共查询到20条相似文献,搜索用时 15 毫秒
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Gutierrez S Javed A Tennant DK van Rees M Montecino M Stein GS Stein JL Lian JB 《The Journal of biological chemistry》2002,277(2):1316-1323
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Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase 总被引:1,自引:0,他引:1 下载免费PDF全文
Dhawan P Peng X Sutton AL MacDonald PN Croniger CM Trautwein C Centrella M McCarthy TL Christakos S 《Molecular and cellular biology》2005,25(1):472-487
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Role of specific CCAAT/enhancer-binding protein isoforms in intestinal epithelial cells 总被引:3,自引:0,他引:3
Gheorghiu I Deschênes C Blais M Boudreau F Rivard N Asselin C 《The Journal of biological chemistry》2001,276(47):44331-44337
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Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. 总被引:14,自引:0,他引:14 下载免费PDF全文
To investigate the role of C/EBP family members during adipocyte differentiation in vivo, we have generated mice lacking the C/EBPbeta and/or C/EBPdelta by gene targeting. Approximately 85% of C/EBPbeta(-/-).delta(-/-) mice died at the early neonatal stage. By 20 h after birth, brown adipose tissue of the interscapular region in wild-type mice contained many lipid droplets, whereas C/EBPbeta(-/-).delta(-/-) mice did not accumulate droplets. In addition, the epidydimal fat pad weight of surviving adult C/EBPbeta(-/-).delta(-/-) mice was significantly reduced compared with wild-type mice. However, these adipose tissues in C/EBPbeta(-/-).delta(-/-) mice exhibit normal expression of C/EBPalpha and PPARgamma, despite impaired adipogenesis. These results demonstrated that C/EBPbeta and C/EBPdelta have a synergistic role in terminal adipocyte differentiation in vivo. The induction of C/EBPalpha and PPARgamma does not always require C/EBPbeta and C/EBPdelta, but co-expression of C/EBPalpha and PPARgamma is not sufficient for complete adipocyte differentiation in the absence of C/EBPbeta and C/EBPdelta. 相似文献