超声造影定量参数联合血清TSH、Tg、外周血NLR在甲状腺结节良恶性诊断中的应用价值

摘要 目的：探讨超声造影定量参数联合血清促甲状腺激素（TSH）、甲状腺球蛋白（Tg）、外周血中性粒细胞与淋巴细胞比值（NLR）在甲状腺结节良恶性诊断中的应用价值。方法：选取2020年7月到2022年5月我院收治的80例甲状腺结节患者,根据病理学检查结果将其分为良性组(53例）和恶性组（27例）。所有甲状腺结节患者均行甲状腺超声造影并记录定量参数,检测血清TSH、Tg水平,计算NLR。以术后病理结果为准,采用受试者工作特征（ROC）曲线分析超声造影定量参数、血清TSH、Tg及NLR鉴别诊断甲状腺良恶性结节的价值。结果：经组织病理学确诊恶性甲状腺结节27例,良性甲状腺结节53例。恶性组超声造影定量参数平均渡越时间(mTT)、曲线下面积（AUCceus）低于良性组（P＜0.05）,血清TSH、Tg水平及NLR均高于良性组（P＜0.05）。超声造影定量参数mTT、AUCceus联合血清TSH、Tg及NLR鉴别诊断良恶性甲状腺结节的曲线下面积高于以上五项指标单独诊断。结论：恶性甲状腺结节患者超声造影定量参数mTT、AUCceus降低,且血清TSH、Tg水平及NLR增高,超声造影定量参数mTT、AUCceus联合血清TSH、Tg及NLR可提高鉴别诊断良恶性甲状腺结节的效能。     

超声多技术联合在良恶性甲状腺结节鉴别诊断中的应用价值

摘要 目的：分析超声剪切波弹性成像（SWE）、超声造影（CEUS）、声触诊组织成像及定量（VTIQ）、促甲状腺激素（TSH）多技术联合在甲状腺结节良恶性鉴别诊断中的应用价值。方法：选取宁德市医院甲状腺不确定性质结节患者120例,以病理结果为金标准将其分为良性组和恶性组,分析两组SWE、CEUS、VTIQ各影像参数及术前TSH水平差异,绘制受试者工作特征曲线（ROC）评估上述技术联合对甲状腺结节良恶性的鉴别诊断价值。结果：120例患者共检出128个结节,其中良性47个,恶性81个;恶性组SWE中弹性模量值（Emax、Emin、Emean）均大于良性组（P＜0.01）;恶性组、良性组在CEUS中强化差异有显著性（P＜0.05）;VTIQ中恶性组剪切波速度（SWV）最大值、最小值、平均值均大于良性组（P＜0.01）;恶性组患者术前TSH水平高于良性组（P＜0.01）;ROC曲线分析显示,SWE、CEUS、VTIQ、TSH联合检测诊断甲状腺结节良恶性的效能最高,其灵敏度、特异度、准确度、曲线下面积（AUC）分别为85.19%、89.36%、86.72%、0.873。结论：SWE、CEUS、VTIQ、TSH联合对区分甲状腺结节良恶性有较高价值。     

甲状腺影像报告与数据系统(TI-RADS)分类鉴别良恶性甲状腺结节的临床应用价值

摘要 目的：探讨甲状腺影像报告与数据系统(TI-RADS)分类鉴别良恶性甲状腺结节(TN)的临床应用价值。方法：选取2016年5月至2019年12月我院收治的182例TN患者的临床资料进行回顾性分析,所有患者均完成超声检查和TI-RADS分类,以病理结果为金标准,比较良恶性结节超声征象及TI-RADS分布情况,并采用ROC曲线分析TI-RADS分类对TN良恶性的鉴别价值。结果：182例患者247个甲状腺结节中,良性172个,占比69.64%,恶性75个,占比30.36%;良性TN中实性结节、极低回声、边界模糊、微钙化和纵横比<1发生率以及结节直径均低于恶性TN,差异有统计学意义(P<0.05);良性TN的TI-RADS分类主要为1类（59.30%）和2类（31.40%）,恶性TN主要为3类（42.67%）和4类（46.67%）,两组分布比较差异有统计学意义(P<0.05);ROC曲线分析结果显示TI-RADS分类鉴别良恶性TN的AUC=0.939(95%CI：0.904~0.973,P<0.05),以TI-RADS 2类和3类为良性,4类和5类为恶性进行诊断,其灵敏度为0.893,特异度为0.907,准确率为0.903,一致性Kappa值为0.777。结论：TI-RADS分类鉴别良恶性甲状腺结节具有较高的临床应用价值,但也还存在一定误诊的可能性。     

