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The role of introns in evolution 总被引:6,自引:0,他引:6
J H Rogers 《FEBS letters》1990,268(2):339-343
What are the roles of 'classical' introns in the evolution of nuclear genes, and what was the origin of these introns? Exon shuffling has been important in the evolution of cell surface and extracellular proteins, but the evidence for it in respect of intracellular proteins is weak. Intron distributions imply that some introns have been removed while others have been inserted in the course of evolution: ancestral patterns of introns may thus have been obscured. Recent evidence on the self-splicing and reverse-splicing abilities of Group II introns supports the hypothesis that these could have been the ancestors of classical introns. 相似文献
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Environmental Biology of Fishes - 相似文献
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F S Apple M A Rogers D C Casal L Lewis J L Ivy J W Lampe 《European journal of applied physiology and occupational physiology》1987,56(1):49-52
Total creatine kinase (CK) and CK MB activities were determined in gastrocnemius muscle and serum obtained from 14 female marathon runners. The level of CK MB in muscle increased significantly (p less than 0.05) after chronic exercise training from 5.3% to 10.5% of the total CK activity, but not after acute exercise (post-marathon 8.9%). No significant differences in total CK activities were detected. However, the total CK activity in the muscles were significantly (p less than 0.05) less than those previously reported from the muscle of men runners (1800 U/g, 3000 U/g respectively). No significant correlation existed between fiber type and muscle CK MB activity. Additionally, trace amounts of mitochondrial CK and CK BB were present in muscle homogenates. A significant correlation was observed in the increase in mean serum total CK (597 UL-1) and CK MB (23 UL-1) activities 24 h after the race (r = 0.97, p less than 0.05). These results suggest that gastrocnemius muscle in women adapts to training with increased CK MB activities and imply that skeletal muscle is the major source of elevated serum CK MB activities in women marathon runners. 相似文献
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Nine schizophrenic patients participated in a study which explored whether EEG feedback techniques could effect changes in the EEG similar to those associated with neuroleptic-induced improvement. During five sessions, each patient was presented feedback signals which continuously refected the discrepancy between characteristics of the patient's EEG power spectral profile and spectral profile characteristics associated by past research with neuroleptic induced clinical improvement. Significant within-session changes were observed for two of three EEG power spectrum bands of interest. No significant session-to-session EEG changes were observed. The results suggest that the EEG of schizophrenics can be temporarily altered, using feedback techniques, in a way that mimics the EEG changes that have been shown to occur with neuroleptic induced clinical improvement.The authors are indebted to Turan M. Itil, John W. Fredrickson, Michael Madwed, and Irene B. Francis. Senior authorship is shared equally. 相似文献
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Abstract: Phenylacetic acid, the major metabolite of phenylethylamine, has been identified and quantitated in rat brain regions by capillary column high-resolution gas chromatography mass spectrometry. Its distribution is heterogeneous and correlates with that of phenylethylamine. The values obtained were (ng/g ± SEM): whole brain, 31.2 ± 2.7; caudate nucleus, 64.6 ± 6.5; hypothalamus, 60.1 ± 7.4; cerebellum, 31.3 ± 2.9; brainstem, 33.1 ± 3.3, and the "rest," 27.6 ± 3.0. 相似文献
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