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Ziv Radisavljevic 《Journal of cellular biochemistry》2018,119(1):130-133
Generation and maintenance of a cancer complexity and robustness are impossible without hydrogen element. It is essential element for the cancer signaling through the AKT locus. Hyperactivated AKT locus by a positive feedback loops from the cancer hypoxic microenvironment generates a hydrogen bond network. Such network initiates protein–protein interaction at the AKT active site and at the same time stabilizes signal propagation. A hydrogen bond network conforms an entropy/enthalpy energetic process used for the interconversion of the AKT protein in metastasis formation and maintenance. Targeting the AKT locus by the redox balance change or hydrogen balance change or proton beam radiation disrupts a hydrogen bond network leading to the disappearance of a cancer complexity and robustness causing failure of the complex energy system in solid cancers and hematological malignancy. J. Cell. Biochem. 119: 130–133, 2018. © 2017 Wiley Periodicals, Inc. 相似文献
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PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells,Involving Autophagy 下载免费PDF全文
Damián E. Berardi Carolina Flumian Cristina E. Rodriguez María I. Díaz Bessone Stefano M. Cirigliano Elisa D. Bal de Kier Joffé Gabriel L. Fiszman Alejandro J. Urtreger Laura B. Todaro 《Journal of cellular biochemistry》2016,117(3):730-740
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Up‐Regulation of MicroRNA‐133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio‐Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro 下载免费PDF全文
Qing‐Shan Yang Li‐Peng Jiang Chun‐Yan He Yu‐Na Tong Yuan‐Yuan Liu 《Journal of cellular biochemistry》2017,118(9):2625-2634
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Breast Cancer Stem Cell Therapeutics,Multiple Strategies Versus Using Engineered Mesenchymal Stem Cells With Notch Inhibitory Properties: Possibilities and Perspectives 下载免费PDF全文
Relapse cases of cancers are more vigorous and difficult to control due to the preponderance of cancer stem cells (CSCs). Such CSCs that had been otherwise dormant during the first incidence of cancer gradually appear as radiochemoresistant cancer cells. Hence, cancer therapeutics aimed at CSCs would be an effective strategy for mitigating the cancers during relapse. Alternatively, CSC therapy can also be proposed as an adjuvant therapy, along‐with the conventional therapies. As regenerative stem cells (RSCs) are known for their trophic effects, anti‐tumorogenicity, and better migration toward an injury site, this review aims to address the use of adult stem cells such as dental pulp derived; cord blood derived pure populations of regenerative stem cells for targeting CSCs. Indeed, pro‐tumorogenicity of RSCs is of concern and hence has also been dealt with in relation to breast CSC therapeutics. Furthermore, as notch signaling pathways are upregulated in breast cancers, and anti‐notch antibody based and sh‐RNA based therapies are already in the market, this review focuses the possibilities of engineering RSCs to express notch inhibitory proteins for breast CSC therapeutics. Also, we have drawn a comparison among various possibilities of breast CSC therapeutics, about, notch1 inhibition. J. Cell. Biochem. 119: 141–149, 2018. © 2017 Wiley Periodicals, Inc. 相似文献
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