彩色多普勒超声联合血清P53、midkine、S-TK1鉴别甲状腺结节良恶性的临床价值研究

摘要 目的：研究彩色多普勒超声联合血清P53、midkine及胸苷激酶1（S-TK1）鉴别甲状腺结节良恶性的临床价值。方法：将2015年1月～2020年1月我院收治的420例甲状腺结节患者纳入研究。将其按照术后病理学检查结果的不同分成恶性结节组150例与良性结节组270例。比较两组各项超声图像特征,血清P53、midkine及S-TK1水平。以受试者工作特征（ROC）曲线分析彩色多普勒超声联合血清P53、midkine、S-TK1或以上方式单独检测诊断甲状腺恶性结节的能效。结果：恶性结节组超声图像特征中形态不规则,边界不清晰,无包膜,内部钙化以及血流分级为2～3级人数占比均高于良性结节组（P＜0.05）。恶性结节组血清P53、midkine及S-TK1水平均高于良性结节组（P＜0.05）。经ROC曲线分析可得：彩色多普勒超声联合血清P53、midkine、S-TK1诊断甲状腺恶性结节的曲线下面积为0.895、灵敏度为0.92以及特异度为0.88均高于上述方式单独检测。结论：彩色多普勒超声联合血清P53、midkine及S-TK1鉴别甲状腺结节良恶性的临床价值较高。     

超声造影在甲状腺结节鉴别诊断及良性结节微波消融治疗中的应用价值

摘要 目的：研究超声造影在甲状腺结节鉴别诊断及良性结节微波消融治疗中的应用价值。方法：选取2015年1月～2018年2月我院收治的甲状腺结节患者100例作为研究对象,所有纳入对象均进行超声造影检查,分析甲状腺结节的超声造影特征,并与病理诊断结果进行对照。此外,将甲状腺良性结节患者以随机抽签法分成超声造影组31例和常规超声组30例。超声造影组微波消融治疗前后均予以超声造影配合,常规超声组微波消融治疗前后均予以常规超声配合。比较两组治疗前后甲状腺结节造影情况以及术后1年结节复发情况。结果：甲状腺恶性结节增强强度为低增强、增强模式为不均匀、无环绕增强占比均高于良性结节（均P＜0.05）。以病理诊断为金标准,超声造影诊断恶性甲状腺结节的灵敏度为92.31%、特异度为78.69%、准确度为84.00%。治疗后超声造影组甲状腺结节最长径、体积均低于常规超声组（均P＜0.05）。超声造影组术后1年结节复发率为0.00%,低于常规超声组的16.67%（P＜0.05）。结论：超声造影应用于甲状腺结节鉴别诊断的价值较高,且结合微波消融治疗良性结节的效果明显,预后理想,值得临床推广应用。     

孤立性肺结节患者血清CEA、NSE、Cyfra21-1水平与结节直径的关系及联合高分辨率CT的诊断价值研究

摘要 目的：研究孤立性肺结节（SPN）患者血清癌胚抗原（CEA）、神经特异性烯醇化酶（NSE）、细胞角蛋白19片段（Cyfra21-1）水平与结节直径的关系及联合高分辨率CT的诊断价值。方法：将医院从2017年3月～2020年3月期间收治的SPN患者154例纳入研究。根据术后病理检查结果分为恶性结节组104例和良性结节组50例。对所有患者均进行高分辨率CT胸部增强扫描,并比较不同结节患者的CT影像征象表现。此外,检测并比较不同结节患者的血清CEA、NSE、Cyfra21-1水平,分析血清CEA、NSE、Cyfra21-1与结节直径的关系。通过受试者工作特征（ROC）曲线分析血清CEA、NSE、Cyfra21-1水平联合高分辨率CT诊断SPN良恶性的效能。结果：肺恶性结节患者胸部CT影像征象表现为毛刺征、深分叶征、胸膜凹陷征、血管集数征、棘突征人数占比均高于良性结节,而钙化征人数占比低于良性结节（均P＜0.05）。肺恶性结节患者的血清CEA、NSE、Cyfra21-1水平均明显高于良性结节患者（均P＜0.05）。结节最大直径＞2.0 cm的SPN患者血清CEA明显高于结节最大直径1.0～2.0 cm患者,而结节最大直径1.0～2.0 cm患者血清CEA明显高于结节最大直径＜1.0c m患者（均P＜0.05）;且经Spearman相关性分析显示,血清CEA水平与SPN患者结节直径呈正相关,而血清NSE、Cyfra21-1水平与SPN患者结节直径无相关性。经ROC曲线分析可得,血清CEA、NSE、Cyfra21-1联合高分辨率CT诊断SPN良恶性的曲线下面积、灵敏度、特异度均明显高于上述各项血清学指标和高分辨率CT单独诊断。结论：SPN患者血清CEA水平与结节直径呈正相关,而血清NSE、Cyfra21-1水平与结节直径无明显相关,血清CEA、NSE、Cyfra21-1联合高分辨率CT诊断SPN良恶性的价值较高。     

