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排序方式: 共有1532条查询结果,搜索用时 31 毫秒
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Castañeda-Pérez Eduardo Jiménez-Morales Karina Castellanos-Ruelas Arturo Chel-Guerrero Luis Betancur-Ancona David 《International journal of peptide research and therapeutics》2021,27(3):1979-1988
International Journal of Peptide Research and Therapeutics - Characterized by uncontrolled, long-term high blood sugar levels, diabetes mellitus affects ever increasing numbers of people worldwide.... 相似文献
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Cortés-Sarabia Karen Bautista-Santos Isabel Cisneros-Sarabia Alondra Parra-Rojas Isela Estrada-Moreno Ana Karen Flores-Alfaro Eugenia Fernández-Tilapa Gloria Ramírez-Peralta Arturo Vences-Velázquez Amalia 《International journal of peptide research and therapeutics》2021,27(1):413-420
International Journal of Peptide Research and Therapeutics - Gardnerella vaginalis produces vaginolysin (VLY), a cholesterol-dependent cytolysin, responsible of the cellular lysis and epithelial... 相似文献
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Arturo Paganelli 《Plant biosystems》2013,147(1-3):103-108
Abstract THE DISCOVERING OF THE KETELEERIA'S POLLEN-GRAIN IN SOME QUATERNARY DEPOSITS OF THE CENTRAL AND NORTHERN ITALY. — The Author observes the specy of Keteleeria with the pollen analysis executed on deposits of turfys, clays and brown coals of some Umbro-Marchigiano and of the Po Plain localyties. The Keteleeria to-day is living only in China and Japan; in Italy it was living also during the early and middle Pleistocene. 相似文献
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Adelaide Greco Monica Ragucci Anna Rita Daniela Coda Alessandro Rosa Sara Gargiulo Raffaele Liuzzi Matteo Gramanzini Sandra Albanese Sabina Pappatà Marcello Mancini Arturo Brunetti Marco Salvatore 《PloS one》2013,8(10)
Background
Ultrasound is a valuable non-invasive tool used in obstetrics and gynecology to monitor the growth and well being of the human fetus. The laboratory mouse has recently emerged as an appropriate model for fetal and perinatal studies because morphogenetic processes in mice exhibit adequate homology to those in humans, and genetic manipulations are relatively simple to perform in mice. High-frequency ultrasound (HFUS) has recently become available for small animal preclinical imaging and can be used to study pregnancy and development in the mouse. The objective of the current study was to assess the main applications of HFUS in the evaluation of fetal growth and placental function and to better understand human congenital diseases.Methodology/Principal Findings
On each gestational day, at least 5 dams were monitored with HFUS; a total of ∼200 embryos were examined. Because it is not possible to measure each variable for the entire duration of the pregnancy, the parameters were divided into three groups as a function of the time at which they were measured. Univariate analysis of the relationship between each measurement and the embryonic day was performed using Spearman’s rank correlation (Rs). Continuous linear regression was adopted for multivariate analysis of significant parameters. All statistical tests were two-sided, and a p value of 0.05 was considered statistically significant.Conclusions/Significance
The study describes the main applications of HFUS to assess changes in phenotypic parameters in the developing CD1 mouse embryo and fetus during pregnancy and to evaluating physiological fetal and placental growth and the development of principal organs such as the heart, kidney, liver, brain and eyes in the embryonic mouse. A database of normal structural and functional parameters of mouse development will provide a useful tool for the better understanding of morphogenetic and cardiovascular anomalies in transgenic and mutant mouse models. 相似文献37.
