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Alpha/beta interferon differentially modulates the clearance of cytoplasmic encapsidated replication intermediates and nuclear covalently closed circular hepatitis B virus (HBV) DNA from the livers of hepatocyte nuclear factor 1alpha-null HBV transgenic mice 总被引:1,自引:0,他引:1 下载免费PDF全文
Treatment with alpha interferon is a standard therapy for patients with chronic hepatitis B virus (HBV) infections. This treatment can reduce virus load and ameliorate disease symptoms. However, in the majority of cases, alpha interferon therapy fails to resolve the chronic HBV infection. The reason alpha interferon therapy is inefficient at resolving chronic HBV infections is assumed to be because it fails to eliminate covalently closed circular (CCC) HBV DNA from the nuclei of infected hepatocytes. In an attempt to address this issue, the stability of HBV CCC DNA in response to alpha/beta interferon induction was examined in HNF1alpha-null HBV transgenic mice. Alpha/beta interferon induction by polyinosinic-polycytidylic acid [poly(I-C)] treatment efficiently eliminated encapsidated cytoplasmic HBV replication intermediates while only modestly reducing nuclear HBV CCC DNA. These observations indicate that nuclear HBV CCC DNA is more stable than cytoplasmic replication intermediates in response to alpha/beta interferon induction. Consequently it appears that for therapies to resolve chronic HBV infection efficiently, they will have to target the elimination of the most stable HBV replication intermediate, nuclear HBV CCC DNA. 相似文献
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Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo 总被引:3,自引:0,他引:3 下载免费PDF全文
Banks KE Anderson AL Tang H Hughes DE Costa RH McLachlan A 《Journal of virology》2002,76(24):12974-12980
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In vivo regulation of hepatitis B virus replication by peroxisome proliferators 总被引:2,自引:0,他引:2 下载免费PDF全文
Guidotti LG Eggers CM Raney AK Chi SY Peters JM Gonzalez FJ McLachlan A 《Journal of virology》1999,73(12):10377-10386
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Novel type of hepatitis B virus mutation: replacement mutation involving a hepatocyte nuclear factor 1 binding site tandem repeat in chronic hepatitis B virus genotype E 下载免费PDF全文
Fujiwara K Tanaka Y Paulon E Orito E Sugiyama M Ito K Ueda R Mizokami M Naoumov NV 《Journal of virology》2005,79(22):14404-14410