甲状腺癌超声弹性成像定量参数与叉头盒A1、Yes相关蛋白的相关性研究

摘要 目的：探讨甲状腺癌患者的超声弹性成像（UE）定量参数及其与叉头盒A1（FOXA1）、Yes相关蛋白（YAP）的相关性。方法：选择2019年3月-2020年10月于本院就诊的142例甲状腺结节患者的临床资料,所有患者均为单发甲状腺结节,根据病理结果分为恶性组（72例,72个甲状腺结节）与良性组（70例,70个甲状腺结节）,所有患者行UE检查、组织活检。比较恶性组与良性组的弹性评分、应变率比值（SR）的差异,并分析恶性组的弹性评分、SR值与FOXA1、YAP的相关性。结果：恶性组的弹性评分、SR值显著高于良性组,差异有统计学意义（P<0.05）。恶性组FOXA1、YAP表达显著高于良性组,差异有统计学意义（P<0.05）。恶性组的弹性评分、SR值与FOXA1、YAP表达呈正相关（P<0.05）。结论：甲状腺结节恶性组与良性组的弹性评分、SR值及FOXA1、YAP表达的差异显著,且恶性组的弹性评分、SR值与其FOXA1、YAP表达呈正相关,UE定量参数在一定程度上可反映甲状腺癌患者的恶性的生物学行为。     

超声造影联合血清HE4、CA125、TK1、TAP对子宫内膜恶性病变的诊断价值研究

摘要 目的：探讨超声造影联合血清人附睾分泌蛋白4（HE4）、糖类抗原125（CA125）、胸苷激酶1（TK1）、肿瘤异常蛋白（TAP）对子宫内膜恶性病变的诊断价值。方法：选择2019年1月至2022年1月于济南市人民医院超声科行超声造影检查的95例子宫内膜病变患者。检测其血清HE4、CA125、TK1、TAP水平,通过超声造影检查获得造影参数开始增强时间、达峰时间、峰值强度、梯度、TIC曲线下面积（TIC-AUC）。受试者工作特征（ROC）曲线分析超声造影参数联合血清HE4、CA125、TK1、TAP诊断子宫内膜恶性病变的价值。结果：根据病理结果将患者分为恶性组（37例）和良性组（58例）,恶性组峰值强度、TIC-AUC、血清HE4、CA125、TK1、TAP水平高于良性组（P＜0.05）,恶性组开始增强时间、达峰时间、梯度与良性组比较差异无统计学意义（P＞0.05）。峰值强度、TIC-AUC、HE4、CA125、TK1、TAP 单独诊断子宫内膜恶性病变的曲线下面积为0.767、0.676、0.656、0.691、0.713、0.721,联合诊断子宫内膜恶性病变的曲线下面积为0.896,高于单独指标诊断。结论：超声造影参数峰值强度、TIC-AUC联合血清HE4、CA125、TK1、TAP诊断子宫内膜恶性病变具有较高的价值。     

