Studies on the effect of monoamine antagonists on the morphogenesis of the newt

The effects of three monoamine antagonists, p-chlorophenylalanine, diethyldithiocarbamate and propranolol on the morphogenesis of newt embryos were studied. Antagonists were administered during late blastula through neurula stages. In a concentration of 1 mM, all three arrested gastrulation and caused disintegration of the embryos. Lower concentrations (0.1-0.5 mM) retarded morphogenetic movements in the gastrulation and caused malformations especially in the anterior parts of the embryos; pigmentation was delayed by 1 or 2 days. In addition, p-CIPhe inhibited yolk granule degradation in the notochord and DEDTC caused notochordal hypertrophy. The results show that interference with synthesis or action of catecholamines and serotonin affects morphogenesis. With the methods used it is not possible to discover exactly how monoamines regulate the morphogenetic events because of the unspecific side effects of the antagonists and the feedback interactions between the monoamines.     

动态增强磁共振扫描与超声弹性成像对乳腺癌的诊断价值探讨

目的:探讨动态增强磁共振成像扫描与超声弹性成像对乳腺癌良恶性肿瘤的诊断价值,为临床诊断提供影像学依据。方法:回顾性分析2009年10月至2013年5月在我院经穿刺或手术病理证实为乳腺癌的59例患者的临床资料,患者术前均行超声与动态增强MR检查。依据病理组织活检和临床随访分别评价动态增强MR和UE对乳腺癌诊断的准确性。结果:DCE-MRI检测共发现病灶59个,55个初步诊断乳腺恶性肿瘤(BI-RADS 4-5),4个诊断为良性(BI-RADS 3),诊断准确率为93.22%(55/59)。UE对59个病灶进行评分,54个评分为乳腺恶性肿瘤,5个评分为良性,诊断率为91.53%(54/59)。UE检测乳腺癌的敏感性明显低于DCE-MRI及DCE-MRI+UE,DCE-MRI检测乳腺癌的特异性明显低于UE及DCE-MRI+UE,差异具有统计学意义(P0.05)。DCE-MRI+UE诊断乳腺癌的准确率为96.61%(57/59),明显高于DCE-MRI或UE单独检测的准确率(P0.05)。结论:动态增强MR诊断乳腺癌的敏感性较高,而超声弹性成像的特异性较好,两者联合可提高诊断准确率,对乳腺癌的早期诊断具有重要的临床应用价值。     

Studies on the the Isoleucine Fermentation

Accumulation of L-isoleucine and L-valine was studied on 14 genera, 47 species and 110 strains of aerobic bacteria using bacterial type cultures. A large amount of L-isoleucine and a small amount of L-valine accumulated when 1% of DL-α-aminobutyric acid was added to the culture medium. As a rule, facultative aerobes such as Aerobacter, Erwinia, Serratia and Bacillus showed good accumulation. In the absence of α-aminobutyric acid, powerful L-isoleucine accumulators produced a large amount of L-valine, although the accumulation of L- isoleucine was scarcely observed under that condition. In the presence of α-aminobutyric acid, the accumulation of L-valine was generally suppressed, but in several strains, on the contrary, the accumulation increased as well as that of L-isoleucine. When DL-threonine was used instead of α-aminobutyric acid, the amount of L-isoleucine accumulated was not as high as that with α-aminobutyric acid in almost all strains except Serratia marcescens. It was concluded that a distinct relationship between bacterial genera or species and accumulation of L-isoleucine did not exist, that is, powerful accumulators were limited to special strains, and that the addition of α-aminobutyric acid was necessary for the accumulation of a large amount of L-isoleucine.     

用菌紫质薄膜传感器进行图像边缘检测的研究

应用菌紫质人工沉淀膜所具有的与动物视网膜类似的微分光电响应特性,以该人工膜为传感器构建了一个可检测图像边缘的原理系统,并成功地检测到了简单图像的边缘。本文的结果除进一步说明了菌紫质分子在图像技术中的应用前途外,还说明了这种分子在视觉功能模拟和人工视觉等方面的良好应用前景 。     

凶险型前置胎盘对孕产妇的危害性研究

目的:探讨凶险型前置胎盘对孕产妇的危害性。方法:选择我院2009年3月至2012年3月收治的凶险性前置胎盘40例,对其临床资料进行回顾性分析。结果:植入型前置胎盘(植入组)占凶险型前置胎盘的55%(22例),非植入型前置胎盘(非植入组)占45%(18例)。植入组产前出血18例,占81.8%,非植入组产前出血8例,占44.4%,差异有统计学意义。植入组完全性前置胎盘17例,占77.3%;部分性4例,占18.2%;边缘性1例,占4.5%。非植入组分别为5例,占27.8%;1例,占5.6%;12例,占66.7%。两组之间比较差异具有统计学意义(P<0.05)。两组术前Hb值无明显差异(P>0.05),术后非植入组Hb水平高于植入组,手术时间、术中出血量、产后出血均显著少于植入组,差异均有统计学意义(P<0.05)。非植入组术中输血、切除子宫、应用宫腔纱条的百分率均显著低于植入组(P<0.05)。两组术中刮宫、徒手剥胎盘的百分率比较均无明显差异(P>0.05)。结论:对于凶险型前置胎盘孕产妇,产前应做好预防保健,术中加强观察,术中术后放置腹腔引流管,最大限度的降低对孕产妇的危害,确保母婴安全。