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现代生物医学进展经过多项学术指标综合评定及同行专家评议推荐,贵刊被收录为"中国科技论文统计源期刊"(中国科技核心期刊)。特颁发此证书。 相似文献
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GP Dolan PR Myles SJ Brett JE Enstone RC Read PJ Openshaw MG Semple WS Lim BL Taylor J McMenamin KG Nicholson B Bannister JS Nguyen-Van-Tam;the Influenza Clinical Information Network 《PloS one》2012,7(8):e41638
Introduction
The Influenza Clinical Information Network (FLU-CIN) was established to gather detailed clinical and epidemiological information about patients with laboratory confirmed A(H1N1)pdm09 infection in UK hospitals. This report focuses on the clinical course and outcomes of infection in pregnancy.Methods
A standardised data extraction form was used to obtain detailed clinical information from hospital case notes and electronic records, for patients with PCR-confirmed A(H1N1)pdm09 infection admitted to 13 sentinel hospitals in five clinical ''hubs'' and a further 62 non-sentinel hospitals, between 11th May 2009 and 31st January 2010.Outcomes were compared for pregnant and non-pregnant women aged 15–44 years, using univariate and multivariable techniques.Results
Of the 395 women aged 15–44 years, 82 (21%) were pregnant; 73 (89%) in the second or third trimester. Pregnant women were significantly less likely to exhibit severe respiratory distress at initial assessment (OR = 0.49 (95% CI: 0.30–0.82)), require supplemental oxygen on admission (OR = 0.40 (95% CI: 0.20–0.80)), or have underlying co-morbidities (p-trend <0.001). However, they were equally likely to be admitted to high dependency (Level 2) or intensive care (Level 3) and/or to die, after adjustment for potential confounders (adj. OR = 0.93 (95% CI: 0.46–1.92). Of 11 pregnant women needing Level 2/3 care, 10 required mechanical ventilation and three died.Conclusions
Since the expected prevalence of pregnancy in the source population was 6%, our data suggest that pregnancy greatly increased the likelihood of hospital admission with A(H1N1)pdm09. Pregnant women were less likely than non-pregnant women to have respiratory distress on admission, but severe outcomes were equally likely in both groups. 相似文献34.
Integrated evaluation of DNA sequence variants of unknown clinical significance: application to BRCA1 and BRCA2 下载免费PDF全文
Goldgar DE Easton DF Deffenbaugh AM Monteiro AN Tavtigian SV Couch FJ;Breast Cancer Information Core 《American journal of human genetics》2004,75(4):535-544
Many sequence variants in predisposition genes are of uncertain clinical significance, and classification of these variants into high- or low-risk categories is an important problem in clinical genetics. Classification of such variants can be performed by direct epidemiological observations, including cosegregation with disease in families and degree of family history of the disease, or by indirect measures, including amino acid conservation, severity of amino acid change, and evidence from functional assays. In this study, we have developed an approach to the synthesis of such evidence in a multifactorial likelihood-ratio model. We applied this model to the analysis of three unclassified variants in BRCA1 and three in BRCA2. The evidence strongly suggests that two variants (C1787S in BRCA1 and D2723H in BRCA2) are deleterious, three (R841W in BRCA1 and Y42C and P655R in BRCA2) are neutral, and one (R1699Q in BRCA1) remains of uncertain significance. These results provide a demonstration of the utility of the model. 相似文献
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为了从仿生学的角度 ,获得复合材料构造的最优化设计的指导思想 ,用扫描电子显微镜考察了独角仙和锹形虫前翅中的小柱微细构造 ,结果在昆虫形态学方面也得到了一些新的见解 :1 )与甲虫前翅上下层相连的小柱 ,其形状和尺寸的大小因甲虫种类而异。不过 ,和以往的认识不同的是 ,两种甲虫前翅的小柱具有类似的结构 ,它们均为非中空的实柱 ,并由中心部和环状的几丁质纤维层构成。其中心部主要是溶解于KOH溶液的物质 (蛋白一类的物质 ) ,环状纤维层中的几丁质纤维 ,在层和层之间相互不同的方向排列着 ,并各自与前翅的上下层中的几丁质纤维连续地连接着 ;2 )独角仙前翅小柱的表面有复杂的纹样 ,而锹形虫的小柱表面只有非常简单的 (几乎没有 )纹样。此外 ,业已证明 ,上述的小柱构造对层状纤维强化复合材料而言 ,的确是一种非常巧妙的 ,可极其有效地提高复合材料抗剥离性能的生体构造。 相似文献
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图形简单几何特征的分辨及其相关错觉的定量研究 总被引:2,自引:1,他引:1
本实验用定量的心理物理测量方法,研究了在亮度对比与等亮度颜色对比的条件下,受试者分辨图形简单几何特征的能力以及与这些图形特征有关的错觉效应(Zoellner错觉、Muller-Lyer错觉、Ponzo错觉和Delboeuf错觉)。实验结果表明:受试者在亮度对比与颜色对比的条件下对线段平行度,线段长度与图形面积的分辨能力相同,与这些几何特征有关的错觉幅度也没有显著差异。但是,在等亮度颜色对比条件下, 相似文献
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Effect of lesion of nucleus robustus archistriatalis on call in bramble finch (Fringilla montifringilla) 总被引:3,自引:0,他引:3
The lesion of nucleus robustus archistriatalis (RA) has no effect on normal short calls in the bramble finch, but affects significantly the temporal and acoustic features of learned long calls. It causes the principal frequency of basic sound in monotone long calls to increase 500 cents, and to lose two upper partials. The lesion of RA not only results in the increased sound length of loud-sound and shortened coda of variable-tone long calls by 13.4%-22.1% and 21.2%-24.2% on average, respectively, but also makes the frequency rising coefficient (FRC) of even order partial tone in loud-sound drop 18.5%-25.8% on an average, and the step-up rate decrease 22.7% -24.0% on an average with the increase of frequencies. These results show that the control of temporal and frequency features of learned calls by RA matches to each other. Moreover, the lesion of bilateral RA can confuse the vocal pattern, and the produced long call has the character of both the mono- and variable-tone long calls. The prelude shows ri 相似文献