经直肠剪切波弹性成像技术联合血清CEA、PSA、FPSA对前列腺良恶性病变的鉴别诊断价值研究

摘要 目的：研究经直肠剪切波弹性成像技术（TRSWE）联合血清癌胚抗原（CEA）、前列腺特异性抗原（PSA）、游离前列腺特异性抗原（FPSA）对前列腺良恶性病变的鉴别诊断价值。方法：选取合肥市第二人民医院2019年1月～2022年6月收治的90例前列腺病变患者,根据病理检查分为前列腺癌组（47例）和前列腺良性病变组（43例）。对所有前列腺病变患者均行TRSWE检查,分析前列腺良恶性病变的图像差异以及弹性模量最大值（Emax）、弹性模量平均值（Emean）。检测所有前列腺病变患者的血清CEA、PSA、FPSA水平并进行对比。采用受试者工作特征（ROC）曲线分析明确Emax值、Emean值以及血清CEA、PSA、FPSA水平联合诊断前列腺良恶性病变的效能。结果：前列腺癌组Emax值、Emean值均高于前列腺良性病变组（均P＜0.05）。前列腺癌组血清CEA、PSA及FPSA水平均高于前列腺良性病变组（均P＜0.05）。经ROC曲线分析发现,Emax值、Emean值以及血清CEA、PSA、FPSA水平联合检测诊断前列腺良恶性病变的效能优于上述5项指标单独检测。结论：TRSWE联合血清CEA、PSA、FPSA对前列腺良恶性病变的鉴别诊断价值较高,可有效提升前列腺癌的检出率,可能值得临床推广应用。     

左甲状腺素钠片联合甲状腺片用于甲状腺癌术后TSH抑制治疗的临床效果评价

摘要 目的：探究左甲状腺素钠片联合甲状腺片用于甲状腺癌术后促甲状腺激素（TSH）抑制治疗的临床效果。方法：选择2021年1月-2022年6月本院收治的甲状腺癌手术并进行碘131清甲治疗后行TSH抑制治疗的80例患者为本次研究对象,开展动态分组法,对照组及观察组,n=40。单纯左甲状腺素钠片治疗为对照组,左甲状腺素钠片联合甲状腺片治疗为观察组。比较甲状腺功能、肝肾功能、治疗效果及不良反应。结果：治疗后,游离三碘甲状腺原氨酸（FT3）、游离四碘甲状腺原氨酸（FT4）水平,观察组及对照组均较治疗前提高,但观察组低于对照组;TSH水平,两组均较治疗前降低,且观察组较对照组低（P＜0.05）;治疗前,肌酐（Scr）、谷丙转氨酶（ALT）、谷草转氨酶（AST）水平,观察组及对照组比较无差异（P＞0.05）,治疗后,各指标水平,两组均较治疗前降低,且观察组较对照组低（P＜0.05）;观察组治疗有效率高于对照组（P＜0.05）;观察组及对照组不良反应率比较无差异（P＞0.05）。结论：左甲状腺素钠片联合甲状腺片用于甲状腺癌术后TSH抑制治疗可明显改善患者甲状腺功能,提高免疫功能及治疗效果,效果优于左甲状腺素钠片单独治疗,且安全性较高。     

Simultaneous measurement of the trace elements Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum and their reference ranges by ICP-MS

The goal of this article was to establish reference ranges of the concentration of trace elements in human serum and to compare these results with those reported by other authors. We describe the sample preparation and measurement conditions that allow the rapid, precise, and accurate determination of Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum samples (n=110) by inductively coupled plasma-mass spectrometry (ICP-MS). Accuracy and precision were determined by analyzing three reconstituted reference serum samples by comparison with other methods and by the standard addition procedure. The advantages of the ICP-MS method include short time of analysis of the elements mentioned, low detection limit, high precision, and high accuracy. Disadventages include a high risk of contamination due to the presence of some of the elements of interest in the environment, the relatively delicate sample handling, and the high cost of the equipment.     

Distribution of N,P, K,Ca, Mg,S, Zn,Fe, Mn and Cu in groundnut

Summary Concentration of N, P, K, Ca, Mg and S in summer groundnut crop was higher than in kharif while Zn, Fe, Mn and Cu contents were higher in summer crop. Kernel's N, P and Zn; Leaflet's Ca and Mn; Stem's K and Fe; Root's S and Cu and Petiole's Mg contents were highest. Shell's N, P, K, Mg, S, Zn and Cu; Kernel's Ca, Fe and Mn contents were the least. N, P, K, S, Zn and Cu concentrations decreased linearly as the crop grew. Ca, Mg, Fe and Mn concentrations did not display any distinct pattern. Ca concentration was positively correlated with pod yield in both the seasons.     

