共查询到20条相似文献,搜索用时 15 毫秒
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Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter 总被引:18,自引:0,他引:18 下载免费PDF全文
Yoshikawa T Shimano H Amemiya-Kudo M Yahagi N Hasty AH Matsuzaka T Okazaki H Tamura Y Iizuka Y Ohashi K Osuga J Harada K Gotoda T Kimura S Ishibashi S Yamada N 《Molecular and cellular biology》2001,21(9):2991-3000
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Ishimoto K Tachibana K Sumitomo M Omote S Hanano I Yamasaki D Watanabe Y Tanaka T Hamakubo T Sakai J Kodama T Doi T 《FEBS letters》2006,580(20):4929-4933
Liver X receptor alpha (LXRalpha) is a member of the nuclear receptor superfamily that is activated by oxysterols, and plays a pivotal role in regulating the metabolism, transport and uptake of cholesterol. Here, we demonstrate that LXRalpha also regulates the low-density lipoprotein receptor (LDLR) gene, which mediates the endocytic uptake of LDL cholesterol in the liver. An LXR agonist induced the expression of LDLR in cultured hepatoblastoma cells. Moreover, the LDLR promoter contained an LXR response element that was recognized by LXRalpha/RXRalpha (retinoid X receptor alpha) heterodimers in hepatoblastoma cells. These results suggest a novel pathway whereby LXRalpha might modulate cholesterol metabolism. 相似文献
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Mick VE Itani OA Loftus RW Husted RF Schmidt TJ Thomas CP 《Molecular endocrinology (Baltimore, Md.)》2001,15(4):575-588
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M Matsumoto K Hisatake Y Nogi M Tsujimoto 《The Journal of biological chemistry》2001,276(35):33086-33092
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