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排序方式: 共有1270条查询结果,搜索用时 125 毫秒
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Raman Dhariwal Vijay Gahlaut Bhaganagare R. Govindraj Dharmendra Singh Saloni Mathur Shailendra Vyas Rajib Bandopadhyay Jitendra Paul Khurana Akhilesh Kumar Tyagi Kumble Vinod Prabhu Kunal Mukhopadhyay Harindra Singh Balyan Pushpendra Kumar Gupta 《Functional & integrative genomics》2015,15(2):233-245
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Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses. These systems are structurally and biochemically well-characterized and are simplest-case paradigms of self-assembly. Published data suggest that capsid and glycoprotein assembly is subject to allosteric regulation, that is regulation at the level of conformational change. The hypothesis that allostery is a common theme in viruses suggests that deregulation of capsid and glycoprotein assembly by small molecule effectors will be an attractive antiviral strategy, as has been demonstrated with hepatitis B virus. 相似文献
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Perin EC Tian M Marini FC Silva GV Zheng Y Baimbridge F Quan X Fernandes MR Gahremanpour A Young D Paolillo V Mukhopadhyay U Borne AT Uthamanthil R Brammer D Jackson J Decker WK Najjar AM Thomas MW Volgin A Rabinovich B Soghomonyan S Jeong HJ Rios JM Steiner D Robinson S Mawlawi O Pan T Stafford J Kundra V Li C Alauddin MM Willerson JT Shpall E Gelovani JG 《PloS one》2011,6(9):e22949
The long-term fate of stem cells after intramyocardial delivery is unknown. We used noninvasive, repetitive PET/CT imaging with [(18)F]FEAU to monitor the long-term (up to 5 months) spatial-temporal dynamics of MSCs retrovirally transduced with the sr39HSV1-tk gene (sr39HSV1-tk-MSC) and implanted intramyocardially in pigs with induced acute myocardial infarction. Repetitive [(18)F]FEAU PET/CT revealed a biphasic pattern of sr39HSV1-tk-MSC dynamics; cell proliferation peaked at 33-35 days after injection, in periinfarct regions and the major cardiac lymphatic vessels and lymph nodes. The sr39HSV1-tk-MSC-associated [(18)F]FEAU signals gradually decreased thereafter. Cardiac lymphography studies using PG-Gd-NIRF813 contrast for MRI and near-infrared fluorescence imaging showed rapid clearance of the contrast from the site of intramyocardial injection through the subepicardial lymphatic network into the lymphatic vessels and periaortic lymph nodes. Immunohistochemical analysis of cardiac tissue obtained at 35 and 150 days demonstrated several types of sr39HSV1-tk expressing cells, including fibro-myoblasts, lymphovascular cells, and microvascular and arterial endothelium. In summary, this study demonstrated the feasibility and sensitivity of [(18)F]FEAU PET/CT imaging for long-term, in-vivo monitoring (up to 5 months) of the fate of intramyocardially injected sr39HSV1-tk-MSC cells. Intramyocardially transplanted MSCs appear to integrate into the lymphatic endothelium and may help improve myocardial lymphatic system function after MI. 相似文献
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Khan JA Kudgus RA Szabolcs A Dutta S Wang E Cao S Curran GL Shah V Curley S Mukhopadhyay D Robertson JD Bhattacharya R Mukherjee P 《PloS one》2011,6(6):e20347