共查询到10条相似文献,搜索用时 78 毫秒
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Genotype, malleotype, phenotype, and randomness: lessons from neurofibromatosis-1 (NF-1) 总被引:5,自引:0,他引:5 下载免费PDF全文
V M Riccardi 《American journal of human genetics》1993,53(2):301-304
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Solution conformation of asparagine-linked oligosaccharides: alpha(1-2)-, alpha(1-3)-, beta(1-2)-, and beta(1-4)-linked units 总被引:1,自引:0,他引:1
The solution conformation is presented for representatives of each of the major classes of asparaginyl oligosaccharides. In this report the conformation of alpha(1-3)-, alpha(1-2)-, beta(1-2)-, and beta(1-4)-linked units is described. The conformational properties of these glycopeptides were determined by high-resolution 1H nuclear magnetic resonance in conjunction with potential energy calculations. The NMR parameters that were used in this analysis were chemical shifts and nuclear Overhauser enhancements. Potential energy calculations were used to evaluate the preferred conformers available for the different linkages in glycopeptides and to draw conclusions about the behavior in solution of these molecules. It was found that the linkage conformation of the Man alpha 1-3 residues was not affected by substitution either at the 2-position by alpha Man or beta GlcNAc or at the 4-position by beta GlcNAc or by the presence of a bisecting GlcNAc on the adjacent beta Man residue. 相似文献
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Espinoza A Le Blanc S Olivares M Pizarro F Ruz M Arredondo M 《Biological trace element research》2012,146(2):281-286
Iron (Fe), copper (Cu), and zinc (Zn) fulfill various essential biological functions and are vital for all living organisms.
They play important roles in oxygen transport, cell growth and differentiation, neurotransmitter synthesis, myelination, and
synaptic transmission. Because of their role in many critical functions, they are commonly used in food fortification and
supplementation strategies globally. To determine the involvement of divalent metal transporter 1 (DMT1) and human copper
transporter 1 (hCTR1) on Fe, Cu, and Zn uptake, Caco-2 cells were transfected with four different shRNA plasmids to selectively
inhibit DMT1 or hCTR1 transporter expression. Fe and Cu uptake and total Zn content measurements were performed in shRNA-DMT1
and shRNA-hCTR1 cells. Both shRNA-DMT1 and shRNA-hCTR1 cells had lower apical Fe uptake (a decrease of 51% and 41%, respectively),
Cu uptake (a decrease of 25.8% and 38.5%, respectively), and Zn content (a decrease of 23.1% and 22.7%, respectively) compared
to control cells. These results confirm that DMT1 is involved in active transport of Fe, Cu, and Zn although Zn showed a different
relative capacity. These results also show that hCTR1 is able to transport Fe and Zn. 相似文献