Christian Castillo Galia Ramírez Carolina Valck Lorena Aguilar Ismael Maldonado Carlos Rosas Norbel Galanti Ulrike Kemmerling Arturo Ferreira 《PLoS neglected tropical diseases》2013,7(8)
Background
9 million people are infected with Trypanosoma cruzi in Latin America, plus more than 300,000 in the United States, Canada, Europe, Australia, and Japan. Approximately 30% of infected individuals develop circulatory or digestive pathology. While in underdeveloped countries transmission is mainly through hematophagous arthropods, transplacental infection prevails in developed ones.Methodology/Principal Findings
During infection, T. cruzi calreticulin (TcCRT) translocates from the endoplasmic reticulum to the area of flagellum emergence. There, TcCRT acts as virulence factor since it binds maternal classical complement component C1q that recognizes human calreticulin (HuCRT) in placenta, with increased parasite infectivity. As measured ex vivo by quantitative PCR in human placenta chorionic villi explants (HPCVE) (the closest available correlate of human congenital T. cruzi infection), C1q mediated up to a 3–5-fold increase in parasite load. Because anti-TcCRT and anti-HuCRT F(ab′)2 antibody fragments are devoid of their Fc-dependent capacity to recruit C1q, they reverted the C1q-mediated increase in parasite load by respectively preventing its interaction with cell-bound CRTs from both parasite and HPCVE origins. The use of competing fluid-phase recombinant HuCRT and F(ab′)2 antibody fragments anti-TcCRT corroborated this. These results are consistent with a high expression of fetal CRT on placental free chorionic villi. Increased C1q-mediated infection is paralleled by placental tissue damage, as evidenced by histopathology, a damage that is ameliorated by anti-TcCRT F(ab′)2 antibody fragments or fluid-phase HuCRT.Conclusions/Significance
T. cruzi infection of HPCVE is importantly mediated by human and parasite CRTs and C1q. Most likely, C1q bridges CRT on the parasite surface with its receptor orthologue on human placental cells, thus facilitating the first encounter between the parasite and the fetal derived placental tissue. The results presented here have several potential translational medicine aspects, specifically related with the capacity of antibody fragments to inhibit the C1q/CRT interactions and thus T. cruzi infectivity. 相似文献38.
Carlos Arturo García-Alzate Flavio Lima Donald Charles Taphorn Jose Ivan Mojica Alexander Urbano-Bonilla Tulio Franco Teixeira 《Journal of fish biology》2020,96(6):1444-1453
Hyphessobrycon chiribiquete n. sp. is described from the Río Caquetá drainage in Colombia and the Río Ucayali drainage in Peru, western Amazon. The new species is diagnosed from its congeners by having the following combination of characters: a conspicuous narrow midlateral stripe, starting on the sides of the body behind the opercle near the lateral line; lateral stripe overlapped anteriorly with a vertically elongated humeral blotch; inner premaxillary teeth pentacuspid; margin of anal fin falcate in mature males. 相似文献
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Adolfo López-Esparza Aurelio Álvarez-Vargas Héctor M. Mora-Montes Arturo Hernández-Cervantes Ma. Del Carmen Cano-Canchola Arturo Flores-Carreón 《Archives of microbiology》2013,195(7):499-506
Sporothrix schenckii is a fungal pathogen of humans and the etiological agent of sporotrichosis. In fungi, proper protein glycosylation is usually required for normal composition of cell wall and virulence. Upon addition of precursor oligosaccharides to nascent proteins in the endoplasmic reticulum, glycans are further modified by Golgi-glycosyl transferases. In order to add sugar residues to precursor glycans, nucleotide diphosphate sugars are imported from the cytosol to the Golgi lumen, the sugar is transferred to glycans, and the resulting nucleoside diphosphate is dephosphorylated by the nucleoside diphosphatase Gda1 before returning to cytosol. Here, we isolated the open reading frame SsGDA1 from a S. schenckii genomic DNA library. In order to confirm the function of SsGda1, we performed complementation assays in a Saccharomyces cerevisiae gda1? null mutant. Our results indicated that SsGDA1 restored the nucleotide diphosphatase activity to wild-type levels and therefore is a functional ortholog of S. cerevisiae GDA1. 相似文献
40.