Reference values for the concentrations of As,Cd, Co,Cr, Cu,Fe, I,Hg, Mn,Mo, Ni,Pb, Se,and Zn in selected human tissues and body fluids

This report attempts to formulate reference ranges of elemental concentrations for 15 trace elements in selected human tissues and body fluids. A set of samples consisting of whole blood, blood serum, urine, milk, liver, and hair were chosen and considered for 15 elements of biological significance: As, Cd, Co, Cr, Cu, F, Fe, I, Hg, Mn, Mo, Ni, Pb, Se, and Zn. The results represent wholly or partially data received from 40 countries of the global regions of Africa, Asia, Europe, North, South, and Central America, Australia, and New Zealand. This survey, even if qualitative, has been useful in demonstrating certain trends of trace-element scenarios around the world. It is of course recognized that both diet and environment exert a strong influence on the distribution pattern of several elements, such as As, Cd, Mn, Pb, Se, and Zn. A limited comparison of the available information on soil status of different countries reflected some interesting associations for elements, such as Mn and Zn. Importantly, this study revealed that only a few countries were in a position to identify a reasonable amount of data on samples requested for this project. Regretably, for a number of countries, any dependable data for even such essential elements as Cu, Fe, and Zn were not available. In view of the nutritional importance of many elements, the time is ripe for concerted efforts by intergovernmental agencies to initiate investigations or commission task forces/projects to generate reliable reference data for selected global regions, which sadly lack data of any kind at present.     

Crystal structure, detonation performance, and thermal stability of a new polynitro cage compound: 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptacyclo [5.5.1.13, 11. 15, 9] pentadecane

A new polynitro cage compound 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptcyclo [5.5.1.1(3,11).1(5,9)] pentadecane (NNNAHP) was designed in the present work. Its molecular structure was optimized at the B3LYP/6-31 G(d,p) level of density functional theory (DFT) and crystal structure was predicted using the Compass and Dreiding force fields and refined by DFT GGA-RPBE method. The obtained crystal structure of NNNAHP belongs to the P-1 space group and the lattice parameters are a = 9.99 ?, b = 10.78 ?, c = 9.99 ?, α = 90.01°, β = 120.01°, γ = 90.00°, and Z = 2, respectively. Based on the optimized crystal structure, the band gap, density of state, thermodynamic properties, infrared spectrum, strain energy, detonation characteristics, and thermal stability were predicted. Calculation results show that NNNAHP has detonation properties close to those of CL-20 and is a high energy density compound with moderate stability.     

Monovalent Cation Permeation through the Connexin40 Gap Junction Channel : Cs,Rb, K,Na, Li,TEA, TMA,TBA, and Effects of Anions Br,Cl, F,Acetate, Aspartate,Glutamate, and NO3

The unitary conductances and permeability sequences of the rat connexin40 (rCx40) gap junction channels to seven monovalent cations and anions were studied in rCx40-transfected neuroblastoma 2A (N2A) cell pairs using the dual whole cell recording technique. Chloride salt cation substitutions (115 mM principal salt) resulted in the following junctional maximal single channel current-voltage relationship slope conductances (γ_j in pS): CsCl (153), RbCl (148), KCl (142), NaCl (115), LiCl (86), TMACl (71), TEACl (63). Reversible block of the rCx40 channel was observed with TBA. Potassium anion salt γ_j are: Kglutamate (160), Kacetate (160), Kaspartate (158), KNO₃ (157), KF (148), KCl (142), and KBr (132). Ion selectivity was verified by measuring reversal potentials for current in rCx40 gap junction channels with asymmetric salt solutions in the two electrodes and using the Goldman-Hodgkin-Katz equation to calculate relative permeabilities. The permeabilities relative to Li⁺ are: Cs⁺ (1.38), Rb⁺ (1.32), K⁺ (1.31), Na⁺ (1.16), TMA⁺ (0.53), TEA⁺ (0.45), TBA⁺ (0.03), Cl⁻ (0.19), glutamate⁻ (0.04), and NO₃− (0.14), assuming that the monovalent anions permeate the channel by forming ion pairs with permeant monovalent cations within the pore thereby causing proportionate decreases in the channel conductance. This hypothesis can account for why the predicted increasing conductances with increasing ion mobilities in an essentially aqueous channel were not observed for anions in the rCx40 channel. The rCx40 effective channel radius is estimated to be 6.6 Å from a theoretical fit of the relationship of relative permeability and cation radius.     

