transmission of a newly emerged virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The genome of SARS-CoV-2 encodes several proteins that are essential for multiplication and pathogenesis. The main protease (Mpro or 3CLpro) of SARS-CoV-2 plays a central role in its pathogenesis and thus is considered as an attractive drug target for the drug design and development of small-molecule inhibitors. We have employed an extensive structure-based high-throughput virtual screening to discover potential natural compounds from the ZINC database which could inhibit the Mpro of SARS-CoV-2. Initially, the hits were selected on the basis of their physicochemical and drug-like properties. Subsequently, the PAINS filter, estimation of binding affinities using molecular docking, and interaction analyses were performed to find safe and potential inhibitors of SARS-CoV-2 Mpro. We have identified ZINC02123811 (1-(3-(2,5,9-trimethyl-7-oxo-3-phenyl-7H-furo[3,2-g]chromen-6-yl)propanoyl)piperidine-4-carboxamide), a natural compound bearing appreciable affinity, efficiency, and specificity towards the binding pocket of SARS-CoV-2 Mpro. The identified compound showed a set of drug-like properties and preferentially binds to the active site of SARS-CoV-2 Mpro. All-atom molecular dynamics (MD) simulations were performed to evaluate the conformational dynamics, stability and interaction mechanism of Mpro with ZINC02123811. MD simulation results indicated that Mpro with ZINC02123811 forms a stable complex throughout the trajectory of 100 ns. These findings suggest that ZINC02123811 may be further exploited as a promising scaffold for the development of potential inhibitors of SARS-CoV-2 Mpro to address COVID-19. 相似文献
153.
Al-Bahlani Shadia M. Lakhtakia Ritu Al-Jaaidi Samiya S. Al-Sinawi Shadia S. Abd-Elmoety Shaymaa G. Al-Khabori Murtadha Osman Anjum H. A. Al-Baimani Khalid Shalaby Asem A. 《Journal of molecular histology》2021,52(3):621-633
Journal of Molecular Histology - Breast cancer is the leading cancer worldwide among women. Traditional clinicopathological prognostic and predictive markers need refining to improve clinical... 相似文献
154.
155.
Anjum Hamid Rather Rumysa Saleem Khan Taha Umair Wani Mushtaq A. Beigh Faheem A. Sheikh 《Biotechnology and bioengineering》2022,119(1):9-33
The arrangement and type of support has a significant impact on the efficiency of immobilized enzymes. 1-dimensional fibrous materials can be one of the most desirable supports for enzyme immobilization. This is due to their high surface area to volume ratio, internal porosity, ease of handling, and high mechanical stability, all of which allow a higher enzyme loading, release and finally lead to better catalytic efficiency. Fortunately, the enzymes can reside inside individual nanofibers to remain encapsulated and retain their three-dimensional structure. These properties can protect the enzyme's tolerance against harsh conditions such as pH variations and high temperature, and this can probably enhance the enzyme's stability. This review article will discuss the immobilization of enzymes on synthetic polymers, which are fabricated into nanofibers by electrospinning. This technique is rapidly gaining popularity as one of the most practical ways to fibricate polymer, metal oxide, and composite micro or nanofibers. As a result, there is interest in using nanofibers to immobilize enzymes. Furthermore, present research on electrospun nanofibers for enzyme immobilization is primarily limited to the lab scale and industrial scale is still challanging. The primary future research objectives of this paper is to investigate the use of electrospun nanofibers for enzyme immobilization, which includes increasing yield to transfer biological products into commercial applications. 相似文献
156.
Tang Ke Roca Jorjethe Chen Rong Ansari Anjum Liang Jie 《Journal of biological physics》2022,48(2):129-150
Journal of Biological Physics - Pseudoknotted RNA molecules play important biological roles that depend on their folded structure. To understand the underlying principles that determine their... 相似文献
157.
