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Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. 总被引:14,自引:0,他引:14 下载免费PDF全文
To investigate the role of C/EBP family members during adipocyte differentiation in vivo, we have generated mice lacking the C/EBPbeta and/or C/EBPdelta by gene targeting. Approximately 85% of C/EBPbeta(-/-).delta(-/-) mice died at the early neonatal stage. By 20 h after birth, brown adipose tissue of the interscapular region in wild-type mice contained many lipid droplets, whereas C/EBPbeta(-/-).delta(-/-) mice did not accumulate droplets. In addition, the epidydimal fat pad weight of surviving adult C/EBPbeta(-/-).delta(-/-) mice was significantly reduced compared with wild-type mice. However, these adipose tissues in C/EBPbeta(-/-).delta(-/-) mice exhibit normal expression of C/EBPalpha and PPARgamma, despite impaired adipogenesis. These results demonstrated that C/EBPbeta and C/EBPdelta have a synergistic role in terminal adipocyte differentiation in vivo. The induction of C/EBPalpha and PPARgamma does not always require C/EBPbeta and C/EBPdelta, but co-expression of C/EBPalpha and PPARgamma is not sufficient for complete adipocyte differentiation in the absence of C/EBPbeta and C/EBPdelta. 相似文献
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Role of specific CCAAT/enhancer-binding protein isoforms in intestinal epithelial cells 总被引:3,自引:0,他引:3
Gheorghiu I Deschênes C Blais M Boudreau F Rivard N Asselin C 《The Journal of biological chemistry》2001,276(47):44331-44337
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Nanbu-Wakao R Fujitani Y Masuho Y Muramatu M Wakao H 《Molecular endocrinology (Baltimore, Md.)》2000,14(2):307-316
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CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation 总被引:4,自引:0,他引:4 下载免费PDF全文
Shirakawa K Maeda S Gotoh T Hayashi M Shinomiya K Ehata S Nishimura R Mori M Onozaki K Hayashi H Uematsu S Akira S Ogata E Miyazono K Imamura T 《Molecular and cellular biology》2006,26(16):6105-6116