Relations of the Al,B, Ba,Br, Ca,Cl, Cu,Fe, K,Li, Mg,Mn, Na,P, S,Si, Sr,and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands

The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0–30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.0, B 0.40 ± 0.11, Ba 1.48 ± 0.44, Br 10.5 ± 1.5, Ca 241 ± 30, Cl 3,203 ± 278, Cu 3.51 ± 0.89, Fe 33.7 ± 4.1, K 2,364 ± 145, Li 0.020 ± 0.004, Mg 153 ± 23, Mn 0.46 ± 0.06, Na 2,286 ± 130, P 1,391 ± 100, S 1,698 ± 132, Si 62 ± 11, Sr 0.38 ± 0.08, and Zn 27.6 ± 2.3. During puberty and postpuberty, when there is a significant increase in circulating androgens, the mean values were: Al 7.2 ± 1.4, B 0.21 ± 0.05, Ba 0.25 ± 0.06, Br 5.8 ± 1.0, Ca 433 ± 81, Cl 2,314 ± 201, Cu 1.77 ± 0.13, Fe 20.9 ± 1.6, K 2,585 ± 118, Li 0.0088 ± 0.0014, Mg 232 ± 27, Mn 0.34 ± 0.04, Na 1,875 ± 107, P 1,403 ± 98, S 1,673 ± 73, Si 22.2 ± 3.1, Sr 0.22 ± 0.03, and Zn 93.3 ± 8.9. Mean values (M ± SΕΜ) of percent volumes (%) of the stroma, epithelium and lumen in the prostate before puberty were 73.4 ± 2.6, 20.4 ± 1.7, and 4.45 ± 0.94, respectively, versus 46.5 ± 2.5, 38.5 ± 1.9, and 14.9 ± 1.2 during puberty and postpuberty. This work’s results confirm that the Zn mass fraction in prostate tissue is an androgen-dependent parameter. For the first time it has been demonstrated that the glandular lumen is a main pool of Ca, Mg, and Zn accumulation and that the stroma is a main pool of Al, B, Ba, Br, Cl, Cu, Fe, Mn, Na, and Si accumulation in the normal human prostate, for the age range 0–30 years. It was concluded that the Ca, Mg, and Zn binds tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid.     

The Effect of Age and Gender on Al, B, Ba, Ca, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Sr, V, and Zn Contents in Rib Bone of Healthy Humans

The effect of age and gender on major, minor, and trace element contents in the intact rib bone of 80 relatively healthy 15–55-year-old women and men was investigated. Contents or upper limit of contents of 16 chemical elements in the rib bone were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Mean values (M?±?SΕΜ) for the mass fraction of Ba, Ca, Cu, Fe, K, Li, Mg, Na, P, S, Sr, and Zn (milligram per kilogram of dry bone) were as follows: 2.54?±?0.16, 171,400?±?4,050, 1.35?±?0.22, 140?±?11, 1,874?±?71, 0.049?±?0.011, 2,139?±?38, 5,378?±?88, 75,140?±?1,660, 1,881?±?51, 291?±?20, and 92.8?±?1.5, respectively. The upper limits of contents of Al, B, Mn, and V were <7.20, <0.65, <0.36, and <0.03, respectively. Statistically significant tendency for the Ca, Mg, and P content to decrease with age was found in the human rib bone, regardless of gender. The mass fraction of Fe in the male rib bone increases with age. It was shown that higher Ca, Mg, Na, P, and Sr mass fractions as well as lower Fe content were typical of female ribs as compared to those in male ribs.     

Potential Compounds for Oral Cancer Treatment: Resveratrol,Nimbolide, Lovastatin,Bortezomib, Vorinostat,Berberine, Pterostilbene,Deguelin, Andrographolide,and Colchicine

Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer. Research endeavors focused on discovery and development of novel therapies for oral cancer, is necessary to control the ever rising oral cancer related mortalities. We mined the large pool of compounds from the publicly available compound databases, to identify potential therapeutic compounds for oral cancer. Over 84 million compounds were screened for the possible anti-cancer activity by custom build SVM classifier. The molecular targets of the predicted anti-cancer compounds were mined from reliable sources like experimental bioassays studies associated with the compound, and from protein-compound interaction databases. Therapeutic compounds from DrugBank, and a list of natural anti-cancer compounds derived from literature mining of published studies, were used for building partial least squares regression model. The regression model thus built, was used for the estimation of oral cancer specific weights based on the molecular targets. These weights were used to compute scores for screening the predicted anti-cancer compounds for their potential to treat oral cancer. The list of potential compounds was annotated with corresponding physicochemical properties, cancer specific bioactivity evidences, and literature evidences. In all, 288 compounds with the potential to treat oral cancer were identified in the current study. The majority of the compounds in this list are natural products, which are well-tolerated and have minimal side-effects compared to the synthetic counterparts. Some of the potential therapeutic compounds identified in the current study are resveratrol, nimbolide, lovastatin, bortezomib, vorinostat, berberine, pterostilbene, deguelin, andrographolide, and colchicine.