Daniel Conroy-Beam James R. Roney Aaron W. Lukaszewski David M. Buss Kelly Asao Agnieszka Sorokowska Piotr Sorokowski Toivo Aavik Grace Akello Mohammad Madallh Alhabahba Charlotte Alm Naumana Amjad Afifa Anjum Chiemezie S. Atama Derya Atamtürk Duyar Richard Ayebare Carlota Batres Mons Bendixen Maja Zupančič 《Evolution and human behavior》2019,40(5):479-491
Mate choice lies close to differential reproduction, the engine of evolution. Patterns of mate choice consequently have power to direct the course of evolution. Here we provide evidence suggesting one pattern of human mate choice—the tendency for mates to be similar in overall desirability—caused the evolution of a structure of correlations that we call the d factor. We use agent-based models to demonstrate that assortative mating causes the evolution of a positive manifold of desirability, d, such that an individual who is desirable as a mate along any one dimension tends to be desirable across all other dimensions. Further, we use a large cross-cultural sample with n = 14,478 from 45 countries around the world to show that this d-factor emerges in human samples, is a cross-cultural universal, and is patterned in a way consistent with an evolutionary history of assortative mating. Our results suggest that assortative mating can explain the evolution of a broad structure of human trait covariation. 相似文献
158.
Coralie Reger de Moura Maxime Battistella Anjum Sohail Anne Caudron Jean Paul Feugeas Marie‐Pierre Podgorniak Cecile Pages Sarra Mazouz Dorval Oren Marco Suzanne Menashi Rafael Fridman Celeste Lebb Samia Mourah Fanlie Jouenne 《Pigment cell & melanoma research》2019,32(5):697-707
The discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase family that signals in response to collagen and that has been implicated in cancer progression. In the present study, we investigated the expression and role of DDR1 in human melanoma progression. Immunohistochemical staining of human melanoma specimens (n = 52) shows high DDR1 expression in melanoma lesions that correlates with poor prognosis. DDR1 expression was associated with the clinical characteristics of Clark level and ulceration and with BRAF mutations. Downregulation of DDR1 by small interfering RNA (siRNA) in vitro inhibited melanoma cells malignant properties, migration, invasion, and survival in several human melanoma cell lines. A DDR tyrosine kinase inhibitor (DDR1‐IN‐1) significantly inhibited melanoma cell proliferation in vitro, and ex vivo and in tumor xenografts, underlining the promising potential of DDR1 inhibition in melanoma. 相似文献
159.
Ali Muhammad Mehmood Azra Anjum Muhammad Sohail Tarrar Moazzam Nazir Khan Shaheen N. Riazuddin Sheikh 《Molecular and cellular biochemistry》2015,403(1-2):267-276
Molecular and Cellular Biochemistry - Type 1 diabetes mellitus (DM) is a strong risk factor for the development of diabetic cardiomyopathy (DCM) which is the leading cause of morbidity and... 相似文献
160.
Polymer Solar Cells with Efficiency >10% Enabled via a Facile Solution‐Processed Al‐Doped ZnO Electron Transporting Layer 下载免费PDF全文
Lethy Krishnan Jagadamma Mohammed Al‐Senani Abdulrahman El‐Labban Issam Gereige Guy O. Ngongang Ndjawa Jorge C. D. Faria Taesoo Kim Kui Zhao Federico Cruciani Dalaver H. Anjum Martyn A. McLachlan Pierre M. Beaujuge Aram Amassian 《Liver Transplantation》2015,5(12)
A facile and low‐temperature (125 °C) solution‐processed Al‐doped ZnO (AZO) buffer layer functioning very effectively as electron accepting/hole blocking layer for a wide range of polymer:fullerene bulk heterojunction systems, yielding power conversion efficiency in excess of 10% (8%) on glass (plastic) substrates is described. The ammonia‐treatment of the aqueous AZO nanoparticle solution produces compact, crystalline, and smooth thin films, which retain the aluminum doping, and eliminates/reduces the native defects by nitrogen incorporation, making them good electron transporters and energetically matched with the fullerene acceptor. It is demonstrated that highly efficient solar cells can be achieved without the need for additional surface chemical modifications of the buffer layer, which is a common requirement for many metal oxide buffer layers to yield efficient solar cells. Also highly efficient solar cells are achieved with thick AZO films (>50 nm), highlighting the suitability of this material for roll‐to‐roll coating. Preliminary results on the applicability of AZO as electron injection layer in F8BT‐based polymer light emitting diode are also presented. 相似文献